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Articles published in Crit Care

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    January 2005
  1. MORGAN ET
    A Role for One or More P450 Enzymes in the Response to Sepsis.
    Crit Care Med 2005;33:268-269.
    PubMed     Related articles   


  2. SORIANO FG
    Quality of life: Late sequela in sepsis.
    Crit Care Med 2005;33:262.
    PubMed     Related articles   


  3. TSCHOEKE SK , Moldawer LL
    Human leukocyte antigen expression in sepsis: What have we learned?
    Crit Care Med 2005;33:236.
    PubMed     Related articles   


  4. CARROL ED , Newland P, Thomson AP, Hart CA, et al
    Prognostic value of procalcitonin in children with meningococcal sepsis.
    Crit Care Med 2005;33:224-225.
    PubMed     Related articles    Abstract available


  5. BARICHELLO T , Martins MR, Reinke A, Feier G, et al
    Cognitive impairment in sepsis survivors from cecal ligation and perforation.
    Crit Care Med 2005;33:221-223.
    PubMed     Related articles    Abstract available


  6. XIAO H , Remick DG
    Correction of perioperative hypothermia decreases experimental sepsis mortality by modulating the inflammatory response.
    Crit Care Med 2005;33:161-167.
    PubMed     Related articles    Abstract available


  7. SUNDARARAJAN V , Macisaac CM, Presneill JJ, Cade JF, et al
    Epidemiology of sepsis in Victoria, Australia.
    Crit Care Med 2005;33:71-80.
    PubMed     Related articles    Abstract available


    December 2004
  8. STEINSTRAESSER L
    Sepsis-New strategies with host defense peptides?
    Crit Care Med 2004;32:2555-6.
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  9. DEANS KJ , Minneci PC, Banks SM, Natanson C, et al
    Substantiating the concerns about recombinant human activated protein C use in sepsis.
    Crit Care Med 2004;32:2542-3.
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  10. STUBBE HD , Traber DL, Booke M, Traber LD, et al
    Role of atrial natriuretic peptide in pulmonary permeability and vasoregulation in ovine sepsis.
    Crit Care Med 2004;32:2491-2495.
    PubMed     Related articles    Abstract available


  11. GIACOMETTI A , Cirioni O, Ghiselli R, Bergnach C, et al
    The antimicrobial peptide BMAP-28 reduces lethality in mouse models of staphylococcal sepsis.
    Crit Care Med 2004;32:2485-2490.
    PubMed     Related articles    Abstract available


  12. MACIAS WL , Vallet B, Bernard GR, Vincent JL, et al
    Sources of variability on the estimate of treatment effect in the PROWESS trial: Implications for the design and conduct of future studies in severe sepsis.
    Crit Care Med 2004;32:2385-2391.
    PubMed     Related articles    Abstract available


  13. ALEXANDER SL , Lilly E, Angus DC, Barnato AE, et al
    Racial variation in the incidence, ICU utilization, and mortality of severe sepsis: 35.
    Crit Care Med 2004;32.
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  14. JEAN WHITE D , Sanders B, Horton JW
    Selective decontamination of the digestive tract (sdd) attenuates postburn myocardial contractile depression associated with post-burn sepsis: 13.
    Crit Care Med 2004;32.
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  15. RUSSELL JA , Shaw DM, Sutherland AM, Walley KR, et al
    An interaction of novel haplotypes of protein C and endothelial protein C receptor is associated with decreased survival and increased organ dysfunction in sirs and sepsis: 72.
    Crit Care Med 2004;32.
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  16. WU R , Dong W, Zhou M, Cui X, et al
    Mechanism of the improvement of organ perfusion by ghrelin in severe sepsis: downregulation of endothelin-1: 65.
    Crit Care Med 2004;32.
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  17. DIPASCO PJ , Chang KC, Davis CG, Unsinger J, et al
    CD40 LIGAND PROTECTS AGAINST SEPSIS INDUCED B-CELL APOPTOSIS: 62.
    Crit Care Med 2004;32:A16.
    PubMed     Related articles   


  18. ZANOTTI-CAVAZZONI SL , Goldfarb RD, Dellinger RP, Ortegel J, et al
    A CYTOKINE PRODUCTION INHIBITOR (TAK-242) IMPROVES CARDIOVASCULAR PERFORMANCE, INHIBITS CYTOKINE RELEASE AND INCREASES SURVIVAL IN A PORCINE MODEL OF GRAM-NEGATIVE SEPSIS: 59.
    Crit Care Med 2004;32:A15.
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  19. MACIAS WL , Nelson DR
    Minor changes in renal function are highly predictive of outcome in severe sepsis patients from the indepth integrated database: 45.
    Crit Care Med 2004;32.
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  20. NAKADA TA , Hirasawa H, Oda S, Watanabe E, et al
    Not toll-like receptor 4 nor cd14 gene polymorphisms but tumor necrosis factor and inter-leukine-10 gene polymorphisms have influence on clinical outcome of sepsis: 47.
    Crit Care Med 2004;32.
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  21. NGUYEN HB , Corbett SW, Cho T, Garcia M, et al
    Improving the uniformity of care with the stop sepsis bundle: strategies to timely obviate the progression of sepsis in the emergency department: 44.
    Crit Care Med 2004;32.
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  22. OSTROSKY-ZEICHNER L
    Prophylaxis or preemptive therapy of invasive candidiasis in the intensive care unit?
    Crit Care Med 2004;32:2552-3.
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  23. PIARROUX R , Grenouillet F, Balvay P, Tran V, et al
    Assessment of preemptive treatment to prevent severe candidiasis in critically ill surgical patients.
    Crit Care Med 2004;32:2443-9.
    PubMed     Related articles    Abstract available


    November 2004
  24. LEVY MM , Pronovost PJ, Dellinger RP, Townsend S, et al
    Sepsis change bundles: Converting guidelines into meaningful change in behavior and clinical outcome.
    Crit Care Med 2004;32:S595-S597.
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  25. GEA-BANACLOCHE JC , Opal SM, Jorgensen J, Carcillo JA, et al
    Sepsis associated with immunosuppressive medications: An evidence-based review.
    Crit Care Med 2004;32:S578-S590.
    PubMed     Related articles    Abstract available


  26. TRZECIAK S , Dellinger RP
    Other supportive therapies in sepsis: An evidence-based review.
    Crit Care Med 2004;32:S571-7.
    PubMed     Related articles    Abstract available


  27. CARIOU A , Vinsonneau C, Dhainaut JF
    Adjunctive therapies in sepsis: An evidence-based review.
    Crit Care Med 2004;32:S562-70.
    PubMed     Related articles    Abstract available


  28. VENDER JS , Szokol JW, Murphy GS, Nitsun M, et al
    Sedation, analgesia, and neuromuscular blockade in sepsis: An evidence-based review.
    Crit Care Med 2004;32:S554-61.
    PubMed     Related articles    Abstract available


  29. SEVRANSKY JE , Levy MM, Marini JJ
    Mechanical ventilation in sepsis-induced acute lung injury/acute respiratory distress syndrome: An evidence-based review.
    Crit Care Med 2004;32:S548-S553.
    PubMed     Related articles    Abstract available


  30. ZIMMERMAN JL
    Use of blood products in sepsis: An evidence-based review.
    Crit Care Med 2004;32:S542-7.
    PubMed     Related articles    Abstract available


  31. FOURRIER F
    Recombinant human activated protein C in the treatment of severe sepsis: An evidence-based review.
    Crit Care Med 2004;32:S534-41.
    PubMed     Related articles    Abstract available


  32. KEH D , Sprung CL
    Use of corticosteroid therapy in patients with sepsis and septic shock: An evidence-based review.
    Crit Care Med 2004;32:S527-3.
    PubMed     Related articles    Abstract available


  33. MARSHALL JC , Maier RV, Jimenez M, Dellinger EP, et al
    Source control in the management of severe sepsis and septic shock: An evidence-based review.
    Crit Care Med 2004;32:S513-26.
    PubMed     Related articles    Abstract available


  34. BOCHUD PY , Bonten M, Marchetti O, Calandra T, et al
    Antimicrobial therapy for patients with severe sepsis and septic shock: An evidence-based review.
    Crit Care Med 2004;32:S495-S512.
    PubMed     Related articles    Abstract available


  35. COHEN J , Brun-Buisson C, Torres A, Jorgensen J, et al
    Diagnosis of infection in sepsis: An evidence-based review.
    Crit Care Med 2004;32:S466-S494.
    PubMed     Related articles    Abstract available


