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Articles published in Development

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    January 2012
  1. SETTY Y , Dalfo D, Korta DZ, Hubbard EJ, et al
    A model of stem cell population dynamics: in silico analysis and in vivo validation.
    Development. 2012;139:47-56.
    PubMed     Text format     Related articles    Abstract available



  2. POURQUIE O
    A niche for stem cell research.
    Development. 2012;139:1-2.
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  3. BLUM N , Begemann G
    Retinoic acid signaling controls the formation, proliferation and survival of the blastema during adult zebrafish fin regeneration.
    Development. 2012;139:107-16.
    PubMed     Text format     Related articles    Abstract available



  4. AHNFELT-RONNE J , Jorgensen MC, Klinck R, Jensen JN, et al
    Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism.
    Development. 2012;139:33-45.
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  5. WILSCH-BRAUNINGER M , Peters J, Paridaen JT, Huttner WB, et al
    Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination.
    Development. 2012;139:95-105.
    PubMed     Text format     Related articles    Abstract available



    December 2011
  6. VANDUSSEN KL , Carulli AJ, Keeley TM, Patel SR, et al
    Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  7. LAKOMA J , Garcia-Alonso L, Luque JM
    Reelin sets the pace of neocortical neurogenesis.
    Development. 2011;138:5223-34.
    PubMed     Text format     Related articles    Abstract available



  8. ASAMI M , Pilz GA, Ninkovic J, Godinho L, et al
    The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex.
    Development. 2011;138:5067-78.
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  9. ISHITOBI H , Wakamatsu A, Liu F, Azami T, et al
    Molecular basis for Flk1 expression in hemato-cardiovascular progenitors in the mouse.
    Development. 2011;138:5357-68.
    PubMed     Text format     Related articles    Abstract available



  10. STARK DA , Karvas RM, Siegel AL, Cornelison DD, et al
    Eph/ephrin interactions modulate muscle satellite cell motility and patterning.
    Development. 2011;138:5279-89.
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  11. KARUS M , Denecke B, ffrench-Constant C, Wiese S, et al
    The extracellular matrix molecule tenascin C modulates expression levels and territories of key patterning genes during spinal cord astrocyte specification.
    Development. 2011;138:5321-31.
    PubMed     Text format     Related articles    Abstract available



    November 2011
  12. MARDARYEV AN , Meier N, Poterlowicz K, Sharov AA, et al
    Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury.
    Development. 2011;138:4843-52.
    PubMed     Text format     Related articles    Abstract available



  13. HAN J , Lee JE, Jin J, Lim JS, et al
    The spatiotemporal development of adipose tissue.
    Development. 2011;138:5027-37.
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  14. DI LULLO E , Haton C, Le Poupon C, Volovitch M, et al
    Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube.
    Development. 2011;138:4991-5001.
    PubMed     Text format     Related articles    Abstract available



  15. THEUNISSEN TW , Costa Y, Radzisheuskaya A, van Oosten AL, et al
    Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.
    Development. 2011;138:4853-65.
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  16. KROEHNE V , Freudenreich D, Hans S, Kaslin J, et al
    Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors.
    Development. 2011;138:4831-41.
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  17. RASMUSSEN TL , Kweon J, Diekmann MA, Belema-Bedada F, et al
    ER71 directs mesodermal fate decisions during embryogenesis.
    Development. 2011;138:4801-12.
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  18. LEI J , Howard MJ
    Targeted deletion of Hand2 in enteric neural precursor cells affects its functions in neurogenesis, neurotransmitter specification and gangliogenesis, causing functional aganglionosis.
    Development. 2011;138:4789-800.
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  19. MILGROM-HOFFMAN M , Harrelson Z, Ferrara N, Zelzer E, et al
    The heart endocardium is derived from vascular endothelial progenitors.
    Development. 2011;138:4777-87.
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  20. PALENCIA-DESAI S , Kohli V, Kang J, Chi NC, et al
    Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function.
    Development. 2011;138:4721-32.
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  21. FUKADA S , Yamaguchi M, Kokubo H, Ogawa R, et al
    Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
    Development. 2011;138:4609-19.
    PubMed     Text format     Related articles    Abstract available



