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The Medical Article of the Year 2008:
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78.
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Articles published in Crit Care Med

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Single Articles


    September 2008
  1. SILVESTRI L , van Saene HK, de la Cal MA, Zandstra DF, et al
    Surviving Sepsis Campaign needed consensus to exclude selective decontamination of the digestive tract.
    Crit Care Med. 2008;36:2716-7.
    PubMed     Related articles   


  2. FERNANDES CJ JR , Campos AH
    Sepsis-induced myocardial depression and calcium mishandling: an acceptable unifying theory?
    Crit Care Med. 2008;36:2695-6.
    PubMed     Related articles   


  3. MZAYEK F , Ylostalo J, Krogstad DJ
    Apoptosis of endothelial cells in bacterial sepsis and severe Plasmodium falciparum malaria: do we know enough to consider clinical trials?
    Crit Care Med. 2008;36:2690-2.
    PubMed     Related articles   


  4. HOFFMANN U , Brueckmann M
    A new language of natriuretic peptides in sepsis?
    Crit Care Med. 2008;36:2686-7.
    PubMed     Related articles   


    August 2008
  5. ANGUS DC , Annane D, Sprung CL, Randolph AG, et al
    New recommendations for the use of corticosteroids in sepsis: Not so fast!
    Crit Care Med. 2008;36:2490.
    PubMed     Related articles   


  6. SEELING M , Eggers V, Spies C
    Surviving sepsis campaign: guideline clarification.
    Crit Care Med. 2008;36:2490.
    PubMed     Related articles   


  7. LEVY MM , Vincent JL, Jaeschke R, Parker MM, et al
    Surviving Sepsis Campaign: Guideline Clarification.
    Crit Care Med. 2008;36:2490-2491.
    PubMed     Related articles   


  8. SALLUH JI , Soares M
    New recommendations for the use of corticosteroids in sepsis: Not so fast!
    Crit Care Med. 2008;36:2489-90.
    PubMed     Related articles   


  9. DUNSER MW , Dunser WR
    Surviving Sepsis Campaign Guidelines 2008: Revisiting vasopressor recommendations.
    Crit Care Med. 2008;36:2488.
    PubMed     Related articles   


  10. VINCENT JL , Hollenberg SM, Rivers E, Levy MM, et al
    Surviving Sepsis Campaign Guidelines 2008: Revisiting vasopressor recommendations.
    Crit Care Med. 2008;36:2488-2489.
    PubMed     Related articles   


  11. CHENG AC , West TE, Peacock SJ
    Surviving sepsis in developing countries.
    Crit Care Med. 2008;36:2487.
    PubMed     Related articles   


  12. DELLINGER RP , Vincent JL, Silva E, Townsend S, et al
    Surviving sepsis in developing countries.
    Crit Care Med. 2008;36:2487-2488.
    PubMed     Related articles   


  13. KNUEFERMANN P , Boehm O, Baumgarten G, Zacharowski K, et al
    Sepsis-induced vasoplegia-Is vasopressin V1A-receptor a new target?
    Crit Care Med. 2008;36:2468-9.
    PubMed     Related articles   


  14. SPAPEN HD
    The glycemia threat in sepsis: Too high, too low, or too ... variable!
    Crit Care Med. 2008;36:2459-60.
    PubMed     Related articles   


  15. HUET O , Cherreau C, Nicco C, Dupic L, et al
    Pivotal role of glutathione depletion in plasma-induced endothelial oxidative stress during sepsis.
    Crit Care Med. 2008;36:2328-34.
    PubMed     Related articles    Abstract available


  16. INOUE Y , Chen Y, Pauzenberger R, Mark HI, et al
    Hypertonic saline up-regulates A3 adenosine receptors expression of activated neutrophils and increases acute lung injury after sepsis.
    Crit Care Med. 2008.
    PubMed     Related articles    Abstract available


  17. CIRIONI O , Ghiselli R, Orlando F, Silvestri C, et al
    Efficacy of the amphibian peptide distinctin in a neutropenic mouse model of staphylococcal sepsis.
    Crit Care Med. 2008.
    PubMed     Related articles    Abstract available


  18. HEMMER CJ , Vogt A, Unverricht M, Krause R, et al
    Malaria and bacterial sepsis: Similar mechanisms of endothelial apoptosis and its prevention in vitro.
    Crit Care Med. 2008.
    PubMed     Related articles    Abstract available


  19. BIESALSKI HK
    Parenteral ascorbic acid as a key for regulating microcirculation in critically ill.
    Crit Care Med. 2008;36:2466-8.
    PubMed     Related articles   


  20. HUISSE MG , Pease S, Hurtado-Nedelec M, Arnaud B, et al
    Leukocyte activation: the link between inflammation and coagulation during heatstroke. A study of patients during the 2003 heat wave in Paris.
    Crit Care Med. 2008;36:2288-95.
    PubMed     Related articles    Abstract available


  21. SCHMIDT C , Hocherl K, Kurt B, Bucher M, et al
    Role of nuclear factor-kappaB-dependent induction of cytokines in the regulation of vasopressin V1A-receptors during cecal ligation and puncture-induced circulatory failure.
    Crit Care Med. 2008;36:2363-72.
    PubMed     Related articles    Abstract available


  22. TYML K , Li F, Wilson JX
    Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism.
    Crit Care Med. 2008;36:2355-62.
    PubMed     Related articles    Abstract available


    July 2008
  23. ALI NA , O'brien JM Jr, Dungan K, Phillips G, et al
    Glucose variability and mortality in patients with sepsis.
    Crit Care Med. 2008;.
    PubMed     Related articles    Abstract available