  36. VINCENT JL , Gerlach H
    Fluid resuscitation in severe sepsis and septic shock: An evidence-based review.
    Crit Care Med 2004;32:S451-4.
    PubMed     Related articles    Abstract available


  37. PARKER MM , Hazelzet JA, Carcillo JA
    Pediatric considerations.
    Crit Care Med 2004;32.
    PubMed     Related articles    Abstract available


  38. BEALE RJ , Hollenberg SM, Vincent JL, Parrillo JE, et al
    Vasopressor and inotropic support in septic shock: an evidence-based review.
    Crit Care Med 2004;32.
    PubMed     Related articles    Abstract available


  39. RHODES A , Bennett ED
    Early goal-directed therapy: an evidence-based review.
    Crit Care Med 2004;32.
    PubMed     Related articles    Abstract available


  40. GRASS G , Neugebauer EA
    Afelimomab-Another therapeutic option in sepsis therapy?
    Crit Care Med 2004;32:2343-4.
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  41. OSBORN TM , Tracy JK, Dunne JR, Pasquale M, et al
    Epidemiology of sepsis in patients with traumatic injury.
    Crit Care Med 2004;32:2234-2240.
    PubMed     Related articles    Abstract available


  42. LATERRE PF , Levy H, Clermont G, Ball DE, et al
    Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial.
    Crit Care Med 2004;32:2207-2218.
    PubMed     Related articles    Abstract available


  43. ANGUS DC , Laterre PF, Helterbrand J, Ely EW, et al
    The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis.
    Crit Care Med 2004;32:2199-2206.
    PubMed     Related articles    Abstract available


  44. PANACEK EA , Marshall JC, Albertson TE, Johnson DH, et al
    Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels.
    Crit Care Med 2004;32:2173-2182.
    PubMed     Related articles    Abstract available


    October 2004
  45. SHEFFIELD JS
    Sepsis and septic shock in pregnancy.
    Crit Care Clin 2004;20:651-60.
    PubMed     Related articles    Abstract available


  46. LUIKING YC , Poeze M, Dejong CH, Ramsay G, et al
    Sepsis: An arginine deficiency state?
    Crit Care Med 2004;32:2135-45.
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  47. KEPROS JP , Hassan M
    No argument for not accepting a single, well-performed trial for the highest level of recommendation.
    Crit Care Med 2004;32:2167.
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  48. ZANDSTRA DF , van der Voort PH
    A more appropriate critical appraisal of the available evidence?
    Crit Care Med 2004;32:2166-7.
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  49. BUCHMAN TG
    In vivo, in vitro, in silico...
    Crit Care Med 2004;32:2159-60.
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  50. MARSHALL JC
    Through a glass darkly: the brave new world of in silico modeling.
    Crit Care Med 2004;32:2157-9.
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  51. NASRAWAY SA JR
    Eliminating catheter-related bloodstream infections: fairy tale or new reality?
    Crit Care Med 2004;32:2150-2.
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  52. CLERMONT G , Bartels J, Kumar R, Constantine G, et al
    In silico design of clinical trials: a method coming of age.
    Crit Care Med 2004;32:2061-70.
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  53. AN G
    In silico experiments of existing and hypothetical cytokine-directed clinical trials using agent-based modeling.
    Crit Care Med 2004;32:2050-60.
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    September 2004
  54. MANTZ J , Paugam-Burtz C
    Hypothermia, sepsis, and the granulocytes: Lessons to learn beyond the cytokines.
    Crit Care Med 2004;32:1974-5.
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  55. DAL-PIZZOL F
    Alternative activated macrophage: A new key for systemic inflammatory response syndrome and sepsis treatment?
    Crit Care Med 2004;32:1971-2.
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  56. WIEDERMANN CJ
    Improvement in coagulation markers with antithrombin- Beneficial in severe sepsis?
    Crit Care Med 2004;32:1968-9.
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  57. HOLLENBERG SM , Ahrens TS, Annane D, Astiz ME, et al
    Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update.
    Crit Care Med 2004;32:1928-48.
    PubMed     Related articles    Abstract available


  58. MOSS RF , Parmar NK, Tighe D, Davies DC, et al
    Adrenergic agents modify cerebral edema and microvessel ultrastructure in porcine sepsis.
    Crit Care Med 2004;32:1916-1921.
    PubMed     Related articles    Abstract available


  59. HOFFMANN JN , Muhlbayer D, Jochum M, Inthorn D, et al
    Effect of long-term and high-dose antithrombin supplementation on coagulation and fibrinolysis in patients with severe sepsis.
    Crit Care Med 2004;32:1851-1859.
    PubMed     Related articles    Abstract available


  60. MARIK PE
    Adrenal insufficiency: the link between low apolipoprotein A-I levels and poor outcome in the critically ill?
    Crit Care Med 2004;32:1977-8.
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  61. HOLMES CL
    Is low-dose vasopressin the new reno-protective agent?
    Crit Care Med 2004;32:1972-4.
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  62. INCE C
    Microcirculation in distress: a new resuscitation end point?
    Crit Care Med 2004;32:1963-4.
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  63. KIRSCHENBAUM LA , McKevitt D, Rullan M, Reisbeck B, et al
    Importance of platelets and fibrinogen in neutrophil-endothelial cell interactions in septic shock.
    Crit Care Med 2004;32:1904-9.
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  64. TOROSSIAN A , Ruehlmann S, Middeke M, Sessler DI, et al
    Mild preseptic hypothermia is detrimental in rats.
    Crit Care Med 2004;32:1899-903.
    PubMed     Related articles    Abstract available


  65. ALBERT M , Losser MR, Hayon D, Faivre V, et al
    Systemic and renal macro- and microcirculatory responses to arginine vasopressin in endotoxic rabbits.
    Crit Care Med 2004;32:1891-8.
    PubMed     Related articles    Abstract available


  66. TAKAHASHI H , Tsuda Y, Takeuchi D, Kobayashi M, et al
    Influence of systemic inflammatory response syndrome on host resistance against bacterial infections.
    Crit Care Med 2004;32:1879-85.
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  67. SAKR Y , Dubois MJ, De Backer D, Creteur J, et al
    Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock.
    Crit Care Med 2004;32:1825-31.
    PubMed     Related articles    Abstract available


    August 2004
  68. YOUNG GB
    Programmed neuronal death in sepsis: Caught in a crossfire or a planned sacrifice?
    Crit Care Med 2004;32:1804-5.
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  69. MESSARIS E , Memos N, Chatzigianni E, Konstadoulakis MM, et al
    Time-dependent mitochondrial-mediated programmed neuronal cell death prolongs survival in sepsis.
    Crit Care Med 2004;32:1764-1770.
    PubMed     Related articles    Abstract available


  70. WU R , Cui X, Lim YP, Bendelja K, et al
    Delayed administration of human inter-alpha inhibitor proteins reduces mortality in sepsis.
    Crit Care Med 2004;32:1747-1752.
    PubMed     Related articles    Abstract available



  71. Open randomized phase II trial of an extracorporeal endotoxin adsorber in suspected Gram-negative sepsis.
    Crit Care Med 2004;32:1662-1668.
    PubMed     Related articles    Abstract available


  72. NGUYEN HB , Rivers EP, Knoblich BP, Jacobsen G, et al
    Early lactate clearance is associated with improved outcome in severe sepsis and septic shock.
    Crit Care Med 2004;32:1637-1642.
    PubMed     Related articles    Abstract available


  73. RUSSWURM S , Reinhart K
    Procalcitonin mode of action: new pieces in a complex puzzle.
    Crit Care Med 2004;32:1801-2.
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  74. GRASS G , Neugebauer EA
    Extracorporeal endotoxin adsorption in septic patients--does it work?
    Crit Care Med 2004;32:1792-3.
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  75. TRZECIAK S
    Lac-time?
    Crit Care Med 2004;32:1785-6.
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  76. SAKODA M , Ueno S, Kihara K, Arikawa K, et al
    A potential role of hyperbaric oxygen exposure through intestinal nuclear factor-kappaB.
    Crit Care Med 2004;32:1722-9.
    PubMed     Related articles    Abstract available


  77. LINSCHEID P , Seboek D, Schaer DJ, Zulewski H, et al
    Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes.
    Crit Care Med 2004;32:1715-21.
    PubMed     Related articles    Abstract available


