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The Medical Article of the Year 2008:
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78.
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Articles published in Blood

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Single Articles


    July 2008
  1. PEPPER C , Lin TT, Pratt G, Hewamana S, et al
    Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  2. MATSUSHITA K , Margulies I, Onda M, Nagata S, et al
    Soluble CD22 as a tumor marker for hairy cell leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


    June 2008
  3. QUINTARELLI C , Dotti G, De Angelis B, Hoyos V, et al
    Cytotoxic T lymphocytes directed to the Preferentially Expressed Antigen of Melanoma (PRAME) target chronic myeloid leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  4. RAO R , Fiskus W, Yang Y, Lee P, et al
    HDAC6 inhibition enhances 17-AAG-mediated abrogation of hsp90 chaperone function in human leukemia cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  5. RASSENTI LZ , Jain S, Keating MJ, Wierda WG, et al
    Relative value Of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  6. BALAKRISHNAN K , Wierda WG, Keating MJ, Gandhi V, et al
    Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  7. WHITMAN SP , Hackanson B, Liyanarachchi S, Liu S, et al
    DNA hypermethylation and epigenetic silencing of the tumor suppressor gene SLC5A8 in acute myeloid leukemia with the MLL partial tandem duplication.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  8. FADERL S , Ravandi F, Huang X, Garcia-Manero G, et al
    A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as frontline therapy for patients age >= 60 years with acute myeloid leukemia and high-risk myelodysplastic syndrome.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  9. MOHTY M , Szydlo RM, Yong AS, Apperley JF, et al
    Association between BMI-1 expression, acute graft-versus-host disease and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  10. LIN JH , Kim EJ, Bansal A, Seykora J, et al
    Clinical and in vitro resistance to bexarotene in adult T cell leukemia: loss of RXR-alpha receptor.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  11. FUNK RK , Maxwell TJ, Izumi M, Edwin D, et al
    Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  12. VELDURTHY A , Patz M, Hagist S, Pallasch CP, et al
    The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  13. TEACHEY DT , Sheen C, Hall J, Ryan T, et al
    mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia (ALL).
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  14. YAMADA Y , Sanchez-Aguilera A, Brandt EB, McBride M, et al
    FIP1L1/PDGFR{alpha} synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  15. SALLMYR A , Tomkinson AE, Rassool FV
    Up-regulation of WRN and DNA ligase III{alpha} in chronic myeloid leukemia: consequences for the repair of DNA double strand breaks.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  16. DULUCQ S , Bouchet S, Turcq B, Lippert E, et al
    Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  17. KROEGER H , Jelinek J, Estecio MR, He R, et al
    Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  18. TAUSSIG DC , Miraki-Moud F, Anjos-Afonso F, Pearce DJ, et al
    Anti-CD38 antibody mediated clearance of human repopulating cells masks the heterogeneity of leukemia initiating cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  19. TONINO SH , Spijker R, Luijks DM, van Oers MH, et al
    No convincing evidence for a role of CD31-CD38 interactions in the pathogenesis of chronic lymphocytic leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  20. LAPORT GG , Alvarnas JC, Palmer JM, Snyder DS, et al
    Long-term remission of Philadelphia chromosome positive acute lymphoblastic leukemia following allogeneic hematopoietic cell transplantation from matched sibling donors: a 20-year experience with the fractionated total body irradiation-etoposide regimen.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  21. CHEN CI , Maecker HT, Lee PP
    Development and dynamics of robust T-cell responses to CML under imatinib treatment.
    Blood. 2008;111:5342-9.
    PubMed     Related articles    Abstract available


