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	The Medical Article of the Year 2008: Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78. Free full-text

Pulmonary Hypertension

Free Subscription Articles published in Am J Physiol Lung Cell Mol Physiol Retrieve available abstracts of 60 articles: HTML format

Single Articles

July 2008
1. GIEN J , Seedorf GJ, Balasubramaniam V, Tseng N, et al
   Chronic Intrauterine Pulmonary Hypertension Increases Endothelial Cell Rho-Kinase Activity and Impairs Angiogenesis in vitro.
   Am J Physiol Lung Cell Mol Physiol. 2008;.
   PubMed     Related articles    Abstract available
   
   
   June 2008
2. HUANG J , Kaminski PM, Edwards JG, Yeh A, et al
   Pyrrolidine dithiocarbamate restores endothelial cell membrane integrity and attenuates monocrotaline-induced pulmonary artery hypertension.
   Am J Physiol Lung Cell Mol Physiol. 2008;294:L1250-9.
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   May 2008
3. COSTELLO CM , Howell K, Cahill E, McBryan J, et al
   Lung Selective Gene Responses to Alveolar Hypoxia: Potential Role for the Bone Morphogenetic Antagonist Gremlin in Pulmonary Hypertension.
   Am J Physiol Lung Cell Mol Physiol. 2008;.
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4. HOMMA N , Nagaoka T, Karoor V, Imamura M, et al
   Involvement of RhoA/Rho kinase signaling in dehydroepiandrosterone's protection against monocrotaline-induced pulmonary hypertension in pneumonectomized rats.
   Am J Physiol Lung Cell Mol Physiol. 2008;.
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5. MANIATIS NA , Shinin V, Schraufnagel DE, Okada S, et al
   Increased pulmonary vascular resistance and defective pulmonary artery filling in caveolin-1-/- mice.
   Am J Physiol Lung Cell Mol Physiol. 2008;294:L865-73.
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   April 2008
6. CHURG A , Cosio M, Wright JL
   Mechanisms of cigarette smoke-induced COPD: insights from animal models.
   Am J Physiol Lung Cell Mol Physiol. 2008;294:L612-31.
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   March 2008
7. MUKHOPADHYAY S , Shah M, Xu F, Patel K, et al
   Cytoplasmic provenance of STAT3 and PY-STAT3 in the endolysosomal compartments in pulmonary arterial endothelial and smooth muscle cells: implications in pulmonary arterial hypertension.
   Am J Physiol Lung Cell Mol Physiol. 2008;294:L449-68.
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   February 2008
8. RYTER SW , Choi AM
   Caveolin-1: A Critical Regulator of Pulmonary Vascular Architecture and Nitric Oxide Bioavailability in Pulmonary Hypertension.
   Am J Physiol Lung Cell Mol Physiol. 2008;.
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9. LEUCHTE HH , Meis T, El-Nounou M, Michalek J, et al
   Inhalation of Endothelin receptor blockers in pulmonary hypertension.
   Am J Physiol Lung Cell Mol Physiol. 2008;.
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10. SPIEKERKOETTER E , Alvira CM, Kim YM, Bruneau A, et al
    Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin.
    Am J Physiol Lung Cell Mol Physiol. 2008;294:L276-89.
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    December 2007
11. JANKOV RP , Kantores C, Pan J, Belik J, et al
    Contribution of Xanthine Oxidase-Derived Superoxide to Chronic Hypoxic Pulmonary Hypertension in Neonatal Rats.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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    November 2007
12. MCNAMARA PJ , Murthy P, Kantores C, Teixeira L, et al
    Acute Vasodilator Effects of Rho-Kinase Inhibitors in Neonatal Rats with Pulmonary Hypertension Unresponsive to Nitric Oxide.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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13. SHARMA S , Sud N, Wiseman DA, Carter AL, et al
    Altered Carnitine Homeostasis is Associated with Decreased Mitochondrial Function and Altered Nitric Oxide Signaling in Lambs with Pulmonary Hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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14. FRANK DB , Lowery JW, Anderson L, Brink M, et al
    Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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    October 2007
15. HEMNES AR , Zaiman A, Champion HC
    PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS Generation and RhoA/Rho kinase Activation.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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16. MCMURTRY MS , Bonnet S, Michelakis ED, Bonnet S, et al
    Statin therapy, alone or with rapamycin, does not reverse monocrotaline pulmonary arterial hypertension: the rapamcyin-atorvastatin-simvastatin study.
    Am J Physiol Lung Cell Mol Physiol. 2007;293:L933-40.
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    September 2007
17. BAUER NR , Moore TM, McMurtry IF
    Rodent models of PAH: are we there yet?
    Am J Physiol Lung Cell Mol Physiol. 2007;293:L580-2.
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18. STEVENS T , Gillespie MN
    The hyperproliferative endothelial cell phenotype in idiopathic pulmonary arterial hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2007;293:L546-7.
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19. WHITE RJ , Meoli DF, Swarthout RF, Kallop DY, et al
    Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2007;293:L583-90.