  22. DALGIN G , Ward AB, Hao le T, Beattie CE, et al
    Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas.
    Development. 2011;138:4597-608.
    PubMed     Text format     Related articles    Abstract available



  23. KELLER G
    An interview with Gordon Keller. Interview by Eva Amsen.
    Development. 2011;138:4567.
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  24. JOHNSON AN , Mokalled MH, Haden TN, Olson EN, et al
    JAK/Stat signaling regulates heart precursor diversification in Drosophila.
    Development. 2011;138:4627-38.
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    October 2011
  25. INABA M , Yuan H, Yamashita YM
    String (Cdc25) regulates stem cell maintenance, proliferation and aging in Drosophila testis.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  26. KIRILLY D , Wang S, Xie T
    Self-maintained escort cells form a germline stem cell differentiation niche.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  27. WILDWATER M , Sander N, de Vreede G, van den Heuvel S, et al
    Cell shape and Wnt signaling redundantly control the division axis of C. elegans epithelial stem cells.
    Development. 2011;138:4375-85.
    PubMed     Text format     Related articles    Abstract available



  28. SCIMONE ML , Srivastava M, Bell GW, Reddien PW, et al
    A regulatory program for excretory system regeneration in planarians.
    Development. 2011;138:4387-98.
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  29. CASSANO M , Dellavalle A, Tedesco FS, Quattrocelli M, et al
    Alpha sarcoglycan is required for FGF-dependent myogenic progenitor cell proliferation in vitro and in vivo.
    Development. 2011;138:4523-33.
    PubMed     Text format     Related articles    Abstract available



  30. LOEBEL DA , Studdert JB, Power M, Radziewic T, et al
    Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm.
    Development. 2011;138:4511-22.
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  31. YANG CP , Gilley JA, Zhang G, Kernie SG, et al
    ApoE is required for maintenance of the dentate gyrus neural progenitor pool.
    Development. 2011;138:4351-62.
    PubMed     Text format     Related articles    Abstract available



    September 2011
  32. PERDIGOTO CN , Schweisguth F, Bardin AJ
    Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  33. SOKOL SY
    Maintaining embryonic stem cell pluripotency with Wnt signaling.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  34. JULIO MK , Alvarez MJ, Galli A, Chu J, et al
    Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling.
    Development. 2011;138:3885-95.
    PubMed     Text format     Related articles    Abstract available



  35. HAYASHI T , Motoishi M, Yazawa S, Itomi K, et al
    A LIM-homeobox gene is required for differentiation of Wnt-expressing cells at the posterior end of the planarian body.
    Development. 2011;138:3679-88.
    PubMed     Text format     Related articles    Abstract available



  36. MCCARTHY JJ , Mula J, Miyazaki M, Erfani R, et al
    Effective fiber hypertrophy in satellite cell-depleted skeletal muscle.
    Development. 2011;138:3657-66.
    PubMed     Text format     Related articles    Abstract available



  37. SAMBASIVAN R , Yao R, Kissenpfennig A, Van Wittenberghe L, et al
    Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration.
    Development. 2011;138:3647-56.
    PubMed     Text format     Related articles    Abstract available



  38. LEPPER C , Partridge TA, Fan CM
    An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration.
    Development. 2011;138:3639-46.
    PubMed     Text format     Related articles    Abstract available



  39. MURPHY MM , Lawson JA, Mathew SJ, Hutcheson DA, et al
    Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration.
    Development. 2011;138:3625-37.
    PubMed     Text format     Related articles    Abstract available



  40. WANG H , Lei Q, Oosterveen T, Ericson J, et al
    Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS.
    Development. 2011;138:3711-21.
    PubMed     Text format     Related articles    Abstract available



  41. MCGRAW HF , Drerup CM, Culbertson MD, Linbo T, et al
    Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.
    Development. 2011;138:3921-30.
    PubMed     Text format     Related articles    Abstract available



