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The Medical Article of the Year 2008:
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78.
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Articles published in J Immunol

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Single Articles


    June 2008
  1. CHORNY A , Anderson P, Gonzalez-Rey E, Delgado M, et al
    Ghrelin Protects against Experimental Sepsis by Inhibiting High-Mobility Group Box 1 Release and by Killing Bacteria.
    J Immunol. 2008;180:8369-77.
    PubMed     Related articles    Abstract available


    May 2008
  2. GAUTIER EL , Huby T, Saint-Charles F, Ouzilleau B, et al
    Enhanced dendritic cell survival attenuates lipopolysaccharide-induced immunosuppression and increases resistance to lethal endotoxic shock.
    J Immunol. 2008;180:6941-6.
    PubMed     Related articles    Abstract available


  3. PACHOT A , Cazalis MA, Venet F, Turrel F, et al
    Decreased Expression of the Fractalkine Receptor CX3CR1 on Circulating Monocytes as New Feature of Sepsis-Induced Immunosuppression.
    J Immunol. 2008;180:6421-9.
    PubMed     Related articles    Abstract available


  4. ETOGO AO , Nunez J, Lin CY, Toliver-Kinsky TE, et al
    NK but Not CD1-Restricted NKT Cells Facilitate Systemic Inflammation during Polymicrobial Intra-Abdominal Sepsis.
    J Immunol. 2008;180:6334-45.
    PubMed     Related articles    Abstract available


  5. HENNEKE P , Dramsi S, Mancuso G, Chraibi K, et al
    Lipoproteins Are Critical TLR2 Activating Toxins in Group B Streptococcal Sepsis.
    J Immunol. 2008;180:6149-58.
    PubMed     Related articles    Abstract available


  6. CALAROTA SA , Foli A, Maserati R, Baldanti F, et al
    HIV-1-Specific T Cell Precursors with High Proliferative Capacity Correlate with Low Viremia and High CD4 Counts in Untreated Individuals.
    J Immunol. 2008;180:5907-15.
    PubMed     Related articles    Abstract available


    April 2008
  7. REN Y , Xie Y, Jiang G, Fan J, et al
    Apoptotic cells protect mice against lipopolysaccharide-induced shock.
    J Immunol. 2008;180:4978-85.
    PubMed     Related articles    Abstract available


    February 2008
  8. FALASCA L , Farrace MG, Rinaldi A, Tuosto L, et al
    Transglutaminase type II is involved in the pathogenesis of endotoxic shock.
    J Immunol. 2008;180:2616-24.
    PubMed     Related articles    Abstract available


  9. KIM HG , Kim NR, Gim MG, Lee JM, et al
    Lipoteichoic acid isolated from Lactobacillus plantarum inhibits lipopolysaccharide-induced TNF-alpha production in THP-1 cells and endotoxin shock in mice.
    J Immunol. 2008;180:2553-61.
    PubMed     Related articles    Abstract available


  10. WEI G , Tabel H
    Regulatory T cells prevent control of experimental African trypanosomiasis.
    J Immunol. 2008;180:2514-21.
    PubMed     Related articles    Abstract available


  11. XU XJ , Reichner JS, Mastrofrancesco B, Henry WL Jr, et al
    Prostaglandin E2 suppresses lipopolysaccharide-stimulated IFN-beta production.
    J Immunol. 2008;180:2125-31.
    PubMed     Related articles    Abstract available


    January 2008
  12. WONG KA , Rodriguez A
    Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells.
    J Immunol. 2008;180:716-26.
    PubMed     Related articles    Abstract available


  13. MIYAZAKI Y , Bunting M, Stafforini DM, Harris ES, et al
    Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections.
    J Immunol. 2008;180:590-600.
    PubMed     Related articles    Abstract available   Free Full Text


  14. MUELLER YM , Do DH, Altork SR, Artlett CM, et al
    IL-15 Treatment during Acute Simian Immunodeficiency Virus (SIV) Infection Increases Viral Set Point and Accelerates Disease Progression despite the Induction of Stronger SIV-Specific CD8+ T Cell Responses.
    J Immunol. 2008;180:350-60.
    PubMed     Related articles    Abstract available


