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  Obesity

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Articles published in Proc Natl Acad Sci U S A

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    March 2015
  1. NASIF S, de Souza FS, Gonzalez LE, Yamashita M, et al
    Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood.
    Proc Natl Acad Sci U S A. 2015 Mar 30. pii: 201500672.
    PubMed     Text format     Abstract available


    January 2015
  2. CIPOLLETTA D, Cohen P, Spiegelman BM, Benoist C, et al
    Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARgamma effects.
    Proc Natl Acad Sci U S A. 2015;112:482-7.
    PubMed     Text format     Abstract available


  3. LOPEZ-VICARIO C, Alcaraz-Quiles J, Garcia-Alonso V, Rius B, et al
    Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: role for omega-3 epoxides.
    Proc Natl Acad Sci U S A. 2015;112:536-41.
    PubMed     Text format     Abstract available


  4. ROSENQUIST JN, Lehrer SF, O'Malley AJ, Zaslavsky AM, et al
    Cohort of birth modifies the association between FTO genotype and BMI.
    Proc Natl Acad Sci U S A. 2015;112:354-9.
    PubMed     Text format     Abstract available


  5. BOWLES NP, Karatsoreos IN, Li X, Vemuri VK, et al
    A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome.
    Proc Natl Acad Sci U S A. 2015;112:285-90.
    PubMed     Text format     Abstract available


    December 2014
  6. PAZ JC, Park S, Phillips N, Matsumura S, et al
    Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.
    Proc Natl Acad Sci U S A. 2014;111:17116-21.
    PubMed     Text format     Abstract available


  7. MCHILL AW, Melanson EL, Higgins J, Connick E, et al
    Impact of circadian misalignment on energy metabolism during simulated nightshift work.
    Proc Natl Acad Sci U S A. 2014;111:17302-7.
    PubMed     Text format     Abstract available


    October 2014
  8. HONEK J, Seki T, Iwamoto H, Fischer C, et al
    Modulation of age-related insulin sensitivity by VEGF-dependent vascular plasticity in adipose tissues.
    Proc Natl Acad Sci U S A. 2014;111:14906-11.
    PubMed     Text format     Abstract available


  9. HORVATH S, Erhart W, Brosch M, Ammerpohl O, et al
    Obesity accelerates epigenetic aging of human liver.
    Proc Natl Acad Sci U S A. 2014 Oct 13. pii: 201412759.
    PubMed     Text format     Abstract available


  10. WU L, Parekh VV, Hsiao J, Kitamura D, et al
    Spleen supports a pool of innate-like B cells in white adipose tissue that protects against obesity-associated insulin resistance.
    Proc Natl Acad Sci U S A. 2014 Oct 13. pii: 201324052.
    PubMed     Text format     Abstract available


  11. TAJAN M, Batut A, Cadoudal T, Deleruyelle S, et al
    LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.
    Proc Natl Acad Sci U S A. 2014 Oct 6. pii: 201406107.
    PubMed     Text format     Abstract available


    September 2014
  12. MA X, Xu L, Gavrilova O, Mueller E, et al
    Role of forkhead box protein A3 in age-associated metabolic decline.
    Proc Natl Acad Sci U S A. 2014;111:14289-94.
    PubMed     Text format     Abstract available


    July 2014
  13. LEE JH, Bassel-Duby R, Olson EN
    Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila.
    Proc Natl Acad Sci U S A. 2014;111:9491-6.
    PubMed     Text format     Abstract available


    June 2014
  14. FREDERICK CB, Snellman K, Putnam RD
    Reply to Gao et al: Racial composition does not explain increasing class gaps in obesity.
    Proc Natl Acad Sci U S A. 2014;111:E2238.
    PubMed     Text format    


    May 2014
  15. SJOLUND J, Pelorosso FG, Quigley DA, DelRosario R, et al
    Identification of Hipk2 as an essential regulator of white fat development.
    Proc Natl Acad Sci U S A. 2014;111:7373-8.
    PubMed     Text format     Abstract available