  42. FALENTA K , Rodaway A
    Definitive erythropoiesis in the trunk of zebrafish embryos.
    Development. 2011;138:3861-2.
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  43. TOKUSUMI T , Tokusumi Y, Hopkins DW, Shoue DA, et al
    Germ line differentiation factor Bag of Marbles is a regulator of hematopoietic progenitor maintenance during Drosophila hematopoiesis.
    Development. 2011;138:3879-84.
    PubMed     Text format     Related articles    Abstract available



    August 2011
  44. JAEGER I , Arber C, Risner-Janiczek JR, Kuechler J, et al
    Temporally controlled modulation of FGF/ERK signaling directs midbrain dopaminergic neural progenitor fate in mouse and human pluripotent stem cells.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  45. GOKOFFSKI KK , Wu HH, Beites CL, Kim J, et al
    Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate.
    Development. 2011.
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  46. FLICI H , Erkosar B, Komonyi O, Karatas OF, et al
    Gcm/Glide-dependent conversion into glia depends on neural stem cell age, but not on division, triggering a chromatin signature that is conserved in vertebrate glia.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  47. BOYLE SC , Kim M, Valerius MT, McMahon AP, et al
    Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  48. DELAFOREST A , Nagaoka M, Si-Tayeb K, Noto FK, et al
    HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  49. KLEIN AM , Simons BD
    Universal patterns of stem cell fate in cycling adult tissues.
    Development. 2011;138:3103-11.
    PubMed     Text format     Related articles    Abstract available



  50. RUSSELL RC , Fang C, Guan KL
    An emerging role for TOR signaling in mammalian tissue and stem cell physiology.
    Development. 2011;138:3343-56.
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  51. SIMOES FC , Peterkin T, Patient R
    Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators.
    Development. 2011;138:3235-45.
    PubMed     Text format     Related articles    Abstract available



  52. ANDERSON KR , Singer RA, Balderes DA, Hernandez-Lagunas L, et al
    The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration.
    Development. 2011;138:3213-24.
    PubMed     Text format     Related articles    Abstract available



  53. SKAGGS K , Martin DM, Novitch BG
    Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling.
    Development. 2011;138:3199-211.
    PubMed     Text format     Related articles    Abstract available



  54. AMSEN E
    An interview with Magdalena Gotz.
    Development. 2011;138:3341-2.
    PubMed     Text format     Related articles   



  55. BRZEZINSKI JA 4TH , Kim EJ, Johnson JE, Reh TA, et al
    Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina.
    Development. 2011;138:3519-31.
    PubMed     Text format     Related articles    Abstract available



    July 2011
  56. GOLDING MC , Magri LS, Zhang L, Lalone SA, et al
    Depletion of Kcnq1ot1 non-coding RNA does not affect imprinting maintenance in stem cells.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  57. CASPER AL , Baxter K, Van Doren M
    no child left behind encodes a novel chromatin factor required for germline stem cell maintenance in males but not females.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  58. SHENG XR , Matunis E
    Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  59. DE CUEVAS M , Matunis EL
    The stem cell niche: lessons from the Drosophila testis.
    Development. 2011;138:2861-9.
    PubMed     Text format     Related articles    Abstract available



  60. HALPERIN-BARLEV O , Kalcheim C
    Sclerotome-derived Slit1 drives directional migration and differentiation of Robo2-expressing pioneer myoblasts.
    Development. 2011;138:2935-45.
    PubMed     Text format     Related articles    Abstract available



    June 2011
  61. MORRIS LX , Spradling AC
    Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary.
    Development. 2011;138:2207-15.
    PubMed     Text format     Related articles    Abstract available



  62. CHEN X , Lu C, Prado JR, Eun SH, et al
    Sequential changes at differentiation gene promoters as they become active in a stem cell lineage.
    Development. 2011;138:2441-50.
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  63. MILLANE RC , Kanska J, Duffy DJ, Seoighe C, et al
    Induced stem cell neoplasia in a cnidarian by ectopic expression of a POU domain transcription factor.
    Development. 2011;138:2429-39.
    PubMed     Text format     Related articles    Abstract available



