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Obesity

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January 2010
1. SANDHOLT CH , Sparso T, Grarup N, Albrechtsen A, et al
   Combined analyses of 20 common obesity susceptibility variants.
   Diabetes. 2010.
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2. KIEFER FW , Zeyda M, Gollinger K, Pfau B, et al
   Neutralization of osteopontin inhibits obesity-induced inflammation and insulin resistance.
   Diabetes. 2010.
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3. OBSTFELD AE , Sugaru E, Thearle M, Francisco AM, et al
   CCR2 regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis.
   Diabetes. 2010.
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4. CHAN CB , Liu X, Jung DY, Jun JY, et al
   Deficiency of PIKE Protects Mice from Diet-induced Obesity and Insulin Resistance.
   Diabetes. 2010.
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5. LAW IK , Xu A, Lam KS, Berger T, et al
   Lipocalin-2 deficiency attenuates insulin resistance associated with ageing and obesity.
   Diabetes. 2010.
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   December 2009
6. KOLKA CM , Harrison LN, Lottati M, Chiu JD, et al
   Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle.
   Diabetes. 2009.
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7. LING C , Groop L
   Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes.
   Diabetes. 2009;58:2718-2725.
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8. NAVAB M , Anantharamaiah GM, Reddy ST, Van Lenten BJ, et al
   HDL as a biomarker, potential therapeutic target, and therapy.
   Diabetes. 2009;58:2711-7.
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9. SELL H , Laurencikiene J, Taube A, Eckardt K, et al
   Chemerin is a novel adipocyte-derived factor inducing insulin resistance in primary human skeletal muscle cells.
   Diabetes. 2009;58:2731-40.
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   October 2009
10. PADMAVATHI IJ , Rao KR, Venu L, Ganeshan M, et al
    Chronic maternal dietary chromium restriction modulates visceral adiposity: probable underlying mechanisms.
    Diabetes. 2009.
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11. CHENG S , Massaro JM, Fox CS, Larson MG, et al
    Adiposity, Cardiometabolic Risk, and Vitamin D Status: the Framingham Heart Study.
    Diabetes. 2009.
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12. KARAKELIDES H , Irving BA, Short KR, O'Brien P, et al
    Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function.
    Diabetes. 2009.
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13. HWANG H , Bowen BP, Lefort N, Flynn CR, et al
    Proteomics Analysis of Human Skeletal Muscle Reveals Novel Abnormalities in Obesity and Type 2 Diabetes Mellitus.
    Diabetes. 2009.
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14. YE R , Jung DY, Jun JY, Li J, et al
    Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance.
    Diabetes. 2009.
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15. JAGER J , Gremeaux T, Gonzalez T, Bonnafous S, et al
    The Tpl2 kinase is up-regulated in adipose tissue in obesity and may mediate IL-1{beta} and TNF-{alpha} effects on ERK activation and lipolysis.
    Diabetes. 2009.
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16. GRUNNET LG , Nilsson E, Ling C, Hansen T, et al
    Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue.
    Diabetes. 2009;58:2402-8.
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    September 2009
17. ZILLIKENS MC , van Meurs JB, Rivadeneira F, Amin N, et al
    SIRT1 genetic variation is related to body mass index and risk of obesity.
    Diabetes. 2009.
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18. MAMANE Y , Chung Chan C, Lavallee G, Morin N, et al
    The C3a anaphylatoxin receptor is a key mediator of insulin resistance and functions by modulating adipose tissue macrophage infiltration and activation.
    Diabetes. 2009;58:2006-17.
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    August 2009
19. MIYASHITA K , Itoh H, Tsujimoto H, Tamura N, et al
    Natriuretic Peptides/cGMP/cGMP-dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity.
    Diabetes. 2009.
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20. SEO J , Fortuno ES 3rd, Suh JM, Stenesen D, et al
    Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure.
    Diabetes. 2009.
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21. YEH TY , Beiswenger KK, Li P, Bolin KE, et al
    Hypermetabolism, hyperphagia, and reduced adiposity in tankyrase-deficient mice.
    Diabetes. 2009.