    May 2008
  22. PAUGH SW , Paugh BS, Rahmani M, Kapitonov D, et al
    A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  23. DAI Y , Chen S, Venditti CA, Pei XY, et al
    Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  24. STOCK W , La M, Sanford B, Bloomfield CD, et al
    What determines the outcomes for adolescents and young adults with acute lymphoblastic leukemia treated on cooperative group protocols? A comparison of children's cancer group and cancer and leukemia group b studies.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  25. MAO X , Liang SB, Hurren R, Gronda M, et al
    Cyproheptadine displays preclinical activity in myeloma and leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  26. LUQMAN M , Klabunde S, Lin K, Georgakis GV, et al
    The anti-leukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  27. GARCIA-MANERO G , Assouline S, Cortes J, Estrov Z, et al
    Phase I study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  28. TAM CS , Kantarjian H, Garcia-Manero G, Borthakur G, et al
    Failure to achieve a major cytogenetic response by twelve months defines inadequate response in patients receiving nilotinib or dasatinib as second or subsequent line therapy for chronic myeloid leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  29. RAGHAVAN M , Smith LL, Lillington DM, Chaplin T, et al
    Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  30. GUARINI A , Chiaretti S, Tavolaro S, Maggio R, et al
    BCR-ligation induced by IgM stimulation results in gene expression and functional changes only in IgVH unmutated chronic lymphocytic leukemia (CLL) cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  31. SHINAWI M , Erez A, Shardy DL, Lee B, et al
    Syndromic thrombocytopenia and predisposition to acute myelogenous leukemia caused by constitutional microdeletions on chromosome 21q.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  32. SHAH MV , Zhang R, Irby R, Kothapalli R, et al
    Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  33. PORKKA K , Koskenvesa P, Lundan T, Rimpilainen J, et al
    Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  34. HIDAKA T , Nakahata S, Hatakeyama K, Hamasaki M, et al
    Down-regulation of TCF8 is involved in the leukemogenesis of adult-T cell leukemia/lymphoma.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  35. CROSS NC
    Hitchhikers' guide to the leukemia genome.
    Blood. 2008;111:4428-9.
    PubMed     Related articles   


    April 2008
  36. KUJAWSKI L , Ouillette P, Erba H, Saddler C, et al
    Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  37. ELLIS NA , Huo D, Yildiz O, Worrillow LJ, et al
    MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  38. CROWTHER D , Wild R, Sellick G, Dyer MJ, et al
    Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  39. AYDIN S , Rossi D, Bergui L, D'Arena G, et al
    CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter's syndrome?
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  40. BLAKE SJ , Bruce Lyons A, Fraser CK, Hayball JD, et al
    Dasatinib suppresses in vitro natural killer cell cytotoxicity.
    Blood. 2008;111:4415-6.
    PubMed     Related articles   


  41. PAPAYANNOPOULOU T , Scadden DT
    Stem-cell ecology and stem cells in motion.
    Blood. 2008;111:3923-30.
    PubMed     Related articles    Abstract available


  42. GONTAREWICZ A , Balabanov S, Keller G, Colombo R, et al
    Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I.
    Blood. 2008;111:4355-64.
    PubMed     Related articles    Abstract available


  43. DAYYANI F , Wang J, Yeh JR, Ahn EY, et al
    Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.
    Blood. 2008;111:4338-47.
    PubMed     Related articles    Abstract available


  44. WATANABE-OKOCHI N , Kitaura J, Ono R, Harada H, et al
    AML1 mutations induced MDS and MDS/AML in a mouse BMT model.
    Blood. 2008;111:4297-308.
    PubMed     Related articles    Abstract available