  64. MUKHERJEE P , Gildor B, Shilo BZ, VijayRaghavan K, et al
    The actin nucleator WASp is required for myoblast fusion during adult Drosophila myogenesis.
    Development. 2011;138:2347-57.
    PubMed     Text format     Related articles    Abstract available



  65. FOX PM , Vought VE, Hanazawa M, Lee MH, et al
    Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline.
    Development. 2011;138:2223-34.
    PubMed     Text format     Related articles    Abstract available



  66. TAN Y , Yamada-Mabuchi M, Arya R, St Pierre S, et al
    Coordinated expression of cell death genes regulates neuroblast apoptosis.
    Development. 2011;138:2197-206.
    PubMed     Text format     Related articles    Abstract available



  67. OUYANG Y , Petritsch C, Wen H, Jan L, et al
    Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila.
    Development. 2011;138:2185-96.
    PubMed     Text format     Related articles    Abstract available



  68. PEARSON CA , Ohyama K, Manning L, Aghamohammadzadeh S, et al
    FGF-dependent midline-derived progenitor cells in hypothalamic infundibular development.
    Development. 2011;138:2613-24.
    PubMed     Text format     Related articles    Abstract available



  69. HAMMERLE B , Ulin E, Guimera J, Becker W, et al
    Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling.
    Development. 2011;138:2543-54.
    PubMed     Text format     Related articles    Abstract available



  70. TASAKI J , Shibata N, Nishimura O, Itomi K, et al
    ERK signaling controls blastema cell differentiation during planarian regeneration.
    Development. 2011;138:2417-27.
    PubMed     Text format     Related articles    Abstract available



  71. WU S , Esumi S, Watanabe K, Chen J, et al
    Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon.
    Development. 2011;138:2499-509.
    PubMed     Text format     Related articles    Abstract available



    May 2011
  72. CHIANG PM , Wong PC
    Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: essential role of bone morphogenetic protein 4.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  73. DINARDO S , Okegbe T, Wingert L, Freilich S, et al
    lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis.
    Development. 2011;138:1687-96.
    PubMed     Text format     Related articles    Abstract available



  74. VAN HATEREN NJ , Das RM, Hautbergue GM, Borycki AG, et al
    FatJ acts via the Hippo mediator Yap1 to restrict the size of neural progenitor cell pools.
    Development. 2011;138:1893-902.
    PubMed     Text format     Related articles    Abstract available



  75. KATSUMOTO K , Kume S
    Endoderm and mesoderm reciprocal signaling mediated by CXCL12 and CXCR4 regulates the migration of angioblasts and establishes the pancreatic fate.
    Development. 2011;138:1947-55.
    PubMed     Text format     Related articles    Abstract available



  76. KIM SY , Rane SG
    The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.
    Development. 2011;138:1903-12.
    PubMed     Text format     Related articles    Abstract available



  77. KOHWI M , Hiebert LS, Doe CQ
    The pipsqueak-domain proteins Distal antenna and Distal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity.
    Development. 2011;138:1727-35.
    PubMed     Text format     Related articles    Abstract available



    April 2011
  78. GUNTUR AR , Reinhold MI, Cuellar J Jr, Naski MC, et al
    Conditional ablation of Pten in osteoprogenitors stimulates FGF signaling.
    Development. 2011;138:1433-44.
    PubMed     Text format     Related articles    Abstract available



  79. KARNER CM , Das A, Ma Z, Self M, et al
    Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development.
    Development. 2011;138:1247-57.
    PubMed     Text format     Related articles    Abstract available



  80. TIAN Y , Zhang Y, Hurd L, Hannenhalli S, et al
    Regulation of lung endoderm progenitor cell behavior by miR302/367.
    Development. 2011;138:1235-45.
    PubMed     Text format     Related articles    Abstract available



  81. OKEGBE TC , DiNardo S
    The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling.
    Development. 2011;138:1259-67.
    PubMed     Text format     Related articles    Abstract available