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22. CEFALU WT
    Primary prevention of type 2 diabetes: there are no simple solutions!
    Diabetes. 2009;58:1730-1.
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23. KOS K , Wong S, Tan B, Gummesson A, et al
    Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose.
    Diabetes. 2009;58:1780-8.
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24. LEFTEROVA MI , Mullican SE, Tomaru T, Qatanani M, et al
    Endoplasmic reticulum stress regulates adipocyte resistin expression.
    Diabetes. 2009;58:1879-86.
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    July 2009
25. POCAI A , Carrington PE, Adams JR, Michael W, et al
    GLP-1/GCGR dual agonism reverses obesity in mice.
    Diabetes. 2009.
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26. COLOMBANI AL , Carneiro L, Benani A, Galinier A, et al
    Enhanced Hypothalamic Glucose Sensing in Obesity: Alteration of Redox Signalling.
    Diabetes. 2009.
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27. SEALE P , Lazar MA
    Brown fat in humans: turning up the heat on obesity.
    Diabetes. 2009;58:1482-4.
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28. MAI K , Andres J, Biedasek K, Weicht J, et al
    Free fatty acids link metabolism and regulation of the insulin-sensitizing fibroblast growth factor-21.
    Diabetes. 2009;58:1532-8.
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29. TRAURIG M , Mack J, Hanson RL, Ghoussaini M, et al
    Common variation in SIM1 is reproducibly associated with BMI in Pima Indians.
    Diabetes. 2009;58:1682-9.
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30. GAO Z , Yin J, Zhang J, Ward RE, et al
    Butyrate improves insulin sensitivity and increases energy expenditure in mice.
    Diabetes. 2009;58:1509-17.
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    June 2009
31. BOTTCHER Y , Unbehauen H, Kloting N, Ruschke K, et al
    Adipose Tissue Expression and Genetic Variants of the Bone Morphogenetic Protein Receptor 1A Gene (BMPR1A) are Associated with Human Obesity.
    Diabetes. 2009.
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32. STANCAKOVA A , Kuulasmaa T, Paananen J, Jackson AU, et al
    Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes with Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5 327 Non-diabetic Finnish Men.
    Diabetes. 2009.
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    May 2009
33. STRAZNICKY NE , Lambert GW, McGrane MT, Masuo K, et al
    Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome.
    Diabetes. 2009;58:1126-32.
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    April 2009
34. SAITO M , Okamatsu-Ogura Y, Matsushita M, Watanabe K, et al
    High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity.
    Diabetes. 2009.
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35. CAPEL F , Klimcakova E, Viguerie N, Roussel B, et al
    Macrophages and Adipocytes in Human Obesity: Adipose Tissue Gene Expression and Insulin Sensitivity during Calorie Restriction and Weight Stabilization.
    Diabetes. 2009.
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36. BASU R , Chandramouli V, Schumann W, Basu A, et al
    Additional Evidence That Transaldolase Exchange, Isotope Discrimination during the Triose-Isomerase Reaction or Both Occurs in Humans: Effects of Type 2 Diabetes.
    Diabetes. 2009.
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37. ISAKSON P , Hammarstedt A, Gustafson B, Smith U, et al
    Impaired preadipocyte differentiation in human abdominal obesity -- role of Wnt, TNF{alpha} and inflammation.
    Diabetes. 2009.
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38. DEFRONZO RA
    Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.
    Diabetes. 2009;58:773-95.
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39. KINDBLOM JM , Lorentzon M, Hellqvist A, Lonn L, et al
    BMI changes during childhood and adolescence as predictors of amount of adult subcutaneous and visceral adipose tissue in men: the GOOD Study.
    Diabetes. 2009;58:867-74.
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40. MATVEYENKO AV , Gurlo T, Daval M, Butler AE, et al
    Successful versus failed adaptation to high-fat diet-induced insulin resistance: the role of IAPP-induced beta-cell endoplasmic reticulum stress.
    Diabetes. 2009;58:906-16.
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    March 2009
41. BODEN G
    Endoplasmic reticulum stress: another link between obesity and insulin resistance/inflammation?