  78. JONES AE , Tayal VS, Sullivan DM, Kline JA, et al
    Randomized, controlled trial of immediate versus delayed goal-directed ultrasound to identify the cause of nontraumatic hypotension in emergency department patients.
    Crit Care Med 2004;32:1703-8.
    PubMed     Related articles    Abstract available


    July 2004
  79. DELLINGER RP , Carlet J, Gerlach H, Keh D, et al
    Central Venous and Mixed Venous Oxygen Saturations in the Surviving Sepsis Campaign Guidelines: The authors reply.
    Crit Care Med 2004;32:1627-8.
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  80. STEFANEC T
    Central venous and mixed venous oxygen saturations in the surviving sepsis campaign guidelines.
    Crit Care Med 2004;32:1626-7.
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  81. STALLONE JN
    Predicting mortality from sepsis: Is protein C a true crystal ball?
    Crit Care Med 2004;32:1620-1.
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  82. TIMSIT JF
    Sepsis: Let's go back to the infectious process.
    Crit Care Med 2004;32:1616-1617.
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  83. SAYEED MM
    Delay of neutrophil apoptosis can exacerbate inflammation in sepsis patients: Cellular mechanisms.
    Crit Care Med 2004;32:1604-6.
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  84. DELLINGER RP , Carlet JM, Gerlach H, Ramsey G, et al
    The Surviving Sepsis Guidelines: Not another "Groundhog Day".
    Crit Care Med 2004;32:1601-2.
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  85. LANDUCCI D
    The surviving sepsis guidelines: "Lost in translation".
    Crit Care Med 2004;32:1598-600.
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  86. HEUER JG , Sharma GR, Gerlitz B, Zhang T, et al
    Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis.
    Crit Care Med 2004;32:1570-8.
    PubMed     Related articles    Abstract available


  87. TANEJA R , Parodo J, Jia SH, Kapus A, et al
    Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity.
    Crit Care Med 2004;32:1460-1469.
    PubMed     Related articles    Abstract available


  88. DEPRIEST JL
    Stress ulcer prophylaxis.
    Crit Care Med 2004;32:1626.
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  89. RENES MH , van der Hoeven JG
    Administration of nitric oxide synthase inhibitor 546C88 in septic shock.
    Crit Care Med 2004;32:1625.
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  90. COHEN J , Cristofaro P, Carlet J, Opal S, et al
    New method of classifying infections in critically ill patients.
    Crit Care Med 2004;32:1510-26.
    PubMed     Related articles    Abstract available


    June 2004
  91. HAUSER B , Radermacher P, Albuszies G
    Antioxidants and Sepsis: Can We Find the Ideal Approach?: The authors reply.
    Crit Care Med 2004;32:1446.
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  92. RITTER C , Andrades M, Moreira JC, Dal-Pizzol F, et al
    Antioxidants and sepsis: can we find the ideal approach?
    Crit Care Med 2004;32:1445-6.
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  93. WESTPHAL M , Bone HG
    Are vasodilatory shock states due to sepsis and cardiovascular surgery like two peas in a pod?
    Crit Care Med 2004;32:1411-1412.
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  94. MARIK P
    Does the age of blood matter?
    Crit Care Med 2004;32:1442-3.
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  95. BAUE AE
    Let's be splitters, rather than "lumpers".
    Crit Care Med 2004;32:1440.
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  96. DUNSER MW , Hasibeder WR, Wenzel V, Mayr AJ, et al
    Lessons learned from high-dosage vasopressin infusion in septic shock.
    Crit Care Med 2004;32:1433-4.
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  97. HOLMES CL
    Vasopressin in septic shock: does dose matter?
    Crit Care Med 2004;32:1423-4.
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  98. GENOVESE T , Di Paola R, Catalano P, Li JH, et al
    Treatment with a novel poly(ADP-ribose) glycohydrolase inhibitor reduces development of septic shock-like syndrome induced by zymosan in mice.
    Crit Care Med 2004;32:1365-74.
    PubMed     Related articles    Abstract available


  99. MALAY MB , Ashton JL, Dahl K, Savage EB, et al
    Heterogeneity of the vasoconstrictor effect of vasopressin in septic shock.
    Crit Care Med 2004;32:1327-31.
    PubMed     Related articles    Abstract available


  100. TANIGUCHI T , Kidani Y, Kanakura H, Takemoto Y, et al
    Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats.
    Crit Care Med 2004;32:1322-6.
    PubMed     Related articles    Abstract available


  101. STRAUSS R , Neureiter D, Westenburger B, Wehler M, et al
    Multifactorial risk analysis of bone marrow histiocytic hyperplasia with hemophagocytosis in critically ill medical patients--a postmortem clinicopathologic analysis.
    Crit Care Med 2004;32:1316-21.
    PubMed     Related articles    Abstract available


  102. SCHWEICKERT WD , Gehlbach BK, Pohlman AS, Hall JB, et al
    Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients.
    Crit Care Med 2004;32:1272-6.
    PubMed     Related articles    Abstract available


    May 2004
  103. TEXEREAU J , Pene F, Chiche JD, Rousseau C, et al
    Importance of hemostatic gene polymorphisms for susceptibility to and outcome of severe sepsis.
    Crit Care Med 2004;32:S313-9.
    PubMed     Related articles    Abstract available


  104. LEVI M , Choi G, Schoots I, Schultz M, et al
    Beyond sepsis: Activated protein C and ischemia-reperfusion injury.
    Crit Care Med 2004;32:S309-12.
    PubMed     Related articles    Abstract available


  105. PAWLINSKI R , Mackman N
    Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis.
    Crit Care Med 2004;32:S293-7.
    PubMed     Related articles    Abstract available


  106. JOYCE DE , Nelson DR, Grinnell BW
    Leukocyte and endothelial cell interactions in sepsis: Relevance of the protein C pathway.
    Crit Care Med 2004;32:S280-6.
    PubMed     Related articles    Abstract available


  107. YAN SB , Nelson DR
    Effect of factor V Leiden polymorphism in severe sepsis and on treatment with recombinant human activated protein C.
    Crit Care Med 2004;32:S239-S246.
    PubMed     Related articles    Abstract available


  108. WEILER H , Kerlin B, Lytle MC
    Factor V Leiden polymorphism modifies sepsis outcome: Evidence from animal studies.
    Crit Care Med 2004;32:S233-8.
    PubMed     Related articles    Abstract available


  109. MACIAS WL , Nelson DR
    Severe protein C deficiency predicts early death in severe sepsis.
    Crit Care Med 2004;32:S223-8.
    PubMed     Related articles    Abstract available


  110. ESMON CT
    Why do animal models (sometimes) fail to mimic human sepsis?
    Crit Care Med 2004;32:S219-S222.
    PubMed     Related articles    Abstract available


  111. LIAW PC
    Endogenous protein C activation in patients with severe sepsis.
    Crit Care Med 2004;32:S214-8.
    PubMed     Related articles    Abstract available


  112. VINCENT JL
    Endpoints in sepsis trials: More than just 28-day mortality?
    Crit Care Med 2004;32:S209-13.
    PubMed     Related articles    Abstract available


  113. DHAINAUT JF , Yan SB, Claessens YE
    Protein C/activated protein C pathway: Overview of clinical trial results in severe sepsis.
    Crit Care Med 2004;32:S194-201.
    PubMed     Related articles    Abstract available


  114. REINHART K , Gluck T, Ligtenberg J, Tschaikowsky K, et al
    CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14).
    Crit Care Med 2004;32:1100-8.
    PubMed     Related articles    Abstract available


  115. GROESDONK HV , Senftleben U
    Modulation of inhibitor kappaB kinase/ nuclear factor kappaB signaling during critical illness: a double-edged sword.
    Crit Care Med 2004;32:1239.
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  116. BAR-OR D , Kepros JP
    Anemia associated with critical illness: is the erythropoietin receptor a culprit?
    Crit Care Med 2004;32:1234-5.
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  117. KING LS , Rabb H
    Muscling in on systemic inflammatory response syndrome.
    Crit Care Med 2004;32:1233-4.
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  118. FINNEY SJ , Evans TW
    Glucose and the immune system: a victory for Claude Bernard?
    Crit Care Med 2004;32:1224-5.
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  119. GIBOT S
    Fighting the enemy properly?
    Crit Care Med 2004;32:1223-4.
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  120. KONRAD D , Oldner A, Rossi P, Wanecek M, et al
    Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock.
    Crit Care Med 2004;32:1192-9.
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  121. CUI X , Wu R, Zhou M, Simms HH, et al
    Differential expression of cytochrome P450 isoforms in the lungs of septic animals.
    Crit Care Med 2004;32:1186-91.
    PubMed     Related articles    Abstract available