    December 2007
  15. GROESDONK HV , Wagner F, Hoffarth B, Georgieff M, et al
    Enhancement of NF-{kappa}B Activation in Lymphocytes Prevents T Cell Apoptosis and Improves Survival in Murine Sepsis.
    J Immunol. 2007;179:8083-9.
    PubMed     Related articles    Abstract available


  16. PACHECO P , Vieira-de-Abreu A, Gomes RN, Barbosa-Lima G, et al
    Monocyte chemoattractant protein-1/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response.
    J Immunol. 2007;179:8500-8.
    PubMed     Related articles    Abstract available


  17. ILIOPOULOU BP , Alroy J, Huber BT
    CD28 deficiency exacerbates joint inflammation upon Borrelia burgdorferi infection, resulting in the development of chronic Lyme arthritis.
    J Immunol. 2007;179:8076-82.
    PubMed     Related articles    Abstract available


    November 2007
  18. VAN 'T VEER C , van den Pangaart PS, van Zoelen MA, de Kruif M, et al
    Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model.
    J Immunol. 2007;179:7110-20.
    PubMed     Related articles    Abstract available


  19. MIKSA M , Wu R, Cui X, Dong W, et al
    Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gamma.
    J Immunol. 2007;179:6263-72.
    PubMed     Related articles    Abstract available


  20. DAUBEUF B , Mathison J, Spiller S, Hugues S, et al
    TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock.
    J Immunol. 2007;179:6107-14.
    PubMed     Related articles    Abstract available


    October 2007
  21. BAFICA A , Feng CG, Santiago HC, Aliberti J, et al
    The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.
    J Immunol. 2007;179:5514-22.
    PubMed     Related articles    Abstract available


  22. ATSUMI T , Cho YR, Leng L, McDonald C, et al
    The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation.
    J Immunol. 2007;179:5399-406.
    PubMed     Related articles    Abstract available


  23. TILI E , Michaille JJ, Cimino A, Costinean S, et al
    Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-alpha stimulation and their possible roles in regulating the response to endotoxin shock.
    J Immunol. 2007;179:5082-9.
    PubMed     Related articles    Abstract available


    September 2007
  24. ZHANG H , Hegde A, Ng SW, Adhikari S, et al
    Hydrogen sulfide up-regulates substance p in polymicrobial sepsis-associated lung injury.
    J Immunol. 2007;179:4153-60.
    PubMed     Related articles    Abstract available


  25. LIU D , Lu F, Qin G, Fernandes SM, et al
    C1 inhibitor-mediated protection from sepsis.
    J Immunol. 2007;179:3966-72.
    PubMed     Related articles    Abstract available


  26. BEJON P , Mwacharo J, Kai O, Todryk S, et al
    The Induction and Persistence of T Cell IFN-{gamma} Responses after Vaccination or Natural Exposure Is Suppressed by Plasmodium falciparum.
    J Immunol. 2007;179:4193-201.
    PubMed     Related articles    Abstract available


  27. LIU G , Tsuruta Y, Gao Z, Park YJ, et al
    Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity.
    J Immunol. 2007;179:4125-34.
    PubMed     Related articles    Abstract available


  28. HORIUCHI K , Kimura T, Miyamoto T, Takaishi H, et al
    Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock.
    J Immunol. 2007;179:2686-9.
    PubMed     Related articles    Abstract available


    August 2007
  29. CHEHIMI J , Azzoni L, Farabaugh M, Creer SA, et al
    Baseline Viral Load and Immune Activation Determine the Extent of Reconstitution of Innate Immune Effectors in HIV-1-Infected Subjects Undergoing Antiretroviral Treatment.
    J Immunol. 2007;179:2642-50.
    PubMed     Related articles    Abstract available