    Diabetes. 2009;58:518-9.
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42. MANTOVANI G , Bondioni S, Alberti L, Gilardini L, et al
    Protein kinase A regulatory subunits in human adipose tissue: decreased R2B expression and activity in adipocytes from obese subjects.
    Diabetes. 2009;58:620-6.
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43. PADMALAYAM I , Hasham S, Saxena U, Pillarisetti S, et al
    Lipoic acid synthase (LASY): a novel role in inflammation, mitochondrial function, and insulin resistance.
    Diabetes. 2009;58:600-8.
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44. GREGOR MF , Yang L, Fabbrini E, Mohammed BS, et al
    Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss.
    Diabetes. 2009;58:693-700.
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45. YOUN BS , Bang SI, Kloting N, Park JW, et al
    Serum progranulin concentrations may be associated with macrophage infiltration into omental adipose tissue.
    Diabetes. 2009;58:627-36.
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    February 2009
46. CLOUGH G , Turzyniecka M, Walter L, Krentz A, et al
    Muscle Microvascular Dysfunction in Central Obesity is Related to Muscle Insulin Insensitivity but is not Reversed by High-Dose Statin Treatment.
    Diabetes. 2009.
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47. WILKES JJ , Lloyd DJ, Gekakis N
    A LOSS-OF-FUNCTION MUTATION IN MYOSTATIN REDUCES TNF{alpha} PRODUCTION AND PROTECTS LIVER AGAINST OBESITY-INDUCED INSULIN RESISTANCE.
    Diabetes. 2009.
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48. TAMASHIRO KL , Terrillion CE, Hyun J, Koenig JI, et al
    Prenatal Stress or High Fat Diet increases Susceptibility to Diet-Induced Obesity in Rat Offspring.
    Diabetes. 2009.
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49. XIE H , Lim B, Lodish HF
    MicroRNAs Induced during Adipogenesis That Accelerate Fat Cell Development Are Downregulated in Obesity.
    Diabetes. 2009.
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50. LINDSAY RS
    Many HAPO returns: maternal glycemia and neonatal adiposity: new insights from the Hyperglycemia and Adverse Pregnancy Outcomes (HAPO) study.
    Diabetes. 2009;58:302-3.
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51. CEFALU WT
    Inflammation, insulin resistance, and type 2 diabetes: back to the future?
    Diabetes. 2009;58:307-8.
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    January 2009
52. STEINBERG GR , Watt MJ, Ernst M, Birnbaum MJ, et al
    CNTF Stimulates Muscle Glucose Uptake by a PI3-Kinase Dependent Pathway that is Impaired with Obesity.
    Diabetes. 2009.
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53. HWANG JH , Kim DW, Jo EJ, Kim YK, et al
    Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice.
    Diabetes. 2009.
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54. AHMADIAN M , Duncan RE, Varady KA, Frasson D, et al
    Adipose Overexpression of Desnutrin Promotes Fatty Acid Utilization and Attenuates Diet-induced Obesity.
    Diabetes. 2009.
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55. STIMSON RH , Andersson J, Andrew R, Redhead DN, et al
    Cortisol release from adipose tissue by 11beta-hydroxysteroid dehydrogenase type 1 in humans.
    Diabetes. 2009;58:46-53.
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56. RIBEL-MADSEN R , Friedrichsen M, Vaag A, Poulsen P, et al
    Retinol-binding protein 4 in twins: regulatory mechanisms and impact of circulating and tissue expression levels on insulin secretion and action.
    Diabetes. 2009;58:54-60.
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57. XU J , Lloyd DJ, Hale C, Stanislaus S, et al
    Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.
    Diabetes. 2009;58:250-9.
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58. HITTEL DS , Berggren JR, Shearer J, Boyle K, et al
    Increased secretion and expression of myostatin in skeletal muscle from extremely obese women.
    Diabetes. 2009;58:30-8.
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    December 2008
59. HALLSCHMID M , Randeva H, Tan BK, Kern W, et al
    Relationship of Cerebrospinal Fluid Visfatin (PBEF/Nampt) Levels to Adiposity in Humans.