  24. SALLUH JI , Bozza PT
    Biomarkers of sepsis: lost in translation?
    Crit Care Med. 2008;36:2192-4.
    PubMed     Related articles   


  25. PLOTZ FB
    Importance of follow-up research in children surviving meningococcal septic shock.
    Crit Care Med. 2008;36:2217.
    PubMed     Related articles   


  26. MURRAY CK
    Infectious disease complications of combat-related injuries.
    Crit Care Med. 2008;36.
    PubMed     Related articles    Abstract available


    June 2008
  27. SAKR Y , Burgett U, Nacul FE, Reinhart K, et al
    Lipopolysaccharide binding protein in a surgical intensive care unit: A marker of sepsis?
    Crit Care Med. 2008;.
    PubMed     Related articles    Abstract available


  28. OFFENSTADT G , Maury E
    Upper gastrointestinal bleeding in severe sepsis.
    Crit Care Med. 2008;36:1990-1.
    PubMed     Related articles   


  29. ERTMER C , Morelli A, Westphal M
    Calcium sensitizing in sepsis: is levosimendan on the right path?
    Crit Care Med. 2008;36:1981-2.
    PubMed     Related articles   


  30. ROSSIGNOL B , Gueret G, Pennec JP, Morel J, et al
    Effects of chronic sepsis on contractile properties of fast twitch muscle in an experimental model of critical illness neuromyopathy in the rat.
    Crit Care Med. 2008;36:1855-63.
    PubMed     Related articles    Abstract available


  31. SCHMIDT H , Muller-Werdan U, Werdan K
    Assessment of vagal activity during transcutaneous vagus nerve stimulation in mice.
    Crit Care Med. 2008;36:1990.
    PubMed     Related articles   


  32. DELLINGER RP
    Steroid therapy of septic shock: the decision is in the eye of the beholder.
    Crit Care Med. 2008;36:1987-9.
    PubMed     Related articles   


  33. ERTMER C , Westphal M, Morelli A
    Levo is in the air: take a deep breath!
    Crit Care Med. 2008;36:1979-81.
    PubMed     Related articles   


  34. DUBICK MA
    A treatment worth its salt?
    Crit Care Med. 2008;36:1978-9.
    PubMed     Related articles   


  35. YOUNG GB
    Critical illness myopathy: deeper insights.
    Crit Care Med. 2008;36:1977.
    PubMed     Related articles   


  36. EACHEMPATI SR
    Gender differences after hemorrhagic shock from blunt trauma: what is helping the women?
    Crit Care Med. 2008;36:1976.
    PubMed     Related articles   


  37. MARIK PE
    Death by TPN... the final chapter?
    Crit Care Med. 2008;36:1964-5.
    PubMed     Related articles   


  38. WERNERMAN J
    Growth hormone to catabolic patients revisited.
    Crit Care Med. 2008;36:1952-3.
    PubMed     Related articles   


  39. BEALE R
    Echoes of the past?
    Crit Care Med. 2008;36:1950-1.
    PubMed     Related articles   


  40. SHIH CC , Chen SJ, Chen A, Wu JY, et al
    Therapeutic effects of hypertonic saline on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats.
    Crit Care Med. 2008;36:1864-72.
    PubMed     Related articles    Abstract available


  41. ELKE G , Schadler D, Engel C, Bogatsch H, et al
    Current practice in nutritional support and its association with mortality in septic patients--results from a national, prospective, multicenter study.
    Crit Care Med. 2008;36:1762-7.
    PubMed     Related articles    Abstract available


  42. FRIES M , Ince C, Rossaint R, Bleilevens C, et al
    Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock.
    Crit Care Med. 2008;36:1886-91.
    PubMed     Related articles    Abstract available


    May 2008
  43. D'AVILA JD , Santiago AP, Amancio RT, Galina A, et al
    Sepsis induces brain mitochondrial dysfunction.
    Crit Care Med. 2008;.
    PubMed     Related articles    Abstract available


  44. CHRIST-CRAIN M , Muller B
    Calcitonin peptides--the mediators in sepsis or just another fairy tale?
    Crit Care Med. 2008;36:1684-7.
    PubMed     Related articles   


  45. ALSTON TA
    Teasing and skinning muscles in sepsis research.
    Crit Care Med. 2008;36:1674-5.
    PubMed     Related articles   


  46. GORDON A , Knight JC, Hinds CJ
    Genes and sepsis: how tight is the fit?
    Crit Care Med. 2008;36:1652-4.
    PubMed     Related articles   


  47. ALI NA
    Moving toward preventive therapy in acute lung injury.
    Crit Care Med. 2008;36:1666-7.
    PubMed     Related articles   


  48. FALAGAS ME , Tassios PT
    Enhanced and earlier detection of bacteremia and fungemia by multiplex polymerase chain reaction: how much enhanced, how much earlier, and at what cost?
    Crit Care Med. 2008;36:1660-1.
    PubMed     Related articles   


  49. DONATI A , Preiser JC
    Corticosteroids and septic shock: a new episode of a never-ceasing story?
    Crit Care Med. 2008;36:1658-9.
    PubMed     Related articles   


  50. GU W , Du DY, Huang J, Zhang LY, et al
    Identification of interleukin-6 promoter polymorphisms in the Chinese Han population and their functional significance.
    Crit Care Med. 2008;36:1437-43.
    PubMed     Related articles    Abstract available


  51. ISCIMEN R , Cartin-Ceba R, Yilmaz M, Khan H, et al
    Risk factors for the development of acute lung injury in patients with septic shock: an observational cohort study.
    Crit Care Med. 2008;36:1518-22.
    PubMed     Related articles    Abstract available