  30. TURCOTTE K , Gauthier S, Malo D, Tam M, et al
    Icsbp1/IRF-8 is required for innate and adaptive immune responses against intracellular pathogens.
    J Immunol. 2007;179:2467-76.
    PubMed     Related articles    Abstract available


  31. PASCAL V , Yamada E, Martin MP, Alter G, et al
    Detection of KIR3DS1 on the Cell Surface of Peripheral Blood NK Cells Facilitates Identification of a Novel Null Allele and Assessment of KIR3DS1 Expression during HIV-1 Infection.
    J Immunol. 2007;179:1625-33.
    PubMed     Related articles    Abstract available


    July 2007
  32. OSUCHOWSKI MF , Welch K, Yang H, Siddiqui J, et al
    Chronic sepsis mortality characterized by an individualized inflammatory response.
    J Immunol. 2007;179:623-30.
    PubMed     Related articles    Abstract available


  33. HARZENETTER MD , Novotny AR, Gais P, Molina CA, et al
    Negative regulation of TLR responses by the neuropeptide CGRP is mediated by the transcriptional repressor ICER.
    J Immunol. 2007;179:607-15.
    PubMed     Related articles    Abstract available


  34. ASHARE A , Monick MM, Nymon AB, Morrison JM, et al
    Pseudomonas aeruginosa delays Kupffer cell death via stabilization of the X-chromosome-linked inhibitor of apoptosis protein.
    J Immunol. 2007;179:505-13.
    PubMed     Related articles    Abstract available


    June 2007
  35. PEYSSONNAUX C , Cejudo-Martin P, Doedens A, Zinkernagel AS, et al
    Cutting Edge: Essential Role of Hypoxia Inducible Factor-1{alpha} in Development of Lipopolysaccharide-Induced Sepsis.
    J Immunol. 2007;178:7516-9.
    PubMed     Related articles    Abstract available


  36. ALTER G , Suscovich TJ, Teigen N, Meier A, et al
    Single-Stranded RNA Derived from HIV-1 Serves as a Potent Activator of NK Cells.
    J Immunol. 2007;178:7658-66.
    PubMed     Related articles    Abstract available


  37. HABIB M , Rivas MN, Chamekh M, Wieckowski S, et al
    Cutting Edge: Small Molecule CD40 Ligand Mimetics Promote Control of Parasitemia and Enhance T Cells Producing IFN-{gamma} during Experimental Trypanosoma cruzi Infection.
    J Immunol. 2007;178:6700-6704.
    PubMed     Related articles    Abstract available


    May 2007
  38. VIGARIO AM , Belnoue E, Gruner AC, Mauduit M, et al
    Recombinant Human IFN-{alpha} Inhibits Cerebral Malaria and Reduces Parasite Burden in Mice.
    J Immunol. 2007;178:6416-6425.
    PubMed     Related articles    Abstract available


  39. WRANN CD , Tabriz NA, Barkhausen T, Klos A, et al
    The Phosphatidylinositol 3-Kinase Signaling Pathway Exerts Protective Effects during Sepsis by Controlling C5a-Mediated Activation of Innate Immune Functions.
    J Immunol. 2007;178:5940-8.
    PubMed     Related articles    Abstract available


    April 2007
  40. LO PASSO C , Romeo A, Pernice I, Donato P, et al
    Peptide mimics of the group B meningococcal capsule induce bactericidal and protective antibodies after immunization.
    J Immunol. 2007;178:4417-23.
    PubMed     Related articles    Abstract available


    March 2007
  41. LI W , Li J, Ashok M, Wu R, et al
    A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1.
    J Immunol. 2007;178:3856-64.
    PubMed     Related articles    Abstract available


  42. PATEL SN , Lu Z, Ayi K, Serghides L, et al
    Disruption of CD36 Impairs Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol and Confers Susceptibility to Severe and Fatal Malaria In Vivo.
    J Immunol. 2007;178:3954-61.
    PubMed     Related articles    Abstract available


  43. HRYNIEWICZ A , Price DA, Moniuszko M, Boasso A, et al
    Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virusmac251-infected macaques.
    J Immunol. 2007;178:3492-504.
    PubMed     Related articles    Abstract available