  122. JAVADI P , Buchman TG, Stromberg PE, Husain KD, et al
    High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis.
    Crit Care Med 2004;32:1178-85.
    PubMed     Related articles    Abstract available


  123. ADEMBRI C , Kastamoniti E, Bertolozzi L, Vanni S, et al
    Pulmonary injury follows systemic inflammatory reaction in infrarenal aortic surgery.
    Crit Care Med 2004;32:1170-7.
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  124. CLEC'H C , Ferriere F, Karoubi P, Fosse JP, et al
    Diagnostic and prognostic value of procalcitonin in patients with septic shock.
    Crit Care Med 2004;32:1166-9.
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  125. QUASNEY MW , Waterer GW, Dahmer MK, Kron GK, et al
    Association between surfactant protein B + 1580 polymorphism and the risk of respiratory failure in adults with community-acquired pneumonia.
    Crit Care Med 2004;32:1115-9.
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  126. RUF W
    Protease-activated receptor signaling in the regulation of inflammation.
    Crit Care Med 2004;32.
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  127. AIRD WC
    Endothelium as an organ system.
    Crit Care Med 2004;32.
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    April 2004
  128. MAKI DG
    Microbiologic diagnosis of blood culture-negative sepsis by hemofiltration.
    Crit Care Med 2004;32:1075-7.
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  129. ZAKYNTHINOS SG , Papanikolaou S, Theodoridis T, Zakynthinos EG, et al
    Sepsis severity is the major determinant of circulating thrombopoietin levels in septic patients.
    Crit Care Med 2004;32:1004-1010.
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  130. LEE H , Doig CJ, Ghali WA, Donaldson C, et al
    Detailed cost analysis of care for survivors of severe sepsis.
    Crit Care Med 2004;32:981-985.
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  131. BAUE AE
    When will we learn?
    Crit Care Med 2004;32:1093.
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  132. VAN DER POLL T , Levi M
    Mechanisms of action of activated protein C: an evolving story.
    Crit Care Med 2004;32:1086-7.
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  133. CORONA A , Raimondi F, Singer M
    Severe bloodstream infections from the community: risk factors and outcomes.
    Crit Care Med 2004;32:1083-4.
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  134. GORBUNOV NV , McFaul SJ, Van Albert S, Morrissette C, et al
    Assessment of inflammatory response and sequestration of blood iron transferrin complexes in a rat model of lung injury resulting from exposure to low-frequency shock waves.
    Crit Care Med 2004;32:1028-34.
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  135. BERCAULT N , Boulain T, Kuteifan K, Wolf M, et al
    Obesity-related excess mortality rate in an adult intensive care unit: A risk-adjusted matched cohort study.
    Crit Care Med 2004;32:998-1003.
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  136. LAUPLAND KB , Gregson DB, Zygun DA, Doig CJ, et al
    Severe bloodstream infections: a population-based assessment.
    Crit Care Med 2004;32:992-7.
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  137. IOANAS M , Ferrer M, Cavalcanti M, Ferrer R, et al
    Causes and predictors of nonresponse to treatment of intensive care unit-acquired pneumonia.
    Crit Care Med 2004;32:938-945.
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  138. HANSARD PC , Haseeb MA, Manning RA, Salwen MJ, et al
    Recovery of bacteria by continuous renal replacement therapy in septic shock and by ultrafiltration from an in vitro model of bacteremia.
    Crit Care Med 2004;32:932-7.
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    March 2004
  139. HOTCHKISS RS , Karl IE
    Endothelial cell apoptosis in sepsis: a case of habeas corpus?
    Crit Care Med 2004;32:901-2.
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  140. HONORE PM , Matson JR
    Extracorporeal removal for sepsis: Acting at the tissue level--the beginning of a new era for this treatment modality in septic shock.
    Crit Care Med 2004;32:896-7.
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  141. SHORR AF
    Polishing the crystal ball: Improving our understanding of survival in sepsis.
    Crit Care Med 2004;32:885-6.
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  142. DELLINGER RP , Carlet JM, Masur H, Gerlach H, et al
    Surviving sepsis campaign guidelines for management of severe sepsis and septic shock.
    Crit Care Med 2004;32:858-73.
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  143. KASAL J , Jovanovic Z, Clermont G, Weissfeld LA, et al
    Comparison of Cox and Gray's survival models in severe sepsis.
    Crit Care Med 2004;32:700-7.
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  144. CHARPENTIER J , Luyt CE, Fulla Y, Vinsonneau C, et al
    Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis.
    Crit Care Med 2004;32:660-5.
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  145. ASSADIAN O
    Skin antiseptic in reducing the risk of central venous catheter-related infections.
    Crit Care Med 2004;32:887-8.
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  146. GORDON BR
    Poor outcomes associated with low lipid and lipoprotein levels.
    Crit Care Med 2004;32:878-9.
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  147. CRNICH CJ , Proctor RA
    Treatment of pneumococcal pneumonia: what's in an MIC?
    Crit Care Med 2004;32:876-8.
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  148. OPAL SM
    Unintended bias, clinical trial results, and the heparin post hoc crossover fallacy.
    Crit Care Med 2004;32:874-5.
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  149. CLAASSEN J , Vu A, Kreiter KT, Kowalski RG, et al
    Effect of acute physiologic derangements on outcome after subarachnoid hemorrhage.
    Crit Care Med 2004;32:832-8.
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  150. JANISZEWSKI M , Do Carmo AO, Pedro MA, Silva E, et al
    Platelet-derived exosomes of septic individuals possess proapoptotic NAD(P)H oxidase activity: A novel vascular redox pathway.
    Crit Care Med 2004;32:818-25.
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  151. KELLUM JA , Song M, Venkataraman R
    Hemoadsorption removes tumor necrosis factor, interleukin-6, and interleukin-10, reduces nuclear factor-kappaB DNA binding, and improves short-term survival in lethal endotoxemia.
    Crit Care Med 2004;32:801-5.
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  152. CHUANG CC , Hung CJ, Tsai MC, Yeh TM, et al
    High concentrations of circulating macrophage migration inhibitory factor in patients with severe blunt trauma: Is serum macrophage migration inhibitory factor concentration a valuable prognostic factor?
    Crit Care Med 2004;32:734-9.
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  153. CHENAUD C , Merlani PG, Roux-Lombard P, Burger D, et al
    Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation.
    Crit Care Med 2004;32:632-7.
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  154. LUJAN M , Gallego M, Fontanals D, Mariscal D, et al
    Prospective observational study of bacteremic pneumococcal pneumonia: Effect of discordant therapy on mortality.
    Crit Care Med 2004;32:625-31.
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    February 2004
  155. YAN SB , Dhainaut JF, Schwarz HP, Ehrlich HJ, et al
    Only activated protein C treatment and not protein C has demonstrated an improvement in survival in severe sepsis.
    Crit Care Med 2004;32:618-9.
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  156. BAYARDELLE P , Albertson TE, MacArthur RD
    Antibody to enterobacterial common antigen and gram-negative sepsis.
    Crit Care Med 2004;32:617-8.
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  157. ZINGARELLI B
    Peptidoglycan is an important pathogenic factor of the inflammatory response in sepsis.
    Crit Care Med 2004;32:613-4.
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  158. FINK MP
    Peroxisome proliferator-activated receptor-gamma ligands: A pluripotent class of pharmacological agents that may prove to be useful for adjuvant treatment of sepsis and multiple organ dysfunction syndrome.
    Crit Care Med 2004;32:604-5.
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  159. CROUSER ED
    Therapeutic benefits of antioxidants during sepsis: Is protection against oxidant-mediated tissue damage only half the story?
    Crit Care Med 2004;32:589-90.
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  160. LIN MT , Albertson TE
    Genomic polymorphisms in sepsis.
    Crit Care Med 2004;32:569-79.
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  161. DEMPFLE CE , Lorenz S, Smolinski M, Wurst M, et al
    Utility of activated partial thromboplastin time waveform analysis for identification of sepsis and overt disseminated intravascular coagulation in patients admitted to a surgical intensive care unit.
    Crit Care Med 2004;32:520-4.