  52. LOUIE RF , Tang Z, Albertson TE, Cohen S, et al
    Multiplex polymerase chain reaction detection enhancement of bacteremia and fungemia.
    Crit Care Med. 2008;36:1487-92.
    PubMed     Related articles    Abstract available


  53. PENG ZY , Carter MJ, Kellum JA
    Effects of hemoadsorption on cytokine removal and short-term survival in septic rats.
    Crit Care Med. 2008;36:1573-7.
    PubMed     Related articles    Abstract available


    April 2008
  54. ZAKARIAH AN , Cozzi SM, Nuffelen MV, Clausi CM, et al
    Combination of biphasic transmittance waveform with blood procalcitonin levels for diagnosis of sepsis in acutely ill patients.
    Crit Care Med. 2008;.
    PubMed     Related articles    Abstract available


  55. SEXTON PM , Christopoulos G, Christopoulos A, Nylen ES, et al
    Procalcitonin has bioactivity at calcitonin receptor family complexes: Potential mediator implications in sepsis*
    Crit Care Med. 2008;.
    PubMed     Related articles    Abstract available


  56. ZINK W , Kaess M, Hofer S, Plachky J, et al
    Alterations in intracellular Ca2+-homeostasis of skeletal muscle fibers during sepsis.
    Crit Care Med. 2008;.
    PubMed     Related articles    Abstract available


  57. MENGES T , Konig IR, Hossain H, Little S, et al
    Sepsis syndrome and death in trauma patients are associated with variation in the gene encoding tumor necrosis factor*
    Crit Care Med. 2008;.
    PubMed     Related articles    Abstract available


  58. ABOAB J , Polito A, Orlikowski D, Sharshar T, et al
    Hydrocortisone effects on cardiovascular variability in septic shock: A spectral analysis approach.
    Crit Care Med. 2008;.
    PubMed     Related articles    Abstract available


  59. LANGE M , Hamahata A, Enkhbaatar P, Esechie A, et al
    Assessment of vascular permeability in an ovine model of acute lung injury and pneumonia-induced Pseudomonas aeruginosa sepsis.
    Crit Care Med. 2008;36:1284-9.
    PubMed     Related articles    Abstract available


  60. TALMOR D , Greenberg D, Howell MD, Lisbon A, et al
    The costs and cost-effectiveness of an integrated sepsis treatment protocol.
    Crit Care Med. 2008;36:1168-74.
    PubMed     Related articles    Abstract available


  61. TANG BM , McLean AS, Dawes IW, Huang SJ, et al
    Gene-expression profiling of gram-positive and gram-negative sepsis in critically ill patients.
    Crit Care Med. 2008;36:1125-8.
    PubMed     Related articles    Abstract available


  62. WAN L , Bagshaw SM, Langenberg C, Saotome T, et al
    Pathophysiology of septic acute kidney injury: what do we really know?
    Crit Care Med. 2008;36.
    PubMed     Related articles    Abstract available


  63. TENHUNEN JJ
    Bull's eye missed by the magic bullet: preclinical investigations, publication bias, and promising new interventions.
    Crit Care Med. 2008;36:1361-3.
    PubMed     Related articles   


  64. WHEELER DS , Devarajan P, Ma Q, Harmon K, et al
    Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock.
    Crit Care Med. 2008;36:1297-303.
    PubMed     Related articles    Abstract available


  65. HOPKINS PA , Pridmore AC, Ellmerich S, Fraser JD, et al
    Increased surface toll-like receptor 2 expression in superantigen shock.
    Crit Care Med. 2008;36:1267-76.
    PubMed     Related articles    Abstract available


  66. AMOUR J , Birenbaum A, Langeron O, Le Manach Y, et al
    Influence of renal dysfunction on the accuracy of procalcitonin for the diagnosis of postoperative infection after vascular surgery.
    Crit Care Med. 2008;36:1147-54.
    PubMed     Related articles    Abstract available


  67. SU J , Li X, Cui X, Li Y, et al
    Ethyl pyruvate decreased early nuclear factor-kappaB levels but worsened survival in lipopolysaccharide-challenged mice.
    Crit Care Med. 2008;36:1059-67.
    PubMed     Related articles    Abstract available


    March 2008
  68. DORRESTEIJN MJ , van der Hoeven HG, Pickkers P
    Volume therapy and innate immune response during systemic inflammation or sepsis.
    Crit Care Med. 2008;36:1028.
    PubMed     Related articles   


  69. RIVERS EP
    Volume therapy and innate immune response during systemic inflammation or sepsis.
    Crit Care Med. 2008;36:1028-9.
    PubMed     Related articles   


  70. CHEATHAM ML
    Resuscitation end points in severe sepsis: Central venous pressure, mean arterial pressure, mixed venous oxygen saturation, and ... intra-abdominal pressure.
    Crit Care Med. 2008;36:1012-4.
    PubMed     Related articles   


  71. COHEN RI
    Sepsis-induced left ventricular diastolic dysfunction: Little time to relax.
    Crit Care Med. 2008;36:999-1000.
    PubMed     Related articles   


  72. CARLET J , Cohen J, Calandra T, Opal SM, et al
    Sepsis: time to reconsider the concept.
    Crit Care Med. 2008;36:964-6.
    PubMed     Related articles    Abstract available


  73. BECKER KL , Snider R, Nylen ES
    Procalcitonin assay in systemic inflammation, infection, and sepsis: Clinical utility and limitations.
    Crit Care Med. 2008;36:941-52.
    PubMed     Related articles    Abstract available


  74. LIN SM , Wang YM, Lin HC, Lee KY, et al
    Serum thrombomodulin level relates to the clinical course of disseminated intravascular coagulation, multiorgan dysfunction syndrome, and mortality in patients with sepsis.
    Crit Care Med. 2008;36:683-9.
    PubMed     Related articles    Abstract available