    Diabetes. 2008.
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60. PASARICA M , Sereda OR, Redman LM, Albarado DC, et al
    Reduced Adipose Tissue Oxygenation in Human Obesity - Evidence for Rarefaction, Macrophage Chemotaxis and Inflammation without an Angiogenic Response.
    Diabetes. 2008.
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61. ZOBEL DP , Andreasen CH, Grarup N, Eiberg H, et al
    Variants near MC4R associate with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.
    Diabetes. 2008.
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62. TFAYLI H , Bacha F, Gungor N, Arslanian S, et al
    Phenotypic Type 2 Diabetes in Obese Youth: Insulin Sensitivity and Secretion in Islet-cell Antibody Negative vs. Antibody Positive Patients.
    Diabetes. 2008.
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63. TIMPSON NJ , Lindgren CM, Weedon MN, Randall J, et al
    Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data.
    Diabetes. 2008.
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64. KRAKOFF J , Ma L, Kobes S, Knowler WC, et al
    Lower metabolic rate in individuals heterozygous for either a frameshift or a functional missense MC4R variant.
    Diabetes. 2008;57:3267-72.
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65. BARATTA R , Rossetti P, Prudente S, Barbetti F, et al
    Role of the ENPP1 K121Q polymorphism in glucose homeostasis.
    Diabetes. 2008;57:3360-4.
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    November 2008
66. JIMENEZ-CHILLARON JC , Isganaitis E, Charalambous M, Gesta S, et al
    Intergenerational Transmission of Glucose Intolerance and Obesity by In Utero Undernutrition in Mice.
    Diabetes. 2008.
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67. ORTEGA E , Xu X, Koska J, Marie Francisco A, et al
    Macrophage content in subcutaneous adipose tissue: associations with adiposity, age, inflammatory markers, and whole-body insulin action in healthy Pima Indians.
    Diabetes. 2008.
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68. HAUS JM , Kashyap SR, Kasumov T, Zhang R, et al
    Plasma Ceramides Are Elevated in Obese Subjects with Type 2 Diabetes and Correlate with the Severity of Insulin Resistance.
    Diabetes. 2008.
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69. O'RAHILLY S , Farooqi IS
    Human obesity: a heritable neurobehavioral disorder that is highly sensitive to environmental conditions.
    Diabetes. 2008;57:2905-10.
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70. NEGRAO MR , Monteiro R, Calhau C, Soares R, et al
    Comment on: Hosogai et al. (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56:901-911, 2007.
    Diabetes. 2008;57:e15.
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71. NOGUEIRAS R , Veyrat-Durebex C, Suchanek PM, Klein M, et al
    Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats.
    Diabetes. 2008;57:2977-91.
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    October 2008
72. BERTOLA A , Deveaux V, Bonnafous S, Rousseau D, et al
    Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity.
    Diabetes. 2008.
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73. LIEB W , Pencina MJ, Lanier KJ, Tofler GH, et al
    Association of Parental Obesity with Concentrations of Select Systemic Biomarkers in Non-obese Offspring: The Framingham Heart Study.
    Diabetes. 2008.
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74. BASU R , Basu A, Grudzien M, Jung P, et al
    The Liver is the Site of Splanchnic Cortisol Production in Obese Non-diabetic Humans.
    Diabetes. 2008.
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75. JIAO P , Chen Q, Shah S, Du J, et al
    Obesity-related Upregulation of Monocyte Chemotactic Factors in Adipocytes: Involvement of NF-{kappa} B and JNK Pathways.
    Diabetes. 2008.
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76. VILLENA JA , Choi CS, Wang Y, Kim S, et al
    Resistance to high fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing Pref-1: a new model of partial lipodystrophy.
    Diabetes. 2008.
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77. LEDOUX S , Queguiner I, Msika S, Calderari S, et al
    Angiogenesis Associated with Visceral and Subcutaneous Adipose Tissue in Severe Human Obesity.
    Diabetes. 2008.
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78. LUMENG CN , Delproposto JB, Westcott DJ, Saltiel AR, et al
    Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes.