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  162. CRAWFORD JH , Yang S, Zhou M, Simms HH, et al
    Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis.
    Crit Care Med 2004;32:502-8.
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  163. DOERSCHUG KC , Powers LS, Monick MM, Thorne PS, et al
    Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsis.
    Crit Care Med 2004;32:489-94.
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  164. RITTER C , Andrades ME, Reinke A, Menna-Barreto S, et al
    Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis.
    Crit Care Med 2004;32:342-9.
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  165. OPAL S , Laterre PF, Abraham E, Francois B, et al
    Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial.
    Crit Care Med 2004;32:332-41.
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  166. LEHMANN C , Pavlovic D, Usichenko TI
    Sphingomyelinase pathway activation in septic myocardial depression--another brick in the wall?
    Crit Care Med 2004;32:609-10.
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  167. AUBOYER C , Bouletreau P
    Risk of bloodstream infection can be strongly decreased by a very moderate caloric intake or strongly increased by a very low caloric intake in severely ill patients in intensive care?
    Crit Care Med 2004;32:591-2.
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  168. MINNECI PC , Deans KJ, Banks SM, Eichacker PQ, et al
    Should we continue to target the platelet-activating factor pathway in septic patients?
    Crit Care Med 2004;32:585-8.
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  169. BJERRE A , Brusletto B, Hoiby EA, Kierulf P, et al
    Plasma interferon-gamma and interleukin-10 concentrations in systemic meningococcal disease compared with severe systemic Gram-positive septic shock.
    Crit Care Med 2004;32:433-8.
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  170. RUBINSON L , Diette GB, Song X, Brower RG, et al
    Low caloric intake is associated with nosocomial bloodstream infections in patients in the medical intensive care unit.
    Crit Care Med 2004;32:350-7.
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    January 2004
  171. PRAVINKUMAR E, Dellinger RP
    Cardiovascular management of septic shock.
    Crit Care Med 2004; 32: 315.
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  172. RIVERS EP , Nguyen HB, Huang DT, Donnino M, et al
    Early goal-directed therapy.
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  173. VERDANT CL , Dubois MJ
    Normality.
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  174. BENOIT DD , Depuydt P, Vandewoude KH
    Bacterial infection.
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  175. TAIBERG L , Kumar A
    Leukocyte lysozyme: a novel cause of septic myocardial depression?
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  176. NAPOLITANO LM
    Optimization of intestinal mucosal oxygenation in shock: a role for medical therapy?
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  177. GOODELL KH , Jordan MR, Graham R, Cassidy C, et al
    Rapidly advancing necrotizing fasciitis caused by Photobacterium (Vibrio) damsela: a hyperaggressive variant.
    Crit Care Med 2004;32:278-81.
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  178. WESTPHAL M , Freise H, Kehrel BE, Bone HG, et al
    Arginine vasopressin compromises gut mucosal microcirculation in septic rats.
    Crit Care Med 2004;32:194-200.
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  179. KNUEPFER MM , Bloodgood TA, Matuschak GM, Lechner AJ, et al
    Cocaine enhances susceptibility to endotoxemic shock in a subset of rats.
    Crit Care Med 2004;32:175-83.
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  180. LOPEZ A , Lorente JA, Steingrub J, Bakker J, et al
    Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock.
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  181. WATSON D, Grover R, Anzueto A, Lorente J, Smithies M, Bellomo R et al
    Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: Results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).
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  182. PHILLIP DELLINGER R, Parrillo JE
    Mediator modulation therapy of severe sepsis and septic shock: Does it work?
    Crit Care Med 2004; 32: 282-6.
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  183. MINK SN, Jacobs H, Duke K, Bose D, Cheng ZQ, Light RB
    N,N’,N’-triacetylglucosamine, an inhibitor of lysozyme, prevents myocardial depression in Escherichia co
    Crit Care Med 2004; 32: 184-93.
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  184. BAKKER J, Grover R, McLuckie A, Holzapfel L, Andersson J, Lodato R et al
    Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: Results of no. 144-002).
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  185. BERENHOLTZ SM , Pronovost PJ, Lipsett PA, Hobson D, et al
    Eliminating catheter-related bloodstream infections in the intensive care unit.
    Crit Care Med 2004;32:2014-2020.
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    December 2003
  186. RELLO J, Rodriguez A
    Improving survival for sepsis: on the cutting edge.
    Crit Care Med 2003; 31: 2807-8.
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  187. GARNACHO-MONTERO J, Garcia-Garmendia JL, Barrero-Almodovar A, Jimenez-Jimenez FJ, Perez-Paredes C, Ortiz-Leyba C
    Impact of adequate empirical antibiotic therapy on the outcome of patients admitted to the intensive care unit with sepsis.
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  188. YU DT, Platt R, Lanken PN, Black E, Sands KE, Schwartz JS et al
    Relationship of pulmonary artery catheter use to mortality and resource utilization in patients with severe sepsis.
    Crit Care Med 2003; 31: 2734-41.
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    November 2003
  189. PINSKY MR
    Antioxidant therapy for severe sepsis: Promise and perspective.
    Crit Care Med 2003; 31: 2697-8.
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  190. CLERMONT G, Angus DC, Kalassian KG, Linde-Zwirble WT, Ramakrishnan N, Linden PK et al
    Reassessing the value of short-term mortality in sepsis: Comparing conventional approaches to modeling.
    Crit Care Med 2003; 31: 2627-33.
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  191. PATERSON RL, Galley HF, Webster NR
    The effect of N-acetylcysteine on nuclear factor-kappaB activation, interleukin-6, interleukin-8, and intercellular adhesion molecule-1 expression in patients with sepsis.
    Crit Care Med 2003; 31: 2574-8.
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  192. RUSSELL JA
    Vasopressin in septic shock: clinical equipoise mandates a time for restraint.
    Crit Care Med 2003; 31: 2707-9.
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  193. KLINZING S, Simon M, Reinhart K, Bredle DL, Meier-Hellmann A
    High-dose vasopressin is not superior to norepinephrine in septic shock.
    Crit Care Med 2003; 31: 2646-50.
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  194. MASUDA Y, Sumita S, Fujimura N, Namiki A
    Geranylgeranylacetone attenuates septic diaphragm dysfunction by induction of heat shock protein 70.
    Crit Care Med 2003; 31: 2585-91.
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  195. PERES BOTA D, Melot C, Lopes Ferreira F, Vincent JL
    Infection Probability Score (IPS): A method to help assess the probability of infection in critically ill patients.
    Crit Care Med 2003; 31: 2579-84.
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    October 2003
  196. CARLET J
    Drotrecogin alfa (activated) administration: too many subgroups.
    Crit Care Med 2003; 31: 2564
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  197. DI GIANTOMASSO D, Morimatsu H, May CN, Bellomo R
    Intrarenal blood flow distribution in hyperdynamic septic shock: Effect of norepinephrine.
    Crit Care Med 2003; 31: 2509-13.
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  198. HUMES HD, Buffington DA, Lou L, Abrishami S, Wang M, Xia J et al
    Cell therapy with a tissue-engineered kidney reduces the multiple-organ consequences of septic shock.
    Crit Care Med 2003; 31: 2421-8.
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    September 2003
  199. FINK MP
    Nuclear factor-kappaB: is it a therapeutic target for the adjuvant treatment of sepsis?
    Crit Care Med 2003; 31: 2400-2.
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  200. PADKIN A, Goldfrad C, Brady AR, Young D, Black N, Rowan K
    Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland.
    Crit Care Med 2003; 31: 2332-8.
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  201. WEYCKER D, Akhras KS, Edelsberg J, Angus DC, Oster G
    Long-term mortality and medical care charges in patients with severe sepsis.
    Crit Care Med 2003; 31: 2316-23.
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  202. DHAINAUT JF, Laterre PF, LaRosa SP, Levy H, Garber GE, Heiselman D et al