  75. BEISHUIZEN A , Girbes AR, Groeneveld AB
    Leptin and ghrelin: through thick and thin.
    Crit Care Med. 2008;36:1011-2.
    PubMed     Related articles   


  76. THOMAS KW
    Reevaluating prognosis: cancer, septic shock, and changing outcomes.
    Crit Care Med. 2008;36:987-8.
    PubMed     Related articles   


  77. KUROSAWA S , Stearns-Kurosawa DJ, Kinasewitz GT
    Soluble thrombomodulin: a sign of bad times.
    Crit Care Med. 2008;36:985-7.
    PubMed     Related articles   


  78. TSAO CM , Ho ST, Liaw WJ, Chen A, et al
    Combined effects of propofol and dexamethasone on rats with endotoxemia.
    Crit Care Med. 2008;36:887-94.
    PubMed     Related articles    Abstract available


  79. ANINAT C , Seguin P, Descheemaeker PN, Morel F, et al
    Catecholamines induce an inflammatory response in human hepatocytes.
    Crit Care Med. 2008;36:848-54.
    PubMed     Related articles    Abstract available


  80. YILMAZ Z , Ilcol YO, Ulus IH
    Endotoxin increases plasma leptin and ghrelin levels in dogs.
    Crit Care Med. 2008;36:828-33.
    PubMed     Related articles    Abstract available


  81. BOUHEMAD B , Nicolas-Robin A, Arbelot C, Arthaud M, et al
    Isolated and reversible impairment of ventricular relaxation in patients with septic shock.
    Crit Care Med. 2008;36:766-74.
    PubMed     Related articles    Abstract available


  82. PENE F , Percheron S, Lemiale V, Viallon V, et al
    Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit.
    Crit Care Med. 2008;36:690-6.
    PubMed     Related articles    Abstract available


  83. PENG ZY , Critchley LA, Joynt GM, Gruber PC, et al
    Effects of norepinephrine during intra-abdominal hypertension on renal blood flow in bacteremic dogs.
    Crit Care Med. 2008;36:834-41.
    PubMed     Related articles    Abstract available


    February 2008
  84. ROSSI MA , Celes MR
    Intercellular junctions in sepsis.
    Crit Care Med. 2008;36:660-661.
    PubMed     Related articles   


  85. SIRACUSANO L , Girasole V
    Intercellular junctions in sepsis.
    Crit Care Med. 2008;36:659-60.
    PubMed     Related articles   


  86. TOLEDO-PEREYRA LH
    Critical role of p38 mitogen protein kinase in sepsis.
    Crit Care Med. 2008;36:636-7.
    PubMed     Related articles   


  87. FODALE V , Santamaria LB
    Cholinesterase inhibitors improve survival in experimental sepsis: a new way to activate the cholinergic anti-inflammatory pathway.
    Crit Care Med. 2008;36:622-3.
    PubMed     Related articles   


  88. LORENTE L , Mora ML, Jimenez A
    Microorganisms responsible for femoral catheter-related bloodstream infection.
    Crit Care Med. 2008;36:657-8.
    PubMed     Related articles   


  89. FORCEVILLE X
    The need for precise dose information of sodium selenite in the SIC study and rectification of GPx-3 plasma concentration.
    Crit Care Med. 2008;36:656-7.
    PubMed     Related articles   


  90. BAUMGART K , Radermacher P, Calzia E, Hauser B, et al
    Pathophysiology of tissue acidosis in septic shock: blocked microcirculation or impaired cellular respiration?
    Crit Care Med. 2008;36:640-2.
    PubMed     Related articles   


  91. SCHULTZ MJ , Juffermans NP
    Maldistribution of interalveolar perfusion--one early step in the pathogenesis of lung injury?
    Crit Care Med. 2008;36:639-40.
    PubMed     Related articles   


  92. LEVERVE XM
    To cope with oxygen: a long and still tumultuous story for life.
    Crit Care Med. 2008;36:637-8.
    PubMed     Related articles   


  93. MERMEL LA
    Arterial catheters are not risk-free spigots.
    Crit Care Med. 2008;36:620-2.
    PubMed     Related articles   


  94. KEENE AB
    Thrombosis in central catheter-associated Staphylococcus aureus bacteremia: always scan the site?
    Crit Care Med. 2008;36:618-9.
    PubMed     Related articles   


  95. BUYSSE CM , Raat H, Hazelzet JA, Hop WC, et al
    Surviving meningococcal septic shock: health consequences and quality of life in children and their parents up to 2 years after pediatric intensive care unit discharge.
    Crit Care Med. 2008;36:596-602.
    PubMed     Related articles    Abstract available


  96. MURCH O , Abdelrahman M, Collino M, Gallicchio M, et al
    Sphingosylphosphorylcholine reduces the organ injury/dysfunction and inflammation caused by endotoxemia in the rat.
    Crit Care Med. 2008;36:550-9.
    PubMed     Related articles    Abstract available


  97. DUBIN A , Edul VS, Pozo MO, Murias G, et al
    Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxemia.
    Crit Care Med. 2008;36:535-42.
    PubMed     Related articles    Abstract available


  98. STEPHENS DP , Thomas JH, Higgins A, Bailey M, et al
    Randomized, double-blind, placebo-controlled trial of granulocyte colony-stimulating factor in patients with septic shock.
    Crit Care Med. 2008;36:448-54.
    PubMed     Related articles    Abstract available


  99. KOH DB , Gowardman JR, Rickard CM, Robertson IK, et al
    Prospective study of peripheral arterial catheter infection and comparison with concurrently sited central venous catheters.
    Crit Care Med. 2008;36:397-402.
    PubMed     Related articles    Abstract available