  16. YONGQING G, Gordon J, Sun W
    Is poverty associated with obesity among American children?
    Proc Natl Acad Sci U S A. 2014 May 19. pii: 201405656.
    PubMed     Text format    


    April 2014
  17. CANAAN A, Defuria J, Perelman E, Schultz V, et al
    Extended lifespan and reduced adiposity in mice lacking the FAT10 gene.
    Proc Natl Acad Sci U S A. 2014;111:5313-8.
    PubMed     Text format     Abstract available


    February 2014

  18. Correction for Chatzigeorgiou et al., Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
    Proc Natl Acad Sci U S A. 2014.
    PubMed     Text format    


  19. CHATZIGEORGIOU A, Seijkens T, Zarzycka B, Engel D, et al
    Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.
    Proc Natl Acad Sci U S A. 2014.
    PubMed     Text format     Abstract available


    January 2014
  20. FREDERICK CB, Snellman K, Putnam RD
    Increasing socioeconomic disparities in adolescent obesity.
    Proc Natl Acad Sci U S A. 2014;111:1338-42.
    PubMed     Text format     Abstract available


    December 2013
  21. CHA JY, Kim HJ, Yu JH, Xu J, et al
    Dexras1 mediates glucocorticoid-associated adipogenesis and diet-induced obesity.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


    November 2013
  22. LIU J, Cinar R, Xiong K, Godlewski G, et al
    Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase.
    Proc Natl Acad Sci U S A. 2013;110:18832-7.
    PubMed     Text format     Abstract available


  23. WANG F, Mullican SE, DiSpirito JR, Peed LC, et al
    Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPARgamma.
    Proc Natl Acad Sci U S A. 2013;110:18656-61.
    PubMed     Text format     Abstract available


    October 2013
  24. SHIRAZI R, Palsdottir V, Collander J, Anesten F, et al
    Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6.
    Proc Natl Acad Sci U S A. 2013;110:16199-204.
    PubMed     Text format     Abstract available


    August 2013
  25. GOLDLUST IS , Hermetz KE, Catalano LM, Barfield RT, et al
    Mouse model implicates GNB3 duplication in a childhood obesity syndrome.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


  26. POWELL WT, Coulson RL, Gonzales ML, Crary FK, et al
    R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation.
    Proc Natl Acad Sci U S A. 2013;110:13938-43.
    PubMed     Text format     Abstract available


  27. PATTI ME
    Reducing maternal weight improves offspring metabolism and alters (or modulates) methylation.
    Proc Natl Acad Sci U S A. 2013;110:12859-60.
    PubMed     Text format    


  28. RUBIN H
    Promotion and selection by serum growth factors drive field cancerization, which is anticipated in vivo by type 2 diabetes and obesity.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


    July 2013
  29. PRICEMAN SJ , Kujawski M, Shen S, Cherryholmes GA, et al
    Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


  30. LEE KY , Yamamoto Y, Boucher J, Winnay JN, et al
    Shox2 is a molecular determinant of depot-specific adipocyte function.
    Proc Natl Acad Sci U S A. 2013;110:11409-14.
    PubMed     Text format     Abstract available


  31. GUENARD F , Deshaies Y, Cianflone K, Kral JG, et al
    Differential methylation in glucoregulatory genes of offspring born before vs. after maternal gastrointestinal bypass surgery.
    Proc Natl Acad Sci U S A. 2013;110:11439-44.
    PubMed     Text format     Abstract available


    June 2013
  32. CONE RD
    QnAs with Roger D. Cone.
    Proc Natl Acad Sci U S A. 2013;110:9618.
    PubMed     Text format    


  33. XU P , Grueter BA, Britt JK, McDaniel L, et al
    Double deletion of melanocortin 4 receptors and SAPAP3 corrects compulsive behavior and obesity in mice.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