    The clinical evaluation committee in a large multicenter phase 3 trial of drotrecogin alfa (activated) in patients with severe sepsis (PROWESS): role, methodology, and results.
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  203. SHEEHAN M, Wong HR, Hake PW, Zingarelli B
    Parthenolide improves systemic hemodynamics and decreases tissue leukosequestration in rats with polymicrobial sepsis.
    Crit Care Med 2003; 31: 2263-70.
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  204. TSITANIDIS J
    Cost-effectiveness of drotrecogin alfa (activated).
    Crit Care Med 2003; 31: 2414-5
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  205. TEPLICK R
    Clinical evaluation committees: the time is right but is the timing right?
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  206. DEZFULIAN C, Lavelle J, Nallamothu BK, Kaufman SR, Saint S
    Rates of infection for single-lumen versus multilumen central venous catheters: a meta-analysis.
    Crit Care Med 2003; 31: 2385-90.
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    August 2003
  207. JOORE JC, Van Leeuwen HJ, Meulenbelt J, Tobe TJ, Figen JW
    Pro/Con debate of activated protein C in severe sepsis.
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  208. REMICK DG, Bolgos GE, Siddiqui J
    Inflammatory status in sepsis alters efficacy of interleukin-18 binding protein therapy.
    Crit Care Med 2003; 31: 2096-101.
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  209. BENTREM DJ, Joehl RJ
    Pancreas: healing response in critical illness.
    Crit Care Med 2003; 31: S582-9.
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  210. AYALA A, Chung CS, Grutkoski PS, Song GY
    Mechanisms of immune resolution.
    Crit Care Med 2003; 31: S558-71.
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  211. HOPF HW
    Molecular diagnostics of injury and repair responses in critical illness: What is the future of "monitoring" in the intensive care unit?
    Crit Care Med 2003; 31: S518-23.
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  212. SHIPMAN J, Guy J, Abumrad NN
    Repair of metabolic processes.
    Crit Care Med 2003; 31: S512-7.
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  213. FESSLER MB, O’Brien JM, Douglas IS
    Laboratory predictors of relative adrenal insufficiency in septic shock.
    Crit Care Med 2003; 31: 2251-2
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  214. ANNANE D, Briegel J, Keh D, Moreno R, Singer M, Sprung CL
    Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone.
    Crit Care Med 2003; 31: 2250-1
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  215. EFRON PA, Moldawer LL
    Blocking interleukin-18: a tumor necrosis factor-alpha lesson already learned.
    Crit Care Med 2003; 31: 2241-2.
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  216. GRAF J, Koch M, Dujardin R, Kersten A, Janssens U
    Health-related quality of life before, 1 month after, and 9 months after intensive care in medical cardiovascular and pulmonary patients.
    Crit Care Med 2003; 31: 2163-9.
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  217. PIAGNERELLI M, Boudjeltia KZ, Brohee D, Piro P, Carlier E, Vincent JL et al
    Alterations of red blood cell shape and sialic acid membrane content in septic patients.
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  218. TAMION F, Richard V, Sauger F, Menard JF, Girault C, Richard JC et al
    Gastric mucosal acidosis and cytokine release in patients with septic shock.
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    July 2003
  219. NIMAH M, Brilli RJ
    Coagulation dysfunction in sepsis and multiple organ system failure.
    Crit Care Clin 2003; 19: 441-58.
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  220. SHANLEY TP, Wong HR
    Molecular genetics in the pediatric intensive care unit.
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  221. CARCILLO JA
    Pediatric septic shock and multiple organ failure.
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  222. ALSTON TA
    Nuclear fallout in sepsis.
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  223. MONNERET G, Debard AL, Venet F, Bohe J, Hequet O, Bienvenu J et al
    Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis.
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  224. BECK GCH, Hermes WC, Yard BA, Kaszkin M, Von Zabern D, Schulte J et al
    Amelioration of endotoxin-induced sepsis in rats by membrane anchored lipid conjugates.
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  225. ZEERLEDER S, Zwart B, Wuillemin WA, Aarden LA, Groeneveld MD AB, Caliezi MD C et al
    Elevated nucleosome levels in systemic inflammation and sepsis.
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  226. ZISER A, Strickland RA, Murray MJ
    Propofol does not induce pulmonary dysfunction in stressed endotoxic pigs receiving Intralipid.
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  227. WARREN DK, Zack JE, Cox MJ, Cohen MM, Fraser VJ
    An educational intervention to prevent catheter-associated bloodstream infections in a nonteaching, community medical center.
    Crit Care Med 2003; 31: 1959-63.
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  228. JACOBS S, Price Evans DA, Tariq M, Al Omar NF
    Fluconazole improves survival in septic shock: a randomized double-blind prospective study.
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    June 2003
  229. COOK JA
    The Toll of sepsis: Altered innate immunity in polymicrobial sepsis.
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  230. CUHACI B
    Plasma exchange in multiple organ failure: Changing gears in sepsis and organ failure.
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  231. SAYEED MM
    Intestinal epithelial regenerative capacity: An "Achilles’ heel" in trauma/burn/sepsis injuries?
    Crit Care Med 2003; 31: 1864-6.
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  232. RABINOVICI R
    Platelet activating factor inhibition in sepsis: The end?
    Crit Care Med 2003; 31: 1861-2.
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  233. DE KLEIJN ED, De Groot R, Hack CE, H Mulder PG, Engl W, Moritz B et al
    Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study.
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  234. WILLIAMS DL, Ha T, Li C, Kalbfleisch JH, Schweitzer J, Vogt W et al
    Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality.
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  235. LUZZANI A, Polati E, Dorizzi R, Rungatscher A, Pavan R, Merlini A
    Comparison of procalcitonin and C-reactive protein as markers of sepsis.
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  236. PETERS DL, Barber RC, Flood EM, Garner HR, O’Keefe GE
    Methodologic quality and genotyping reproducibility in studies of tumor necrosis factor -308 G-->A single nucleotide polymorphism and bacterial sepsis: Implications for studies of complex traits.
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  237. MANGLIK S, Flores E, Lubarsky L, Fernandez F, Chhibber VL, Tayek JA
    Glucocorticoid insufficiency in patients who present to the hospital with severe sepsis: A prospective clinical trial.
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  238. COOPERSMITH CM, Stromberg PE, Davis CG, Dunne WM, Amiot DM 2nd, Karl IE et al
    Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest.
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  239. SCHUSTER DP, Metzler M, Opal S, Lowry S, Balk R, Abraham E et al
    Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial.
    Crit Care Med 2003; 31: 1612-9.
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  240. STUBER F
    Genomics and critical care: do the right thing!
    Crit Care Med 2003; 31: 1869-70.
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  241. ANNANE D
    Time for a consensus definition of corticosteroid insufficiency in critically ill patients.
    Crit Care Med 2003; 31: 1868-9.
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  242. LEVY B
    Epinephrine in septic shock: Dr. Jekyll or Mr. Hyde?
    Crit Care Med 2003; 31: 1866-7.
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  243. CHAI J, Wu Y, Sheng ZZ
    Role of ubiquitin-proteasome pathway in skeletal muscle wasting in rats with endotoxemia.
    Crit Care Med 2003; 31: 1802-7.
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  244. MUTSCHLER DK, Eriksson MB, Wikstrom BG, Lind L, Larsson A, Bergren-Kiiski R et al
    Microdialysis-evaluated myocardial cyclooxygenase-mediated inflammation and early circulatory depression in porcine endotoxemia.
    Crit Care Med 2003; 31: 1780-5.
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  245. SHARSHAR T, Blanchard A, Paillard M, Raphael JC, Gajdos P, Annane D
    Circulating vasopressin levels in septic shock.
    Crit Care Med 2003; 31: 1752-8.
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  246. STEGMAYR BG, Banga R, Berggren L, Norda R, Rydvall A, Vikerfors T
    Plasma exchange as rescue therapy in multiple organ failure including acute renal failure.
    Crit Care Med 2003; 31: 1730-6.
    PubMed     Related articles    Abstract available