  100. QUARTIN AA , Calonge RO, Schein RM, Crandall LA, et al
    Influence of critical illness on physicians' prognoses for underlying disease: a randomized study using simulated cases.
    Crit Care Med. 2008;36:462-70.
    PubMed     Related articles    Abstract available


  101. BARTH E , Bassi G, Maybauer DM, Simon F, et al
    Effects of ventilation with 100% oxygen during early hyperdynamic porcine fecal peritonitis.
    Crit Care Med. 2008;36:495-503.
    PubMed     Related articles    Abstract available


  102. ASADUZZAMAN M , Wang Y, Thorlacius H
    Critical role of p38 mitogen-activated protein kinase signaling in septic lung injury.
    Crit Care Med. 2008;36:482-8.
    PubMed     Related articles    Abstract available


  103. CROWLEY AL , Peterson GE, Benjamin DK Jr, Rimmer SH, et al
    Venous thrombosis in patients with short- and long-term central venous catheter-associated Staphylococcus aureus bacteremia.
    Crit Care Med. 2008;36:385-90.
    PubMed     Related articles    Abstract available


    January 2008
  104. PREISER JC , De Backer D
    Novel insights into the effects of inducible nitric oxide synthase inhibition during sepsis.
    Crit Care Med. 2008;36:359-60.
    PubMed     Related articles   


  105. WADA H , Hatada T
    Pathophysiology and diagnostic criteria for disseminated intravascular coagulation associated with sepsis.
    Crit Care Med. 2008;36:348-9.
    PubMed     Related articles   


  106. DELLINGER RP , Levy MM, Carlet JM, Bion J, et al
    Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008.
    Crit Care Med. 2008;36:296-327.
    PubMed     Related articles    Abstract available


  107. WHEELER A , Steingrub J, Schmidt GA, Sanchez P, et al
    A retrospective observational study of drotrecogin alfa (activated) in adults with severe sepsis: Comparison with a controlled clinical trial.
    Crit Care Med. 2008;36:14-23.
    PubMed     Related articles    Abstract available


  108. DOIG G
    Effectiveness of drotrecogin alfa (activated) in clinical practice: a stitch in time.
    Crit Care Med. 2008;36:332-3.
    PubMed     Related articles   


  109. GHISELLI R , Giacometti A, Cirioni O, Mocchegiani F, et al
    Efficacy of the bovine antimicrobial peptide indolicidin combined with piperacillin/tazobactam in experimental rat models of polymicrobial peritonitis.
    Crit Care Med. 2008;36:240-5.
    PubMed     Related articles    Abstract available


  110. MAYR FB , Spiel AO, Leitner JM, Firbas C, et al
    Duffy antigen modifies the chemokine response in human endotoxemia.
    Crit Care Med. 2008;36:159-65.
    PubMed     Related articles    Abstract available


  111. OMLAND T
    Advances in congestive heart failure management in the intensive care unit: B-type natriuretic peptides in evaluation of acute heart failure.
    Crit Care Med. 2008;36.
    PubMed     Related articles    Abstract available


    December 2007
  112. SANKOFF JD , Goyal M, Gaieski DF, Dietch K, et al
    Validation of the Mortality in Emergency Department Sepsis (MEDS) score in patients with the systemic inflammatory response syndrome (SIRS)*
    Crit Care Med. 2007;.
    PubMed     Related articles    Abstract available


  113. HOFER S , Eisenbach C, Lukic IK, Schneider L, et al
    Pharmacologic cholinesterase inhibition improves survival in experimental sepsis*
    Crit Care Med. 2007;.
    PubMed     Related articles    Abstract available


  114. CONHAIM RL , Watson KE, Spiegel CA, Dovi WF, et al
    Bacteremic sepsis disturbs alveolar perfusion distribution in the lungs of rats*
    Crit Care Med. 2007;.
    PubMed     Related articles    Abstract available


  115. BAUHOFER A , Torossian A
    Mechanical vagus nerve stimulation-A new adjunct in sepsis prophylaxis and treatment?
    Crit Care Med. 2007;35:2868-9.
    PubMed     Related articles   


  116. NEUGEBAUER EA
    To use or not to use? Polyclonal intravenous immunoglobulins for the treatment of sepsis and septic shock.
    Crit Care Med. 2007;35:2855-6.
    PubMed     Related articles   


  117. FIDAN H , Sahin O, Yavuz Y, Kilbas A, et al
    Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats.
    Crit Care Med. 2007;35:2822-9.
    PubMed     Related articles    Abstract available


  118. BELIKOVA I , Lukaszewicz AC, Faivre V, Damoisel C, et al
    Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis.
    Crit Care Med. 2007;35:2702-8.
    PubMed     Related articles    Abstract available


  119. WERDAN K , Pilz G, Bujdoso O, Fraunberger P, et al
    Score-based immunoglobulin G therapy of patients with sepsis: the SBITS study.
    Crit Care Med. 2007;35:2693-2701.
    PubMed     Related articles    Abstract available


  120. LAUPLAND KB , Kirkpatrick AW, Delaney A
    Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: a systematic review and meta-analysis.
    Crit Care Med. 2007;35:2686-92.
    PubMed     Related articles    Abstract available