  44. NOOH MM , El-Gengehi N, Kansal R, David CS, et al
    HLA Transgenic Mice Provide Evidence for a Direct and Dominant Role of HLA Class II Variation in Modulating the Severity of Streptococcal Sepsis.
    J Immunol. 2007;178:3076-83.
    PubMed     Related articles    Abstract available


  45. MANCUSO G , Midiri A, Biondo C, Beninati C, et al
    Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria.
    J Immunol. 2007;178:3126-33.
    PubMed     Related articles    Abstract available


    February 2007
  46. RUPPRECHT TA , Angele B, Klein M, Heesemann J, et al
    Complement C1q and C3 Are Critical for the Innate Immune Response to Streptococcus pneumoniae in the Central Nervous System.
    J Immunol. 2007;178:1861-9.
    PubMed     Related articles    Abstract available


  47. DE KRUIF MD , Lemaire LC, Giebelen IA, van Zoelen MA, et al
    Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia.
    J Immunol. 2007;178:1845-51.
    PubMed     Related articles    Abstract available


    January 2007
  48. KNAPP S , Matt U, Leitinger N, van der Poll T, et al
    Oxidized phospholipids inhibit phagocytosis and impair outcome in gram-negative sepsis in vivo.
    J Immunol. 2007;178:993-1001.
    PubMed     Related articles    Abstract available


    December 2006
  49. BU HF , Wang X, Zhu YQ, Williams RY, et al
    Lysozyme-Modified Probiotic Components Protect Rats against Polymicrobial Sepsis: Role of Macrophages and Cathelicidin-Related Innate Immunity.
    J Immunol. 2006;177:8767-8776.
    PubMed     Related articles    Abstract available


  50. IMAMURA T , Kobayashi H, Khan R, Nitta H, et al
    Induction of vascular leakage and blood pressure lowering through kinin release by a serine proteinase from Aeromonas sobria.
    J Immunol. 2006;177:8723-9.
    PubMed     Related articles    Abstract available


  51. WATANABE H , Kubo M, Numata K, Takagi K, et al
    Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis.
    J Immunol. 2006;177:8650-7.
    PubMed     Related articles    Abstract available


  52. UNSINGER J , Herndon JM, Davis CG, Muenzer JT, et al
    The Role of TCR Engagement and Activation-Induced Cell Death in Sepsis-Induced T Cell Apoptosis.
    J Immunol. 2006;177:7968-73.
    PubMed     Related articles    Abstract available


  53. SCUMPIA PO , Delano MJ, Kelly KM, O'malley KA, et al
    Increased Natural CD4+CD25+ Regulatory T Cells and Their Suppressor Activity Do Not Contribute to Mortality in Murine Polymicrobial Sepsis.
    J Immunol. 2006;177:7943-9.
    PubMed     Related articles    Abstract available


    November 2006
  54. VENET F , Pachot A, Debard AL, Bohe J, et al
    Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism.
    J Immunol. 2006;177:6540-7.
    PubMed     Related articles    Abstract available


  55. MARRIOTT HM , Hellewell PG, Cross SS, Ince PG, et al
    Decreased alveolar macrophage apoptosis is associated with increased pulmonary inflammation in a murine model of pneumococcal pneumonia.
    J Immunol. 2006;177:6480-8.
    PubMed     Related articles    Abstract available


    October 2006
  56. WEIGHARDT H , Kaiser-Moore S, Schlautkotter S, Rossmann-Bloeck T, et al
    Type I IFN modulates host defense and late hyperinflammation in septic peritonitis.
    J Immunol. 2006;177:5623-30.
    PubMed     Related articles    Abstract available


  57. GARREAN S , Gao XP, Brovkovych V, Shimizu J, et al
    Caveolin-1 Regulates NF-{kappa}B Activation and Lung Inflammatory Response to Sepsis Induced by Lipopolysaccharide.
    J Immunol. 2006;177:4853-60.
    PubMed     Related articles    Abstract available