  45. TAM CS , O'Brien S, Wierda W, Kantarjian H, et al
    Long term results of the fludarabine, cyclophosphamide & rituximab regimen as initial therapy of chronic lymphocytic leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  46. JABBOUR E , Kantarjian H, Jones D, Breeden M, et al
    Characteristics and outcome of patients with chronic myeloid leukemia and T315I mutation following failure of imatinib mesylate therapy.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  47. MARKS DI , Perez WS, He W, Zhang MJ, et al
    Unrelated donor transplants in adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  48. JANKOVIC D , Gorello P, Liu T, Ehret S, et al
    Leukemogenic mechanisms and targets of NUP98/HHEX fusion in acute myeloid leukemia (AML).
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  49. BOROWITZ MJ , Devidas M, Hunger SP, Bowman WP, et al
    Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: A Children's Oncology Group study.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  50. WIMMER-KLEIKAMP SH , Nievergall E, Gegenbauer K, Adikari S, et al
    Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  51. HAMADANI M , Awan FT, Devine SM
    The impact of HMG-CoA reductase inhibition on the incidence and severity of graft-versus-host disease in patients with acute leukemia undergoing allogeneic transplantation.
    Blood. 2008;111:3901-2.
    PubMed     Related articles   


  52. MA W , Kantarjian H, Zhang X, Sun W, et al
    Higher detection rate of JAK2 mutation using plasma.
    Blood. 2008;111:3906-7.
    PubMed     Related articles   



  53. Chronic leukocytosis.
    Blood. 2008;111:3908.
    PubMed     Related articles   


  54. LI L , Piloto O, Nguyen HB, Greenberg K, et al
    Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.
    Blood. 2008;111:3849-58.
    PubMed     Related articles    Abstract available


  55. DE GORTER DJ , Reijmers RM, Beuling EA, Naber HP, et al
    The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells.
    Blood. 2008;111:3364-72.
    PubMed     Related articles    Abstract available


  56. MATTE-MARTONE C , Liu J, Jain D, McNiff J, et al
    CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL.
    Blood. 2008;111:3884-92.
    PubMed     Related articles    Abstract available


  57. MARAFIOTI T , Paterson JC, Ballabio E, Reichard KK, et al
    Novel markers of normal and neoplastic human plasmacytoid dendritic cells.
    Blood. 2008;111:3778-92.
    PubMed     Related articles    Abstract available


  58. HARB JG , Chyla BI, Huettner CS
    Loss of Bcl-x in Ph+ B-ALL increases cellular proliferation and does not inhibit leukemogenesis.
    Blood. 2008;111:3760-9.
    PubMed     Related articles    Abstract available


  59. SPORTOLETTI P , Grisendi S, Majid SM, Cheng K, et al
    Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.
    Blood. 2008;111:3859-62.
    PubMed     Related articles    Abstract available


  60. ROCHE-LESTIENNE C , Deluche L, Corm S, Tigaud I, et al
    RUNX1 DNA-binding mutations and RUNX1-PRDM16 cryptic fusions in BCR-ABL+ leukemias are frequently associated with secondary trisomy 21 and may contribute to clonal evolution and imatinib resistance.
    Blood. 2008;111:3735-41.
    PubMed     Related articles    Abstract available


  61. RUSHWORTH SA , MacEwan DJ
    HO-1 underlies resistance of AML cells to TNF-induced apoptosis.
    Blood. 2008;111:3793-801.
    PubMed     Related articles    Abstract available


  62. CARTER BZ , Mak DH, Schober WD, Dietrich MF, et al
    Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.
    Blood. 2008;111:3742-50.
    PubMed     Related articles    Abstract available


  63. WEISBERG E , Banerji L, Wright RD, Barrett R, et al
    Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL- and mutant FLT3-expressing cells.
    Blood. 2008;111:3723-34.
    PubMed     Related articles    Abstract available


  64. DULUCQ S , St-Onge G, Gagne V, Ansari M, et al
    DNA variants in the dihydrofolate reductase gene and outcome in childhood ALL.
    Blood. 2008;111:3692-700.
    PubMed     Related articles    Abstract available


    March 2008
  65. LANGER C , Radmacher MD, Ruppert AS, Whitman SP, et al
    High BAALC expression associates with other molecular prognostic markers, poor outcome and a distinct gene-expression signature in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  66. SCUTO A , Kirschbaum M, Kowolik C, Kretzner L, et al
    The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph- acute lymphoblastic leukemia cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  67. KITADA S , Kress CL, Krajewska M, Jia L, et al
    Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).
    Blood. 2008;111:3211-9.
    PubMed     Related articles    Abstract available