    May 2013
  34. UPADHYAY SK , Eckel-Mahan KL, Mirbolooki MR, Tjong I, et al
    Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


  35. ALPAR A , Harkany T
    Orexin neurons use endocannabinoids to break obesity-induced inhibition.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format    


  36. WILLIAMS SC
    Link between obesity and cancer.
    Proc Natl Acad Sci U S A. 2013;110:8753-4.
    PubMed     Text format    


  37. AOUADI M , Tencerova M, Vangala P, Yawe JC, et al
    Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice.
    Proc Natl Acad Sci U S A. 2013;110:8278-83.
    PubMed     Text format     Abstract available


  38. EVERARD A , Belzer C, Geurts L, Ouwerkerk JP, et al
    Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


    April 2013
  39. CRISTINO L , Busetto G, Imperatore R, Ferrandino I, et al
    Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


  40. PANARO BL , Cone RD
    Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods.
    Proc Natl Acad Sci U S A. 2013;110:7050-5.
    PubMed     Text format     Abstract available


  41. BERBARI NF , Pasek RC, Malarkey EB, Yazdi SM, et al
    Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


    March 2013
  42. DEFURIA J , Belkina AC, Jagannathan-Bogdan M, Snyder-Cappione J, et al
    B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


    February 2013

  43. Correction for Millership et al., Increased lipolysis and altered lipid homeostasis protect gamma-synuclein-null mutant mice from diet-induced obesity.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format    


    January 2013
  44. GULATI P , Cheung MK, Antrobus R, Church CD, et al
    Role for the obesity-related FTO gene in the cellular sensing of amino acids.
    Proc Natl Acad Sci U S A. 2013.
    PubMed     Text format     Abstract available


  45. MITRA MS , Chen Z, Ren H, Harris TE, et al
    Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
    Proc Natl Acad Sci U S A. 2013;110:642-7.
    PubMed     Text format     Abstract available


    December 2012
  46. KANTOMAA MT , Stamatakis E, Kankaanpaa A, Kaakinen M, et al
    Physical activity and obesity mediate the association between childhood motor function and adolescents' academic achievement.
    Proc Natl Acad Sci U S A. 2012.
    PubMed     Text format     Abstract available


  47. MILLERSHIP S , Ninkina N, Guschina IA, Norton J, et al
    Increased lipolysis and altered lipid homeostasis protect gamma-synuclein-null mutant mice from diet-induced obesity.
    Proc Natl Acad Sci U S A. 2012.
    PubMed     Text format     Abstract available


    October 2012
  48. FRAKER PJ
    Profile of Pamela J. Fraker. Interview by Tinsley H. Davis.
    Proc Natl Acad Sci U S A. 2012;109:16754-5.
    PubMed     Text format    


    September 2012
  49. CARRER M , Liu N, Grueter CE, Williams AH, et al
    Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378*.
    Proc Natl Acad Sci U S A. 2012;109:15330-5.
    PubMed     Text format     Abstract available


  50. FU T , Choi SE, Kim DH, Seok S, et al
    Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor beta-Klotho.
    Proc Natl Acad Sci U S A. 2012.
    PubMed     Text format     Abstract available


    May 2012
  51. TROTTIER MD , Naaz A, Li Y, Fraker PJ, et al
    Enhancement of hematopoiesis and lymphopoiesis in diet-induced obese mice.
    Proc Natl Acad Sci U S A. 2012;109:7622-9.
    PubMed     Text format     Abstract available


  52. RABINOVITZ S , Kaufman Y, Ludwig G, Razin A, et al
    Mechanisms of activation of the paternally expressed genes by the Prader-Willi imprinting center in the Prader-Willi/Angelman syndromes domains.
    Proc Natl Acad Sci U S A. 2012;109:7403-8.
    PubMed     Text format     Abstract available