  121. KREYMANN KG , de Heer G, Nierhaus A, Kluge S, et al
    Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock.
    Crit Care Med. 2007;35:2677-85.
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  122. EICHACKER PQ , Natanson C, Danner RL
    Separating practice guidelines from pharmaceutical marketing.
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  123. CROUSER ED
    Suppression of monocyte metabolism by septic plasma: revisiting the concept of "blood poisoning".
    Crit Care Med. 2007;35:2856-7.
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  124. WERDAN K
    Mirror, mirror on the wall, which is the fairest meta-analysis of all?
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  125. VAN ZOELEN MA , Laterre PF, van Veen SQ, van Till JW, et al
    Systemic and local high mobility group box 1 concentrations during severe infection.
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  126. KOCH A , Boehm O, Zacharowski PA, Loer SA, et al
    Inducible nitric oxide synthase and heme oxygenase-1 in the lung during lipopolysaccharide tolerance and cross tolerance.
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    November 2007
  127. BEALE RJ , Sherry T, Lei K, Campbell-Stephen L, et al
    Early enteral supplementation with key pharmaconutrients improves Sequential Organ Failure Assessment score in critically ill patients with sepsis: Outcome of a randomized, controlled, double-blind trial.
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  128. BROMBERG Z , Raj N, Goloubinoff P, Deutschman CS, et al
    Enhanced expression of 70-kilodalton heat shock protein limits cell division in a sepsis-induced model of acute respiratory distress syndrome*
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  129. RANJAN D
    Industry support and sepsis guidelines.
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  130. DURBIN CG JR
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  131. CORNET AD , Beishuizen A, Groeneveld AB
    Activated protein C in sepsis: Tightening pulmonary endothelial cells?
    Crit Care Med. 2007;35:2656-2658.
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  132. CRIBBS SK , Martin GS
    Expanding the global epidemiology of sepsis.
    Crit Care Med. 2007;35:2646-2648.
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  133. CARLSON DE , Chiu WC, Johnson SB, Scalea TM, et al
    Barriers to the optimal resuscitation of patients with severe sepsis? Transfer to a level I critical care center!
    Crit Care Med. 2007;35:2644-2645.
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  134. CARLBOM DJ , Rubenfeld GD
    Barriers to implementing protocol-based sepsis resuscitation in the emergency department-Results of a national survey.
    Crit Care Med. 2007;35:2525-2532.
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  135. WANG Z , Su F, Rogiers P, Vincent JL, et al
    Beneficial effects of recombinant human activated protein C in a ewe model of septic shock.
    Crit Care Med. 2007;35:2594-600.
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    October 2007
  136. KREYMANN KG , de Heer G, Nierhaus A, Kluge S, et al
    Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock*
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  137. WERDAN K , Pilz G, Bujdoso O, Fraunberger P, et al
    Score-based immunoglobulin G therapy of patients with sepsis: The SBITS study*
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  138. LAUPLAND KB , Kirkpatrick AW, Delaney A
    Polyclonal intravenous immunoglobulin for the treatment of severe sepsis and septic shock in critically ill adults: A systematic review and meta-analysis*
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  139. PHILLIPS CR , Chesnutt MS, Smith SM
    Extravascular lung water in sepsis-associated acute respiratory distress syndrome: Indexing with predicted body weight improves correlation with severity of illness and survival*
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  140. FIDAN H , Sahin O, Yavuz Y, Kilbas A, et al
    Caffeic acid phenethyl ester reduces mortality and sepsis-induced lung injury in rats*
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  141. BATEMAN RM , Sharpe MD, Goldman D, Lidington D, et al
    Inhibiting nitric oxide overproduction during hypotensive sepsis increases local oxygen consumption in rat skeletal muscle*
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  142. BELIKOVA I , Lukaszewicz AC, Ass VF, Damoisel C, et al
    Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis*
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  143. SAKR Y , Vincent JL, De Backer D
    Does red blood cell transfusion result in a variate microvascular response in sepsis?
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  144. TANG BM , Huang SJ, Seppelt I, McLean AS, et al
    Predictive value of N-terminal pro-brain natriuretic peptide in sepsis.
    Crit Care Med. 2007;35:2464.
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  145. DEN UIL CA , Lagrand WK, Spronk PE, Simoons ML, et al
    Does red blood cell transfusion result in a variate microvascular response in sepsis?
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  146. DELLINGER RP , Schorr C
    Severe sepsis in an emergency department: Prevalence, rapid identification, and appropriate treatment.
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  147. LEVY B , Lacolley P, Regnault V
    ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin) and endothelial dysfunction in sepsis: Marker or culprit?
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  148. BOWLER R , Reisdorph N
    Mining the liver proteome for drug targets for sepsis.
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  149. LOMAS-NEIRA JL , Ayala A
    CXCL2 polymorphism in sepsis and acute respiratory distress syndrome: Pathological significance lost in translation.
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  150. ABRAHAM E , Singer M
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  151. HOTTA N , Ichiyama T, Shiraishi M, Takekawa T, et al
    Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis.
    Crit Care Med. 2007;35:2395-401.
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  152. MARTIN K , Borgel D, Lerolle N, Feys HB, et al
    Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure.
    Crit Care Med. 2007;35:2375-82.
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  153. KIANK C , Koerner P, Kessler W, Traeger T, et al
    Seasonal variations in inflammatory responses to sepsis and stress in mice.
    Crit Care Med. 2007;35:2352-8.
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  154. BARRETT LK , Orie NN, Taylor V, Stidwill RP, et al
    Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis.
    Crit Care Med. 2007;35:2337-43.
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  155. DEAR JW , Leelahavanichkul A, Aponte A, Hu X, et al
    Liver proteomics for therapeutic drug discovery: inhibition of the cyclophilin receptor CD147 attenuates sepsis-induced acute renal failure.
    Crit Care Med. 2007;35:2319-28.
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  156. VILLAR J , Perez-Mendez L, Flores C, Maca-Meyer N, et al
    A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis.
    Crit Care Med. 2007;35:2292-7.
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  157. MORIMATSU H
    Stewart has come to the bedside: is it time to use the Stewart methodology routinely?
    Crit Care Med. 2007;35:2456-7.
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  158. VAN WESTERLOO DJ
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  159. MORELLI A , Ertmer C, Westphal M
    Ten years of vasopressin research in septic shock: constant dripping wears the stone.
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  160. LORENTE L , Jimenez A, Santana M, Iribarren JL, et al
    Microorganisms responsible for intravascular catheter-related bloodstream infection according to the catheter site.
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    September 2007
  161. HUSTON JM , Puerta MG, Ochani M, Ochani K, et al
    Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis*
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  162. CHENG B , Xie G, Yao S, Wu X, et al
    Epidemiology of severe sepsis in critically ill surgical patients in ten university hospitals in China*
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  163. HOPKINS RO
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  164. SPRAY DC , Tanowitz HB
    Pathology of mechanical and gap junctional co-coupling at the intercalated disc: Is sepsis a junctionopathy?
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  165. ANDERSON RJ
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  166. TRZECIAK S , De Backer D
    Modulation of the sepsis inflammatory response by resuscitation: The missing link between cytopathic and hypoxic hypoxia?
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  167. BARICHELLO T , Machado RA, Constantino L, Valvassori SS, et al
    Antioxidant treatment prevented late memory impairment in an animal model of sepsis.
    Crit Care Med. 2007;35:2186-90.
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  168. CELES MR , Torres-Duenas D, Alves-Filho JC, Duarte DB, et al
    Reduction of gap and adherens junction proteins and intercalated disc structural remodeling in the hearts of mice submitted to severe cecal ligation and puncture sepsis.
    Crit Care Med. 2007;35:2176-85.
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  169. SCHMIDT C , Hocherl K, Schweda F, Bucher M, et al
    Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis.
    Crit Care Med. 2007;35:2110-9.