    Diabetes. 2008.
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79. TOMLINSON JW , Finney J, Gay C, Hughes BA, et al
    Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity.
    Diabetes. 2008;57:2652-60.
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80. REYNA SM , Ghosh S, Tantiwong P, Meka CS, et al
    Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.
    Diabetes. 2008;57:2595-602.
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    September 2008
81. WILLIAMS K , Tchernof A, Hunt KJ, Wagenknecht LE, et al
    Diabetes, abdominal adiposity, and atherogenic dyslipoproteinemia in women compared to men.
    Diabetes. 2008.
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82. HENZE A , Frey SK, Raila J, Tepel M, et al
    Evidence that kidney function but not type 2 diabetes mellitus determines retinol-binding protein 4 (RBP4) serum levels.
    Diabetes. 2008.
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83. BODEN G , Duan X, Homko C, Molina EJ, et al
    Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals.
    Diabetes. 2008;57:2438-44.
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84. STUTZMANN F , Tan K, Vatin V, Dina C, et al
    Prevalence of melanocortin-4 receptor deficiency in Europeans and their age-dependent penetrance in multigenerational pedigrees.
    Diabetes. 2008;57:2511-8.
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85. KEBEDE M , Alquier T, Latour MG, Semache M, et al
    The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding.
    Diabetes. 2008;57:2432-7.
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    August 2008
86. JOY ESPIRITU D , Mazzone T
    Oxidative stress regulates adipocyte apolipoprotein E and suppresses its expression in obesity.
    Diabetes. 2008.
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87. GORAN MI , Lane C, Toledo-Corral C, Weigensberg MJ, et al
    Persistence of Pre-Diabetes in Overweight and Obese Hispanic Children: Association With Progressive Insulin Resistance, Poor Beta-cell Function and Increasing Visceral Fat.
    Diabetes. 2008.
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88. SHEN L , Tso P, Woods SC, Clegg DJ, et al
    Brain apolipoprotein E: an important regulator of food intake in rats.
    Diabetes. 2008;57:2092-8.
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89. TAN CP , Feng Y, Zhou YP, Eiermann GJ, et al
    Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice.
    Diabetes. 2008;57:2211-9.
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90. DALLAIRE P , Bellmann K, Laplante M, Gelinas S, et al
    Obese mice lacking inducible nitric oxide synthase are sensitized to the metabolic actions of peroxisome proliferator-activated receptor-gamma agonism.
    Diabetes. 2008;57:1999-2011.
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    July 2008
91. QI L , Kang K, Zhang C, van Dam RM, et al
    FTO Gene Variant Is Associated with Obesity: Longitudinal Analyses in Two Cohort Studies and Functional Test.
    Diabetes. 2008.
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92. TAN JT , Dorajoo R, Seielstad M, Sim X, et al
    FTO variants are associated with obesity in the Chinese and Malay populations in Singapore.
    Diabetes. 2008;.
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93. NISWENDER KD , Beech BM
    Obesity: increasing awareness of novel environmental factors.
    Diabetes. 2008;57:1786-7.
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94. COHEN DA
    Neurophysiological pathways to obesity: below awareness and beyond individual control.
    Diabetes. 2008;57:1768-73.
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95. LEVINE JA , Davis RM
    The Pol-e-pill finally arrives.
    Diabetes. 2008;57:1784-5.
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96. PICHA KM , Cunningham MR, Drucker DJ, Mathur A, et al
    Protein engineering strategies for sustained glucagon-like peptide-1 receptor-dependent control of glucose homeostasis.
    Diabetes. 2008;57:1926-34.
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97. JOCKEN JW , Roepstorff C, Goossens GH, van der Baan P, et al
    Hormone-sensitive lipase serine phosphorylation and glycerol exchange across skeletal muscle in lean and obese subjects: effect of beta-adrenergic stimulation.
    Diabetes. 2008;57:1834-41.
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    June 2008
98. MZHAVIA N , Yu S, Ikeda S, Chu TT, et al
    Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice.
    Diabetes. 2008;.
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99. MAIER C , Riedl M, Vila G, Nowotny P, et al
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