  68. SALLMYR A , Fan J, Datta K, Kim KT, et al
    Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML.
    Blood. 2008;111:3173-82.
    PubMed     Related articles    Abstract available


  69. MONNI R , Haddaoui L, Naba A, Gallais I, et al
    Ezrin is a target for oncogenic Kit mutants in murine erythroleukemia.
    Blood. 2008;111:3163-72.
    PubMed     Related articles    Abstract available


  70. CHEN YY , Malik M, Tomkowicz BE, Collman RG, et al
    BCR-ABL1 alters SDF-1{alpha} mediated adhesive responses through the {beta}2 integrin LFA-1 in leukemia cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  71. CHEN J , Petrus M, Bryant BR, Nguyen VP, et al
    Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  72. JONGEN-LAVRENCIC M , Sun SM, Dijkstra MK, Valk PJ, et al
    MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  73. FERRAJOLI A , Lee BN, Schlette EJ, O'Brien SM, et al
    Lenalidomide induces complete and partial remissions in patients with relapsed and refractory chronic lymphocytic leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  74. MODY R , Li S, Dover DC, Sallan S, et al
    Twenty five year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  75. PATTEN PE , Buggins AG, Richards J, Wotherspoon A, et al
    CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  76. GHIA EM , Jain S, Widhopf GF, Rassenti LZ, et al
    Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal-center leukemogenic selection.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  77. WALTER RB , Boyle KM, Appelbaum FR, Bernstein ID, et al
    Simultaneously targeting CD45 significantly increases cytotoxicity of the anti-CD33 immunoconjugate, gemtuzumab ozogamicin, against acute myeloid leukemia (AML) cells and improves survival of mice bearing human AML xenografts.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  78. WANG ZY , Chen Z
    Acute promyelocytic leukemia: from highly fatal to highly curable.
    Blood. 2008;111:2505-15.
    PubMed     Related articles    Abstract available


  79. MEYER LH , Queudeville M, Eckhoff SM, Creutzig U, et al
    Intact apoptosis signaling in myeloid leukemia cells determines treatment outcome in childhood AML.
    Blood. 2008;111:2899-903.
    PubMed     Related articles    Abstract available


  80. FITTER S , Dewar AL, Kostakis P, To LB, et al
    Long-term imatinib therapy promotes bone formation in CML patients.
    Blood. 2008;111:2538-47.
    PubMed     Related articles    Abstract available


  81. HOEMME C , Peerzada A, Behre G, Wang Y, et al
    Chromatin modifications induced by PML-RARalpha repress critical targets in leukemogenesis as analyzed by ChIP-Chip.
    Blood. 2008;111:2887-95.
    PubMed     Related articles    Abstract available


  82. BACHER U , Haferlach C, Kern W, Haferlach T, et al
    Prognostic relevance of FLT3-TKD mutations in AML: the combination matters--an analysis of 3082 patients.
    Blood. 2008;111:2527-37.
    PubMed     Related articles    Abstract available


    February 2008
  83. NISHIOKA C , Ikezoe T, Yang J, Miwa A, et al
    Ki11502, a novel multi-targeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  84. BRENNER H , Gondos A, Pulte D
    Trends in long-term survival of patients with chronic lymphocytic leukemia from the 1980s to the early 21st century.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  85. SAITOH Y , Yamamoto N, Dewan MZ, Sugimoto H, et al
    Overexpressed NF-{kappa}B inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  86. HASSANE DC , Guzman ML, Corbett C, Li X, et al
    Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  87. LI FJ , Ding S, Pan J, Shakhmatov MA, et al
    FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  88. VAN VLIERBERGHE P , van Grotel M, Tchinda J, Lee C, et al
    The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  89. FRENCH D , Hamilton LH, Mattano LA Jr, Sather HN, et al
    A PAI-1 (SERPINE1) polymorphism predicts osteonecrosis in children with acute lymphoblastic leukemia: a report from the Children's Oncology Group.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  90. MORICKE A , Reiter A, Zimmermann M, Gadner H, et al
    Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  91. VYAS P , Crispino J
    Response: JAK mutations in Down syndrome-associated transient myeloproliferative disorder and acute megakaryocytic leukemia.
    Blood. 2008;111:2493.
    PubMed     Related articles   