  53. WEIDNER C , de Groot JC, Prasad A, Freiwald A, et al
    Amorfrutins are potent antidiabetic dietary natural products.
    Proc Natl Acad Sci U S A. 2012;109:7257-62.
    PubMed     Text format     Abstract available


  54. WU L , Parekh VV, Gabriel CL, Bracy DP, et al
    Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice.
    Proc Natl Acad Sci U S A. 2012;109:E1143-52.
    PubMed     Text format     Abstract available


    April 2012
  55. KODAMA K , Horikoshi M, Toda K, Yamada S, et al
    Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes.
    Proc Natl Acad Sci U S A. 2012.
    PubMed     Text format     Abstract available


    March 2012
  56. ZHANG Y , Li Y, Niepel MW, Kawano Y, et al
    Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance.
    Proc Natl Acad Sci U S A. 2012.
    PubMed     Text format     Abstract available


    February 2012
  57. DUBOSE AJ , Smith EY, Johnstone KA, Resnick JL, et al
    Temporal and developmental requirements for the Prader-Willi imprinting center.
    Proc Natl Acad Sci U S A. 2012;109:3446-50.
    PubMed     Text format     Abstract available


  58. WU Q , Whiddon BB, Palmiter RD
    Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.
    Proc Natl Acad Sci U S A. 2012;109:3155-60.
    PubMed     Text format     Abstract available


    December 2011
  59. FELDMAN DE , Chen C, Punj V, Tsukamoto H, et al
    Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells.
    Proc Natl Acad Sci U S A. 2011.
    PubMed     Text format     Abstract available


  60. GREENBLUM S , Turnbaugh PJ, Borenstein E
    Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease.
    Proc Natl Acad Sci U S A. 2011.
    PubMed     Text format     Abstract available


    November 2011
  61. STAQUICINI FI , Cardo-Vila M, Kolonin MG, Trepel M, et al
    Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients.
    Proc Natl Acad Sci U S A. 2011;108:18637-42.
    PubMed     Text format     Abstract available


    October 2011
  62. YANG RY , Yu L, Graham JL, Hsu DK, et al
    Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice.
    Proc Natl Acad Sci U S A. 2011.
    PubMed     Text format     Abstract available


    September 2011
  63. BECATTINI B , Marone R, Zani F, Arsenijevic D, et al
    PI3K{gamma} within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.
    Proc Natl Acad Sci U S A. 2011.
    PubMed     Text format     Abstract available


  64. MAO T , Shao M, Qiu Y, Huang J, et al
    PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism.
    Proc Natl Acad Sci U S A. 2011;108:15852-7.
    PubMed     Text format     Abstract available


  65. HANLON EC , Van Cauter E
    Quantification of sleep behavior and of its impact on the cross-talk between the brain and peripheral metabolism.
    Proc Natl Acad Sci U S A. 2011;108 Suppl 3:15609-16.
    PubMed     Text format     Abstract available


    August 2011
  66. STIENSTRA R , van Diepen JA, Tack CJ, Zaki MH, et al
    Inflammasome is a central player in the induction of obesity and insulin resistance.
    Proc Natl Acad Sci U S A. 2011.
    PubMed     Text format     Abstract available


    July 2011
  67. KUROKAWA J , Nagano H, Ohara O, Kubota N, et al
    Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue.
    Proc Natl Acad Sci U S A. 2011.
    PubMed     Text format     Abstract available


    May 2011
  68. LURIA A , Bettaieb A, Xi Y, Shieh GJ, et al
    Soluble epoxide hydrolase deficiency alters pancreatic islet size and improves glucose homeostasis in a model of insulin resistance.
    Proc Natl Acad Sci U S A. 2011;108:9038-43.
    PubMed     Text format     Abstract available


    March 2011
  69. KOBAYASHI N , Ueki K, Okazaki Y, Iwane A, et al
    Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance.
    Proc Natl Acad Sci U S A. 2011.
    PubMed     Text format     Abstract available


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