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20. MASRI FA , Xu W, Comhair SA, Asosingh K, et al
    Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2007;293:L548-54.
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    August 2007
21. IZIKKI M , Hanoun N, Marcos E, Savale L, et al
    Tryptophan Hydroxylase 1 (Tph1) Knock-Out and Tph2 Polymorphism: Effects on Hypoxic Pulmonary Hypertension in Mice.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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22. BARMAN SA
    Vasoconstrictor effect of endothelin-1 on hypertensive pulmonary arterial smooth muscle involves Rho-kinase and protein kinase C.
    Am J Physiol Lung Cell Mol Physiol. 2007;293:L472-9.
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    June 2007
23. LAUDI S , Trump S, Schmitz V, West J, et al
    Serotonin Transporter Protein in Pulmonary Hypertensive Lungs Treated with Atorvastatin.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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24. TADA Y , Majka S, Carr M, Harral J, et al
    Molecular effects of loss of BMPR2 signaling in smooth muscle in a transgenic mouse model of PAH.
    Am J Physiol Lung Cell Mol Physiol. 2007;292:L1556-63.
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25. HAGEN M , Fagan K, Steudel W, Carr M, et al
    Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle.
    Am J Physiol Lung Cell Mol Physiol. 2007;292:L1473-9.
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    May 2007
26. ZHANG S , Patel HH, Murray F, Remillard CV, et al
    Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry.
    Am J Physiol Lung Cell Mol Physiol. 2007;292:L1202-10.
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    April 2007
27. CROSSNO JT JR , Garat CV, Reusch JE, Morris KG, et al
    Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling.
    Am J Physiol Lung Cell Mol Physiol. 2007;292:L885-97.
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28. MCMURTRY MS , Moudgil R, Hashimoto K, Bonnet S, et al
    Overexpression of human bone morphogenetic protein receptor 2 does not ameliorate monocrotaline pulmonary arterial hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2007;292:L872-8.
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    March 2007
29. ARCINIEGAS E , Frid MG, Douglas IS, Stenmark KR, et al
    Perspectives on Endothelial-Mesenchymal Transition: Potential Contribution to Vascular Remodeling in Chronic Pulmonary Hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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30. SEHGAL PB , Mukhopadhyay S, Xu F, Patel K, et al
    Dysfunction of Golgi tethers, SNAREs and SNAPs in monocrotaline-induced pulmonary hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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    February 2007
31. SASAKI A , Doi S, Mizutani S, Azuma H, et al
    Roles of accumulated endogenous NOS inhibitors, enhanced arginase activity, and attenuated NOS activity in endothelial cells for pulmonary hypertension in rats.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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32. REYNOLDS AM , Xia W, Holmes MD, Hodge SJ, et al
    Bone morphogenetic protein type 2 receptor (BMPR2) gene therapy attenuates hypoxic pulmonary hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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33. GIRGIS RE , Mozammel S, Champion HC, Li D, et al
    Regression of Chronic Hypoxic Pulmonary Hypertension by Simvastatin.
    Am J Physiol Lung Cell Mol Physiol. 2007;.
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    December 2006
34. RESNIK ER , Keck M, Sukovich DJ, Herron JM, et al
    Chronic intrauterine pulmonary hypertension increases capacitative calcium entry in fetal pulmonary artery smooth muscle cells.
    Am J Physiol Lung Cell Mol Physiol. 2006;.
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    November 2006
35. LAGNA G , Nguyen PH, Ni W, Hata A, et al
    BMP-dependent activation of caspase-9 and caspase-8 mediates apoptosis in pulmonary artery smooth muscle cells.
    Am J Physiol Lung Cell Mol Physiol. 2006;291:L1059-67.
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36. FANTOZZI I , Platoshyn O, Wong AH, Zhang S, et al
    Bone morphogenetic protein-2 upregulates expression and function of voltage-gated K+ channels in human pulmonary artery smooth muscle cells.
    Am J Physiol Lung Cell Mol Physiol. 2006;291:L993-1004.
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    October 2006
37. IHIDA-STANSBURY K , McKean DM, Lane KB, Loyd JE, et al
    Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2006;291:L694-702.
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38. SAID SI
    Mediators and modulators of pulmonary arterial hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2006;291:L547-58.
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    September 2006
39. MURRAY F , Patel HH, Suda RY, Zhang S, et al
    Expression and Activity of cAMP Phosphodiesterase Isoforms in Pulmonary Artery Smooth Muscle Cells from Patients with Pulmonary Hypertension: Role for PDE1.
    Am J Physiol Lung Cell Mol Physiol. 2006;.
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40. CASE D , Irwin D, Ivestor C, Harral J, et al