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  170. HUANG DT , Clermont G, Dremsizov TT, Angus DC, et al
    Implementation of early goal-directed therapy for severe sepsis and septic shock: A decision analysis.
    Crit Care Med. 2007;35:2090-100.
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  171. RIVERS EP , Kruse JA, Jacobsen G, Shah K, et al
    The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock.
    Crit Care Med. 2007;35:2016-24.
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  172. HSIEH YC , Frink M, Choudhry MA, Bland KI, et al
    Metabolic modulators following trauma sepsis: sex hormones.
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  173. NORBURY WB , Jeschke MG, Herndon DN
    Metabolism modulators in sepsis: propranolol.
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  174. MAXIME V , Siami S, Annane D
    Metabolism modulators in sepsis: the abnormal pituitary response.
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  175. BIOLO G , Antonione R, De Cicco M
    Glutathione metabolism in sepsis.
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  176. BERGER MM , Chiolero RL
    Antioxidant supplementation in sepsis and systemic inflammatory response syndrome.
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  177. BARBUL A , Uliyargoli A
    Use of exogenous arginine in multiple organ dysfunction syndrome and sepsis.
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  178. LUIKING YC , Deutz NE
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  179. TAPPY L , Chiolero R
    Substrate utilization in sepsis and multiple organ failure.
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  180. LEVY RJ , Deutschman CS
    Cytochrome c oxidase dysfunction in sepsis.
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  181. FREDRIKSSON K , Rooyackers O
    Mitochondrial function in sepsis: respiratory versus leg muscle.
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  182. SINGER M
    Mitochondrial function in sepsis: acute phase versus multiple organ failure.
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  183. VINCENT JL
    Metabolic support in sepsis and multiple organ failure: more questions than answers ...
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  184. HERNDON DN , Wernerman J
    Metabolic support in sepsis and multiple organ failure.
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  185. PROTTI A , Carre J, Frost MT, Taylor V, et al
    Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle.
    Crit Care Med. 2007;35:2150-5.
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  186. PIEL DA , Gruber PJ, Weinheimer CJ, Courtois MR, et al
    Mitochondrial resuscitation with exogenous cytochrome c in the septic heart.
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  187. DE JONGHE B , Bastuji-Garin S, Durand MC, Malissin I, et al
    Respiratory weakness is associated with limb weakness and delayed weaning in critical illness.
    Crit Care Med. 2007;35:2007-15.
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  188. WHEELER DS
    Understanding the role of stress proteins in acute lung injury: Closer to the answer, but not there yet.
    Crit Care Med. 2007;35:2226-7.
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  189. FINK MP
    Administration of exogenous cytochrome c as a novel approach for the treatment of cytopathic hypoxia.
    Crit Care Med. 2007;35:2224-5.
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  190. SCHULTZ MJ , Spronk PE
    Positive blood cultures or Gram-negative pathogens with ventilator-associated pneumonia: What's the real killer?
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  191. AGBAHT K , Diaz E, Munoz E, Lisboa T, et al
    Bacteremia in patients with ventilator-associated pneumonia is associated with increased mortality: A study comparing bacteremic vs. nonbacteremic ventilator-associated pneumonia.
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  192. Metabolic support in sepsis and multiple organ failure. Proceedings of a roundtable conference. March 24-26, 2007. Brussels, Belgium.
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  193. RUSSELL JA
    Vasopressin in septic shock.
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  194. BIESALSKI HK , McGregor GP
    Antioxidant therapy in critical care--is the microcirculation the primary target?
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  195. TJADER I , Berg A, Wernerman J
    Exogenous glutamine--compensating a shortage?
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  196. BONGERS T , Griffiths RD, McArdle A
    Exogenous glutamine: the clinical evidence.
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  197. YASUHARA S , Asai A, Sahani ND, Martyn JA, et al
    Mitochondria, endoplasmic reticulum, and alternative pathways of cell death in critical illness.
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  198. LEVERVE XM
    Mitochondrial function and substrate availability.
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    August 2007
  199. O'DELL E , Tibby SM, Durward A, Murdoch IA, et al
    Hyperchloremia is the dominant cause of metabolic acidosis in the postresuscitation phase of pediatric meningococcal sepsis*
    Crit Care Med. 2007;.
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  200. CARLBOM DJ , Rubenfeld GD
    Barriers to implementing protocol-based sepsis resuscitation in the emergency department-Results of a national survey*
    Crit Care Med. 2007;Publish Ahead of Print.
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  201. DEAR JW , Leelahavanichkul A, Aponte A, Hu X, et al
    Liver proteomics for therapeutic drug discovery: Inhibition of the cyclophilin receptor CD147 attenuates sepsis-induced acute renal failure*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  202. HOTTA N , Ichiyama T, Shiraishi M, Takekawa T, et al
    Nuclear factor-kappaB activation in peripheral blood mononuclear cells in children with sepsis*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  203. VILLAR J , Perez-Mendez L, Flores C, Maca-Meyer N, et al
    A CXCL2 polymorphism is associated with better outcomes in patients with severe sepsis*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  204. BARRETT LK , Orie NN, Taylor V, Stidwill RP, et al
    Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  205. ABRAHAM E , Singer M
    Mechanisms of sepsis-induced organ dysfunction.
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  206. KIANK C , Koerner P, Keler W, Traeger T, et al
    Seasonal variations in inflammatory responses to sepsis and stress in mice*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  207. MARTIN K , Borgel D, Lerolle N, Feys HB, et al
    Decreased a disintegrin-like and metalloprotease with thrombospondin (ADAMTS)-13 is associated with a poor prognosis in sepsis-induced organ failure*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  208. LUYER M , Greve JW, de Haan J, Lubbers T, et al
    Are we finally taming inflammation?
    Crit Care Med. 2007;35:2003-4.
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  209. GAFFIN SL
    A pathophysiology-based approach to care of nuclear explosion victims.
    Crit Care Med. 2007;35:1998.
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  210. KNOEBL PN
    Is there an association between hemostatic abnormalities and the outcome of acute lung injury?
    Crit Care Med. 2007;35:1980-2.
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  211. GARNACHO-MONTERO J , Sa-Borges M, Sole-Violan J, Barcenilla F, et al
    Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia: an observational, multicenter study comparing monotherapy with combination antibiotic therapy.
    Crit Care Med. 2007;35:1888-95.
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  212. MONNERET G , Voirin N, Krawice-Radanne I, Bohe J, et al
    Soluble human leukocyte antigen-G5 in septic shock: marked and persisting elevation as a predictor of survival.
    Crit Care Med. 2007;35:1942-7.
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  213. VENET F , Tissot S, Debard AL, Faudot C, et al
    Decreased monocyte human leukocyte antigen-DR expression after severe burn injury: Correlation with severity and secondary septic shock.
    Crit Care Med. 2007;35:1910-7.
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  214. DE JONG MF , Beishuizen A, Spijkstra JJ, Groeneveld AB, et al
    Relative adrenal insufficiency as a predictor of disease severity, mortality, and beneficial effects of corticosteroid treatment in septic shock.
    Crit Care Med. 2007;35:1896-903.
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  215. SCHALLER G , Pleiner J, Mittermayer F, Posch M, et al
    Effects of N-acetylcysteine against systemic and renal hemodynamic effects of endotoxin in healthy humans.
    Crit Care Med. 2007;35:1869-75.
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    July 2007
  216. RIVERS EP , Kruse JA, Jacobsen G, Shah K, et al
    The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  217. SCHMIDT C , Hocherl K, Schweda F, Bucher M, et al
    Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  218. BARICHELLO T , Machado RA, Constantino L, Valvassori SS, et al
    Antioxidant treatment prevented late memory impairment in an animal model of sepsis*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  219. CELES MR , Torres-Duenas D, Alves-Filho JC, Duarte DB, et al
    Reduction of gap and adherens junction proteins and intercalated disc structural remodeling in the hearts of mice submitted to severe cecal ligation and puncture sepsis*
    Crit Care Med. 2007;Publish Ahead of Print.
    PubMed     Related articles    Abstract available