  92. HAMA A , Yagasaki H, Takahashi Y, Matsumoto K, et al
    Response: Mutations of JAK2, JAK3 and GATA1 in acute megakaryoblastic leukemia of Down syndrome.
    Blood. 2008;111:2493-4.
    PubMed     Related articles   


  93. FLOTHO C , Coustan-Smith E, Pei D, Cheng C, et al
    Response: Genes associated with response to therapy in childhood acute lymphoblastic leukemia.
    Blood. 2008;111:2487-8.
    PubMed     Related articles   


  94. CATCHPOOLE D , Guo D, Jiang H, Biesheuvel C, et al
    Predicting outcome in childhood acute lymphoblastic leukemia using gene expression profiling: Prognostication or protocol selection?
    Blood. 2008;111:2486-7.
    PubMed     Related articles   


  95. BAUMANN S , Fas SC, Giaisi M, Muller WW, et al
    Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis.
    Blood. 2008;111:2354-63.
    PubMed     Related articles    Abstract available


  96. ENDERSBY R , Majewski IJ, Winteringham L, Beaumont JG, et al
    Hls5 regulated erythroid differentiation by modulating GATA-1 activity.
    Blood. 2008;111:1946-50.
    PubMed     Related articles    Abstract available


  97. MORETTI S , Procopio A, Lazzarini R, Rippo MR, et al
    Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts.
    Blood. 2008;111:2290-9.
    PubMed     Related articles    Abstract available


  98. TAILOR P , Tamura T, Morse HC 3rd, Ozato K, et al
    The BXH2 mutation in IRF8 differentially impairs dendritic cell subset development in the mouse.
    Blood. 2008;111:1942-5.
    PubMed     Related articles    Abstract available


  99. LEVINE JE , Paczesny S, Mineishi S, Braun T, et al
    Etanercept plus methylprednisolone as initial therapy for acute graft-versus-host disease.
    Blood. 2008;111:2470-5.
    PubMed     Related articles    Abstract available


  100. PETIT I , Karajannis MA, Vincent L, Young L, et al
    The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
    Blood. 2008;111:1951-61.
    PubMed     Related articles    Abstract available


  101. KHORASHAD JS , Milojkovic D, Mehta P, Anand M, et al
    In vivo kinetics of kinase domain mutations in CML patients treated with dasatinib after failing imatinib.
    Blood. 2008;111:2378-81.
    PubMed     Related articles    Abstract available


  102. BOEHRER S , Ades L, Braun T, Galluzzi L, et al
    Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study.
    Blood. 2008;111:2170-80.
    PubMed     Related articles    Abstract available


  103. LUGTHART S , Drunen EV, Norden YV, Hoven AV, et al
    High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  104. TOMASSON MH , Xiang Z, Walgren R, Zhao Y, et al
    Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  105. LARSON RA , Druker BJ, Guilhot FA, O'Brien SG, et al
    Imatinib pharmacokinetics and its correlation with response and safety in chronic phase chronic myeloid leukemia: a subanalysis of the IRIS study.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  106. LORIAUX MM , Levine RL, Tyner JW, Frohling S, et al
    High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia.
    Blood. 2008;.
    PubMed     Related articles    Abstract available


  107. GIANFALDONI G , Mannelli F, Bencini S, Leoni F, et al
    Peripheral blood blast clearance during induction therapy in acute myeloid leukemia.
    Blood. 2008;111:1746-7.
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