    Mice Deficient in Galectin-1 Exhibit Attenuated Physiological Responses to Chronic Hypoxia Induced Pulmonary Hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2006;.
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    July 2006
41. FIKE CD , Kaplowitz MR, Zhang Y, Madden JA, et al
    Voltage-gated K+ channels at an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets.
    Am J Physiol Lung Cell Mol Physiol. 2006;.
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42. KANTORES C , McNamara PJ, Teixeira L, Engelberts D, et al
    Therapeutic Hypercapnia Prevents Chronic Hypoxia-Induced Pulmonary Hypertension in the Newborn Rat.
    Am J Physiol Lung Cell Mol Physiol. 2006;.
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    June 2006
43. GROBE AC , Wells SM, Benavidez E, Oishi P, et al
    Increased oxidative stress in lambs with increased pulmonary blood flow and pulmonary hypertension: role of NADPH oxidase and endothelial NO synthase.
    Am J Physiol Lung Cell Mol Physiol. 2006;290:L1069-77.
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    May 2006
44. TARASEVICIENE-STEWART L , Scerbavicius R, Choe KH, Cool C, et al
    Simvastatin Causes Endothelial Cell Apoptosis and Attenuates Severe Pulmonary Hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2006;.
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45. YOUNG KA , Ivester C, West J, Carr M, et al
    BMP signaling controls PASMC KV channel expression in vitro and in vivo.
    Am J Physiol Lung Cell Mol Physiol. 2006;290:L841-8.
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    March 2006
46. RESNIK E , Herron J, Keck M, Sukovich D, et al
    Chronic intrauterine pulmonary hypertension selectively modifies pulmonary artery smooth muscle cell gene expression.
    Am J Physiol Lung Cell Mol Physiol. 2006;290:L426-33.
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47. JERNIGAN NL , Broughton BR, Walker BR, Resta TC, et al
    Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia.
    Am J Physiol Lung Cell Mol Physiol. 2006;290:L517-25.
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48. WANG X , Tong M, Chinta S, Raj JU, et al
    Hypoxia-induced reactive oxygen species downregulate ETB receptor-mediated contraction of rat pulmonary arteries.
    Am J Physiol Lung Cell Mol Physiol. 2006;290:L570-8.
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    February 2006
49. VOELKEL NF , Vandivier RW, Tuder RM
    Vascular endothelial growth factor in the lung.
    Am J Physiol Lung Cell Mol Physiol. 2006;290:L209-21.
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50. HINTON M , Mellow L, Halayko AJ, Gutsol A, et al
    Hypoxia induces hypersensitivity and hyperreactivity to thromboxane receptor agonist in neonatal pulmonary arterial myocytes.
    Am J Physiol Lung Cell Mol Physiol. 2006;290:L375-84.
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51. PRESTON IR , Hill NS, Warburton RR, Fanburg BL, et al
    Role of 12-lipoxygenase in hypoxia-induced rat pulmonary artery smooth muscle cell proliferation.
    Am J Physiol Lung Cell Mol Physiol. 2006;290:L367-74.
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    January 2006
52. WOJCIAK-STOTHARD B , Tsang LY, Paleolog E, Hall SM, et al
    Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2006;.
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    December 2005
53. TAKAHASHI H , Goto N, Kojima Y, Tsuda Y, et al
    Down-regulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension.
    Am J Physiol Lung Cell Mol Physiol. 2005;.
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54. LITTLER CM , Wehling CA, Wick MJ, Fagan KA, et al
    Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia.
    Am J Physiol Lung Cell Mol Physiol. 2005;289:L1083-93.
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    November 2005
55. EVGENOV OV , Busch CJ, Evgenov NV, Liu R, et al
    Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension.
    Am J Physiol Lung Cell Mol Physiol 2005;.
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56. RIOS EJ , Fallon M, Wang J, Shimoda LA, et al
    Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells.
    Am J Physiol Lung Cell Mol Physiol 2005;289:L867-74.
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    October 2005
57. OISHI P , Grobe A, Benavidez E, Ovadia B, et al
    Inhaled Nitric Oxide Induced NOS Inhibition and Rebound Pulmonary Hypertension: A role for superoxide and peroxynitrite in the intact lamb.
    Am J Physiol Lung Cell Mol Physiol 2005;.
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    August 2005
58. HAMPL V , Bibova J, Banasova A, Uhlik J, et al
    Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension.
    Am J Physiol Lung Cell Mol Physiol 2005;.
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59. LIU JQ , Zelko IN, Erbynn EM, Sham JS, et al
    Hypoxic pulmonary hypertension: Role of superoxide and NADPH oxidase (gp91phox).
    Am J Physiol Lung Cell Mol Physiol 2005;.
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60. MILLER AA , Hislop AA, Vallance PJ, Haworth SG, et al
    Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice.
    Am J Physiol Lung Cell Mol Physiol 2005;289:L299-306.
    PubMed     Related articles    Abstract available
    
    

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