  220. HUANG DT , Clermont G, Dremsizov TT, Angus DC, et al
    Implementation of early goal-directed therapy for severe sepsis and septic shock: A decision analysis.
    Crit Care Med. 2007;Publish Ahead of Print.
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  221. MCLEAN AS , Huang SJ
    Prognostic value of natriuretic peptides in severe sepsis.
    Crit Care Med. 2007;35:1806.
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  222. BRUECKMANN M , Hoffmann U
    Prognostic value of natriuretic peptides in severe sepsis.
    Crit Care Med. 2007;35:1805-6.
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  223. FU SL , Bluth MH
    Monitoring efficacy of red blood cell transfusion in sepsis by sublingual microvascular perfusion: A tongue speaks without words.
    Crit Care Med. 2007;35:1773-4.
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  224. CHO SJ , Kanna B
    Selenium in intensive care: An interesting yet not fully proven concept.
    Crit Care Med. 2007;35:1812.
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  225. ALLEVA LM
    Biologically active versus immunoreactive high-mobility group box 1.
    Crit Care Med. 2007;35:1809.
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  226. CHAN LN
    Selenium supplementation in septic patients: the method of delivery matters.
    Crit Care Med. 2007;35:1802-3.
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  227. ERTMER C , Westphal M, Bone HG
    Norepinephrine in septic shock--does the early bird catch the worm?
    Crit Care Med. 2007;35:1794-5.