  82. HARALALKA S , Shelton C, Cartwright HN, Katzfey E, et al
    Asymmetric Mbc, active Rac1 and F-actin foci in the fusion-competent myoblasts during myoblast fusion in Drosophila.
    Development. 2011;138:1551-62.
    PubMed     Text format     Related articles    Abstract available



    March 2011
  83. CASANOVA M , Preissner T, Cerase A, Poot R, et al
    Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  84. ROTHENAIGNER I , Krecsmarik M, Hayes JA, Bahn B, et al
    Clonal analysis by distinct viral vectors identifies bona fide neural stem cells in the adult zebrafish telencephalon and characterizes their division properties and fate.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  85. CHENG J , Tiyaboonchai A, Yamashita YM, Hunt AJ, et al
    Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning.
    Development. 2011;138:831-7.
    PubMed     Text format     Related articles    Abstract available



  86. COSTA MR , Ortega F, Brill MS, Beckervordersandforth R, et al
    Continuous live imaging of adult neural stem cell division and lineage progression in vitro.
    Development. 2011;138:1057-68.
    PubMed     Text format     Related articles    Abstract available



  87. GONZALEZ-GARCIA MP , Vilarrasa-Blasi J, Zhiponova M, Divol F, et al
    Brassinosteroids control meristem size by promoting cell cycle progression in Arabidopsis roots.
    Development. 2011;138:849-59.
    PubMed     Text format     Related articles    Abstract available



  88. DAUGHTERS RS , Chen Y, Slack JM
    Origin of muscle satellite cells in the Xenopus embryo.
    Development. 2011;138:821-30.
    PubMed     Text format     Related articles    Abstract available



  89. MEDVINSKY A , Rybtsov S, Taoudi S
    Embryonic origin of the adult hematopoietic system: advances and questions.
    Development. 2011;138:1017-31.
    PubMed     Text format     Related articles   



    February 2011
  90. BITEAU B , Jasper H
    EGF signaling regulates the proliferation of intestinal stem cells in Drosophila.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  91. MATSUSHIMA D , Heavner W, Pevny LH
    Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6.
    Development. 2011;138:443-54.
    PubMed     Text format     Related articles    Abstract available



  92. KOPINKE D , Brailsford M, Shea JE, Leavitt R, et al
    Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas.
    Development. 2011;138:431-41.
    PubMed     Text format     Related articles    Abstract available



  93. ZHONG J , Kim HT, Lyu J, Yoshikawa K, et al
    The Wnt receptor Ryk controls specification of GABAergic neurons versus oligodendrocytes during telencephalon development.
    Development. 2011;138:409-19.
    PubMed     Text format     Related articles    Abstract available



  94. KOPP JL , Dubois CL, Schaffer AE, Hao E, et al
    Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas.
    Development. 2011;138:653-65.
    PubMed     Text format     Related articles    Abstract available



  95. OATES AC
    What's all the noise about developmental stochasticity?
    Development. 2011;138:601-7.
    PubMed     Text format     Related articles    Abstract available



  96. DU L , Xu J, Li X, Ma N, et al
    Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis.
    Development. 2011;138:619-29.
    PubMed     Text format     Related articles    Abstract available



    January 2011
  97. NOSTRO MC , Sarangi F, Ogawa S, Holtzinger A, et al
    Stage-specific signaling through TGF{beta} family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  98. MUNDELL NA , Labosky PA
    Neural crest stem cell multipotency requires Foxd3 to maintain neural potential and repress mesenchymal fates.
    Development. 2011.
    PubMed     Text format     Related articles    Abstract available



  99. YAJIMA M , Wessel GM
    Small micromeres contribute to the germline in the sea urchin.
    Development. 2011;138:237-43.
    PubMed     Text format     Related articles    Abstract available



  100. SCHERES B
    An interview with Ben Scheres by Kathryn Senior.
    Development. 2011;138:181-2.
    PubMed     Text format     Related articles   



  101. GOMES FL , Zhang G, Carbonell F, Correa JA, et al
    Reconstruction of rat retinal progenitor cell lineages in vitro reveals a surprising degree of stochasticity in cell fate decisions.
    Development. 2011;138:227-35.
    PubMed     Text format     Related articles    Abstract available



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