  247. SPOLARICS Z, Siddiqi M, Siegel JH, Garcia ZC, Stein DS, Denny T et al
    Depressed interleukin-12-producing activity by monocytes correlates with adverse clinical course and a shift toward Th2-type lymphocyte pattern in severely injured male trauma patients.
    Crit Care Med 2003; 31: 1722-9.
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  248. DOBBINS BM, Catton JA, Kite P, McMahon MJ, Wilcox MH
    Each lumen is a potential source of central venous catheter-related bloodstream infection.
    Crit Care Med 2003; 31: 1688-90.
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  249. DE BACKER D, Creteur J, Silva E, Vincent JL
    Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?
    Crit Care Med 2003; 31: 1659-67.
    PubMed     Related articles    Abstract available


  250. LEVELS JH, Lemaire LC, van den Ende AE, van Deventer SJ, van Lanschot JJ
    Lipid composition and lipopolysaccharide binding capacity of lipoproteins in plasma and lymph of patients with systemic inflammatory response syndrome and multiple organ failure.
    Crit Care Med 2003; 31: 1647-53.
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    May 2003
  251. MARSHALL JC, Vincent JL, Fink MP, Cook DJ, Rubenfeld G, Foster D et al
    Measures, markers, and mediators: toward a staging system for clinical sepsis. A report of the Fifth Toronto Sepsis Roundtable, Toronto, Ontario, Canada, October 25-26, 2000.
    Crit Care Med 2003; 31: 1560-7.
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  252. PALLUA N, Low JF, Von Heimburg D
    Pathogenic role of interleukin-6 in the development of sepsis. Part II: Significance of anti-interleukin-6 and anti-soluble interleukin-6 receptor-alpha antibodies in a standardized murine contact burn model.
    Crit Care Med 2003; 31: 1495-501.
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  253. PALLUA N, von Heimburg D
    Pathogenic role of interleukin-6 in the development of sepsis. Part I: Study in a standardized contact burn murine model.
    Crit Care Med 2003; 31: 1490-4.
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  254. MARX C, Petros S, Bornstein SR, Weise M, Wendt M, Menschikowski M et al
    Adrenocortical hormones in survivors and nonsurvivors of severe sepsis: Diverse time course of dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol.
    Crit Care Med 2003; 31: 1382-8.
    PubMed     Related articles    Abstract available


  255. VAN LEEUWEN HJ, Heezius EC, Dallinga GM, Van Strijp JA, Verhoef J, Van Kessel KP
    Lipoprotein metabolism in patients with severe sepsis.
    Crit Care Med 2003; 31: 1359-66.
    PubMed     Related articles    Abstract available


  256. CARROLL GC
    Which came first?
    Crit Care Med 2003; 31: 1603.
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  257. EVGENOV OV, Bjertnaes LJ
    Administration of methylene blue in human septic shock: renaissance of an old drug?
    Crit Care Med 2003; 31: 1601-2
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  258. SCHWARZ HP, Ehrlich HJ
    Activated protein C: more effective than nonactivated protein C?
    Crit Care Med 2003; 31: 1597.
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  259. MCGEE WT, Tereso GJ
    Successful treatment of Candida krusei infection with caspofungin acetate: a new antifungal agent.
    Crit Care Med 2003; 31: 1577-8.
    PubMed     Related articles    Abstract available


  260. LAW WR, Valli VE, Conlon BA
    Therapeutic potential for transient inhibition of adenosine deaminase in systemic inflammatory response syndrome.
    Crit Care Med 2003; 31: 1475-81.
    PubMed     Related articles    Abstract available


  261. LIN CY, Zhang H, Cheng KC, Slutsky AS
    Mechanical ventilation may increase susceptibility to the development of bacteremia.
    Crit Care Med 2003; 31: 1429-34.
    PubMed     Related articles    Abstract available


  262. WATERER GW, ElBahlawan L, Quasney MW, Zhang Q, Kessler LA, Wunderink RG
    Heat shock protein 70-2+1267 AA homozygotes have an increased risk of septic shock in adults with community-acquired pneumonia.
    Crit Care Med 2003; 31: 1367-72.
    PubMed     Related articles    Abstract available


  263. CHEN YY, Yen DH, Yang YG, Liu CY, Wang FD, Chou P
    Comparison between replacement at 4 days and 7 days of the infection rate for pulmonary artery catheters in an intensive care unit.
    Crit Care Med 2003; 31: 1353-8.
    PubMed     Related articles    Abstract available


  264. LEON C, Alvarez-Lerma F, Ruiz-Santana S, Gonzalez V, de la Torre MV, Sierra R et al
    Antiseptic chamber-containing hub reduces central venous catheter-related infection: a prospective, randomized study.
    Crit Care Med 2003; 31: 1318-24.
    PubMed     Related articles    Abstract available


  265. PINSKY MR
    Genetic testing: Costs and access to intensive care unit care.
    Crit Care Med 2003; 31: S411-5.
    PubMed     Related articles    Abstract available


    April 2003
  266. CAIN BS, Shannon-Cain J
    Cardiopulmonary bypass: homemade sepsis?
    Crit Care Med 2003; 31: 1281-2.
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  267. LEVY MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D et al
    2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference.
    Crit Care Med 2003; 31: 1250-6.
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  268. BERG S, Sappington PL, Guzik LJ, Delude RL, Fink MP
    Proinflammatory cytokines increase the rate of glycolysis and adenosine-5’-triphosphate turnover in cultured rat enterocytes.
    Crit Care Med 2003; 31: 1203-12.
    PubMed     Related articles    Abstract available


  269. BENO DW, Uhing MR, Goto M, Chen Y, Jiyamapa-Serna VA, Kimura RE
    Chronic Staphylococcal enterotoxin B and lipopolysaccharide induce a bimodal pattern of hepatic dysfunction and injury.
    Crit Care Med 2003; 31: 1154-9.
    PubMed     Related articles    Abstract available


  270. LEHMANN C, Birnbaum J, Grundling M
    Chronic exposure to multiple bacterial toxins--enough is as good as a feast.
    Crit Care Med 2003; 31: 1285-6.
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  271. ROGIERS P, Zhang H, Pauwels D, Vincent JL
    Comparison of polyacrylonitrile (AN69) and polysulphone membrane during hemofiltration in canine endotoxic shock.
    Crit Care Med 2003; 31: 1219-25.
    PubMed     Related articles    Abstract available


  272. KILGER E, Weis F, Briegel J, Frey L, Goetz AE, Reuter D et al
    Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery.
    Crit Care Med 2003; 31: 1068-74.
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  273. DIXON B, Santamaria JD, Campbell DJ
    Plasminogen activator inhibitor activity is associated with raised lactate levels after cardiac surgery with cardiopulmonary bypass.
    Crit Care Med 2003; 31: 1053-9.
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  274. MOTOYAMA T, Okamoto K, Kukita I, Hamaguchi M, Kinoshita Y, Ogawa H
    Possible role of increased oxidant stress in multiple organ failure after systemic inflammatory response syndrome.
    Crit Care Med 2003; 31: 1048-52.
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    March 2003
  275. ALSTON TA
    Sepsis and hypovolemia: Two bad.
    Crit Care Med 2003; 31: 991-2.
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  276. MARIK PE
    Cardiovascular dysfunction of sepsis: A nitric oxide- and l-arginine-deficient state?
    Crit Care Med 2003; 31: 971-3.
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  277. RIVERS EP, Nguyen HB, Amponsah D
    Sepsis: A landscape from the emergency department to the intensive care unit.
    Crit Care Med 2003; 31: 968-9.
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  278. POSCHL JM, Leray C, Ruef P, Cazenave JP, Linderkamp O
    Endotoxin binding to erythrocyte membrane and erythrocyte deformability in human sepsis and in vitro.
    Crit Care Med 2003; 31: 924-928.
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  279. FUJII H, Takahashi T, Nakahira K, Uehara K, Shimizu H, Matsumi M et al
    Protective role of heme oxygenase-1 in the intestinal tissue injury in an experimental model of sepsis.
    Crit Care Med 2003; 31: 893-902.
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  280. ABRAHAM E, Naum C, Bandi V, Gervich D, Lowry SF, Wunderink R et al
    Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure.
    Crit Care Med 2003; 31: 718-28.
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  281. SHAPIRO NI, Wolfe RE, Moore RB, Smith E, Burdick E, Bates DW
    Mortality in Emergency Department Sepsis (MEDS) score: A prospectively derived and validated clinical prediction rule.
    Crit Care Med 2003; 31: 670-5.
    PubMed     Related articles    Abstract available


  282. DOUZINAS EE
    The hepatosplanchnic area is not a common source of lactate production.
    Crit Care Med 2003; 31: 999
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  283. LEVI M
    Benefit of recombinant human activated protein C beyond 28-day mortality: there is more to life than death.
    Crit Care Med 2003; 31: 984-5.
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  284. DELLINGER RP
    Cardiovascular management of septic shock.
    Crit Care Med 2003; 31: 946-55.
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  285. OPAL SM, Palardy JE, Parejo N, Jasman RL
    Effect of anti-CD14 monoclonal antibody on clearance of Escherichia coli bacteremia and endotoxemia.
    Crit Care Med 2003; 31: 929-32.
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  286. LOUGHREY JP, Laffey JG, Moore BJ, Lynch F, Boylan JF, McLoughlin P
    Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism.
    Crit Care Med 2003; 31: 910-5.
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  287. HINDER F, Stubbe HD, Van Aken H, Baba HA, Jahn UR, Brodner G et al
    Early multiple organ failure after recurrent endotoxemia in the presence of vasoconstrictor-masked hypovolemia.
    Crit Care Med 2003; 31: 903-9.
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  288. MOSS M, Parsons PE, Steinberg KP, Hudson LD, Guidot DM, Burnham EL et al
    Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock.
    Crit Care Med 2003; 31: 869-77.
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  289. BRAUSE M, Neumann A, Schumacher T, Grabensee B, Heering P
    Effect of filtration volume of continuous venovenous hemofiltration in the treatment of patients with acute renal failure in intensive care units.
    Crit Care Med 2003; 31: 841-6.
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  290. VINCENT JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH et al
    Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial.
    Crit Care Med 2003; 31: 834-40.
    PubMed     Related articles    Abstract available