  58. NADIRI A , Wolinski MK, Saleh M
    The inflammatory caspases: key players in the host response to pathogenic invasion and sepsis.
    J Immunol. 2006;177:4239-45.
    PubMed     Related articles    Abstract available


    September 2006
  59. MORENO SE , Alves-Filho JC, Alfaya TM, da Silva JS, et al
    IL-12, but Not IL-18, Is Critical to Neutrophil Activation and Resistance to Polymicrobial Sepsis Induced by Cecal Ligation and Puncture.
    J Immunol. 2006;177:3218-24.
    PubMed     Related articles    Abstract available


    August 2006
  60. OSUCHOWSKI MF , Welch K, Siddiqui J, Remick DG, et al
    Circulating Cytokine/Inhibitor Profiles Reshape the Understanding of the SIRS/CARS Continuum in Sepsis and Predict Mortality.
    J Immunol. 2006;177:1967-74.
    PubMed     Related articles    Abstract available


    July 2006
  61. GUO RF , Riedemann NC, Sun L, Gao H, et al
    Divergent Signaling Pathways in Phagocytic Cells during Sepsis.
    J Immunol. 2006;177:1306-13.
    PubMed     Related articles    Abstract available


  62. MORENO SE , Alves-Filho JC, Rios-Santos F, Silva JS, et al
    Signaling via Platelet-Activating Factor Receptors Accounts for the Impairment of Neutrophil Migration in Polymicrobial Sepsis.
    J Immunol. 2006;177:1264-71.
    PubMed     Related articles    Abstract available


  63. RENCKENS R , Roelofs JJ, Florquin S, de Vos AF, et al
    Endogenous Tissue-Type Plasminogen Activator Is Protective during Escherichia coli-Induced Abdominal Sepsis in Mice.
    J Immunol. 2006;177:1189-96.
    PubMed     Related articles    Abstract available


  64. SCHWULST SJ , Grayson MH, Dipasco PJ, Davis CG, et al
    Agonistic Monoclonal Antibody Against CD40 Receptor Decreases Lymphocyte Apoptosis and Improves Survival in Sepsis.
    J Immunol. 2006;177:557-65.
    PubMed     Related articles    Abstract available


  65. JONSSON G , Oxelius VA, Truedsson L, Braconier JH, et al
    Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency.
    J Immunol. 2006;177:722-8.
    PubMed     Related articles    Abstract available


    May 2006
  66. NEMETH ZH , Csoka B, Wilmanski J, Xu D, et al
    Adenosine A2A Receptor Inactivation Increases Survival in Polymicrobial Sepsis.
    J Immunol. 2006;176:5616-26.
    PubMed     Related articles    Abstract available


  67. HOTCHKISS RS , McConnell KW, Bullok K, Davis CG, et al
    TAT-BH4 and TAT-Bcl-xL Peptides Protect against Sepsis-Induced Lymphocyte Apoptosis In Vivo.
    J Immunol. 2006;176:5471-7.
    PubMed     Related articles    Abstract available


    April 2006
  68. AKASHI-TAKAMURA S , Furuta T, Takahashi K, Tanimura N, et al
    Agonistic Antibody to TLR4/MD-2 Protects Mice from Acute Lethal Hepatitis Induced by TNF-{alpha}.
    J Immunol. 2006;176:4244-51.
    PubMed     Related articles    Abstract available


    February 2006
  69. MOLLER-KRISTENSEN M , Ip WK, Shi L, Gowda LD, et al
    Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa.
    J Immunol. 2006;176:1769-75.
    PubMed     Related articles    Abstract available


    December 2005
  70. SANTIAGO HC , Feng CG, Bafica A, Roffe E, et al
    Mice Deficient in LRG-47 Display Enhanced Susceptibility to Trypanosoma cruzi Infection Associated with Defective Hemopoiesis and Intracellular Control of Parasite Growth.
    J Immunol 2005;175:8165-72.
    PubMed     Related articles    Abstract available


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