  291. MARIK PE, Bankov A
    Sublingual capnometry versus traditional markers of tissue oxygenation in critically ill patients.
    Crit Care Med 2003; 31: 818-22.
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  292. TUGRUL S, Akinci O, Ozcan PE, Ince S, Esen F, Telci L et al
    Effects of sustained inflation and postinflation positive end-expiratory pressure in acute respiratory distress syndrome: focusing on pulmonary and extrapulmonary forms.
    Crit Care Med 2003; 31: 738-44.
    PubMed     Related articles    Abstract available


  293. LEVRAUT J, Ichai C, Petit I, Ciebiera JP, Perus O, Grimaud D
    Low exogenous lactate clearance as an early predictor of mortality in normolactatemic critically ill septic patients.
    Crit Care Med 2003; 31: 705-10.
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  294. SIBELIUS U, Grandel U, Buerke M, Kiss L, Klingenberger P, Heep M et al
    Leukotriene-mediated coronary vasoconstriction and loss of myocardial contractility evoked by low doses of Escherichia coli hemolysin in perfused rat hearts.
    Crit Care Med 2003; 31: 683-8.
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    February 2003
  295. CARCILLO JA
    Does arginine become a "near" essential amino acid during sepsis?
    Crit Care Med 2003; 31: 657-9.
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  296. ALVERDY JC, Laughlin RS, Wu L
    Influence of the critically ill state on host-pathogen interactions within the intestine: Gut-derived sepsis redefined.
    Crit Care Med 2003; 31: 598-607.
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  297. ALBERTSON TE, Panacek EA, MacArthur RD, Johnson SB, Benjamin E, Matuschak GM et al
    Multicenter evaluation of a human monoclonal antibody to Entero-bacteriaceae common antigen in patients with Gram-negative sepsis.
    Crit Care Med 2003; 31: 419-27.
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  298. HUGONNET S, Harbarth S, Ferriere K, Ricou B, Suter P, Pittet D
    Bacteremic sepsis in intensive care: Temporal trends in incidence, organ dysfunction, and prognosis.
    Crit Care Med 2003; 31: 390-4.
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  299. ROOT RK, Lodato RF, Patrick W, Cade JF, Fotheringham N, Milwee S et al
    Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis.
    Crit Care Med 2003; 31: 367-373.
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  300. KARAM GH, Niederman MS
    How do we achieve adequate therapy for severe infection?
    Crit Care Med 2003; 31: 648-50.
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  301. KUMAR A, Wood K, Parrillo JE
    Circulating substances and energy metabolism in septic shock.
    Crit Care Med 2003; 31: 632-3.
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  302. ARGAMAN Z, Young VR, Noviski N, Castillo-Rosas L, Lu XM, Zurakowski D et al
    Arginine and nitric oxide metabolism in critically ill septic pediatric patients.
    Crit Care Med 2003; 31: 591-7.
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  303. LEONE M, Bourgoin A, Cambon S, Dubuc M, Albanese J, Martin C
    Empirical antimicrobial therapy of septic shock patients: adequacy and impact on the outcome.
    Crit Care Med 2003; 31: 462-7.
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  304. BOULOS M, Astiz ME, Barua RS, Osman M
    Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase.
    Crit Care Med 2003; 31: 353-8.
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    January 2003
  305. OLIVER JA, Landry DW
    Patient with a sudden drop in blood pressure.
    Crit Care Med 2003; 31: 326-7.
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  306. KENYON N
    Defining adrenal insufficiency in septic shock.
    Crit Care Med 2003; 31: 321-3.
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  307. BANKS SM, Gerstenberger E, Eichacker PQ, Natanson C
    Long-term cost effectiveness of drotrecogin alfa (activated): an unanswered question.
    Crit Care Med 2003; 31: 308-9.
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  308. CHALFIN DB, Teres D, Rapoport J
    A price for cost-effectiveness: implications for recombinant human activated protein C (rhAPC).
    Crit Care Med 2003; 31: 306-8.
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  309. MACARTHUR H, Couri DM, Wilken GH, Westfall TC, Lechner AJ, Matuschak GM et al
    Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholamines.
    Crit Care Med 2003; 31: 237-45.
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  310. TRENTZSCH H, Stewart D, De Maio A
    Genetic background conditions the effect of sex steroids on the inflammatory response during endotoxic shock.
    Crit Care Med 2003; 31: 232-6.
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  311. ASFAR P, Pierrot M, Veal N, Moal F, Oberti F, Croquet V et al
    Low-dose terlipressin improves systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats.
    Crit Care Med 2003; 31: 215-20.
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  312. HEESEN M, Kunz D, Bachmann-Mennenga B, Merk HF, Bloemeke B
    Linkage disequilibrium between tumor necrosis factor (TNF)-alpha-308 G/A promoter and TNF-beta NcoI polymorphisms: Association with TNF-alpha response of granulocytes to endotoxin stimulation.
    Crit Care Med 2003; 31: 211-4.
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  313. KREJCI V, Hiltebrand LB, Erni D, Sigurdsson GH
    Endothelin receptor antagonist bosentan improves microcirculatory blood flow in splanchnic organs in septic shock.
    Crit Care Med 2003; 31: 203-10.
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  314. WALLEY KR, McDonald TE, Wang Y, Dai S, Russell JA
    Albumin resuscitation increases cardiomyocyte contractility and decreases nitric oxide synthase II expression in rat endotoxemia.
    Crit Care Med 2003; 31: 187-94.
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  315. FENWICK P, Ryan C, Sriskandan S, Cohen J
    Application of a rat model of streptococcal shock to evaluate on-line hemoperfusion and removal of circulating superantigens.
    Crit Care Med 2003; 31: 171-8.
    PubMed     Related articles    Abstract available


  316. MARIK PE, Zaloga GP
    Adrenal insufficiency during septic shock.
    Crit Care Med 2003; 31: 141-5.
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  317. BENOIT DD, Vandewoude KH, Decruyenaere JM, Hoste EA, Colardyn FA
    Outcome and early prognostic indicators in patients with a hematologic malignancy admitted to the intensive care unit for a life-threatening complication.
    Crit Care Med 2003; 31: 104-12.
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  318. SCHRODER O, Schulte KM, Ostermann P, Roher HD, Ekkernkamp A, Laun RA
    Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury.
    Crit Care Med 2003; 31: 73-9.
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  319. RANUCCI M, Isgro G, Giomarelli PP, Pavesi M, Luzzani A, Cattabriga I et al
    Impact of oligon central venous catheters on catheter colonization and catheter-related bloodstream infection.
    Crit Care Med 2003; 31: 52-9.
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  320. LOWE PR, Galley HF, Abdel-Fattah A, Webster NR
    Influence of interleukin-10 polymorphisms on interleukin-10 expression and survival in critically ill patients.
    Crit Care Med 2003; 31: 34-8.
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  321. ZINGARELLI B, Sheehan M, Wong HR
    Nuclear factor-kappaB as a therapeutic target in critical care medicine.
    Crit Care Med 2003; 31: S105-11.
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  322. BHOLE D, Stahl GL
    Therapeutic potential of targeting the complement cascade in critical care medicine.
    Crit Care Med 2003; 31: S97-104.
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  323. HARTUNG T, Von Aulock S, Schneider C, Faist E
    How to leverage an endogenous immune defense mechanism: the example of granulocyte colony-stimulating factor.
    Crit Care Med 2003; 31: S65-75.
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  324. OPAL SM, Gluck T
    Endotoxin as a drug target.
    Crit Care Med 2003; 31: S57-64.
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  325. CZURA CJ, Tracey KJ
    Targeting high mobility group box 1 as a late-acting mediator of inflammation.
    Crit Care Med 2003; 31: S46-50.
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  326. SALVEMINI D, Cuzzocrea S
    Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine.
    Crit Care Med 2003; 31: S29-38.
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