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  Bacterial Infections and Mycoses

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Articles published in J Med Chem

Retrieve available abstracts of 26 articles:
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Single Articles


    September 2017
  1. NI S, Wei H, Li B, Chen F, et al
    Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant and Vancomycin-Intermediate Staphylococcus aureus Infections in vivo.
    J Med Chem. 2017 Sep 7. doi: 10.1021/acs.jmedchem.7b00949.
    PubMed     Text format     Abstract available


    July 2017
  2. KOZIKOWSKI AP, Onajole OK, Stec J, Dupont C, et al
    Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections.
    J Med Chem. 2017;60:5876-5888.
    PubMed     Text format     Abstract available


    June 2017
  3. PIIZZI G, Parker DT, Peng Y, Dobler M, et al
    Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
    J Med Chem. 2017;60:5002-5014.
    PubMed     Text format     Abstract available


  4. LIN S, Koh JJ, Aung TT, Sin WLW, et al
    Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2017 Jun 21. doi: 10.1021/acs.jmedchem.7b00380.
    PubMed     Text format     Abstract available


  5. LIU F, Dawadi S, Maize KM, Dai R, et al
    Structure-Based Optimization of Pyridoxal 5'-Phosphate (PLP)-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
    J Med Chem. 2017 Jun 8. doi: 10.1021/acs.jmedchem.7b00189.
    PubMed     Text format     Abstract available


    May 2017
  6. PANCHAUD P, Bruyere T, Blumstein AC, Bur D, et al
    Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
    J Med Chem. 2017;60:3755-3775.
    PubMed     Text format     Abstract available


  7. BHOWMICK M, Tokmina-Roszyk D, Onwuha-Ekpete L, Harmon K, et al
    Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.
    J Med Chem. 2017;60:3814-3827.
    PubMed     Text format     Abstract available


  8. MAYER K, Eris D, Schwardt O, Sager CP, et al
    Urinary Tract Infection - Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant?
    J Med Chem. 2017 May 4. doi: 10.1021/acs.jmedchem.7b00342.
    PubMed     Text format     Abstract available


    April 2017
  9. HAGRAS M, Mohammad H, Mandour MS, Hegazy YA, et al
    Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA).
    J Med Chem. 2017 Apr 24. doi: 10.1021/acs.jmedchem.7b00392.
    PubMed     Text format     Abstract available


  10. SIRICILLA S, Mitachi K, Yang J, Eslamimehr S, et al
    A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii.
    J Med Chem. 2017;60:2869-2878.
    PubMed     Text format     Abstract available


  11. YANG T, Moreira W, Nyantakyi SA, Chen H, et al
    Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties.
    J Med Chem. 2017;60:2745-2763.
    PubMed     Text format     Abstract available


  12. TAN L, Tao Y, Wang T, Zou F, et al
    Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
    J Med Chem. 2017;60:2669-2684.
    PubMed     Text format     Abstract available


    March 2017
  13. DENG Y, Sun C, Hunt DK, Fyfe C, et al
    Heterocyclyl Tetracyclines. 1. 7-Trifluoromethyl-8-Pyrrolidinyltetracyclines: Potent, Broad Spectrum Antibacterial Agents with Enhanced Activity against Pseudomonas aeruginosa.
    J Med Chem. 2017;60:2498-2512.
    PubMed     Text format     Abstract available


  14. DOU X, Zhu X, Wang J, Dong N, et al
    Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
    J Med Chem. 2017;60:2257-2270.
    PubMed     Text format     Abstract available


  15. HONG WD, Gibbons PD, Leung SC, Amewu R, et al
    Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.
    J Med Chem. 2017 Mar 17. doi: 10.1021/acs.jmedchem.6b01718.
    PubMed     Text format     Abstract available


  16. MOHAMMAD H, Younis W, Chen L, Peters CE, et al
    Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity In Vitro and In Vivo against Vancomycin-resistant Enterococci.
    J Med Chem. 2017 Mar 1. doi: 10.1021/acs.jmedchem.6b01780.
    PubMed     Text format     Abstract available


    February 2017
  17. TOLEDANO-MAGANA Y, Garcia-Ramos JC, Torres-Gutierrez C, Vazquez-Gasser C, et al
    Water-Soluble Ruthenium (II) Chiral Heteroleptic Complexes with Amoebicidal in Vitro and in Vivo Activity.
    J Med Chem. 2017;60:899-912.
    PubMed     Text format     Abstract available


  18. ASTOLFI A, Felicetti T, Iraci N, Manfroni G, et al
    Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.
    J Med Chem. 2017 Feb 8. doi: 10.1021/acs.jmedchem.6b01439.
    PubMed     Text format     Abstract available


    December 2016
  19. STULAR T, Lesnik S, Rozman K, Schink J, et al
    Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


  20. GARZAN A, Willby MJ, Green KD, Gajadeera CS, et al
    Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.
    J Med Chem. 2016;59:10619-10628.
    PubMed     Text format     Abstract available


    September 2016
  21. GORDON CP, Olson SD, Lister JL, Kavanaugh JS, et al
    Truncated auto-inducing peptides as antagonists of Staphylococcus lugdunensis quorum sensing.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


    July 2016
  22. BRUNNER K, Maric S, Reshma RS, Almqvist H, et al
    Inhibitors of the cysteine synthase CysM with antibacterial potency against dormant Mycobacterium tuberculosis.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


    June 2016
  23. PITTA E, Rogacki MK, Balabon O, Huss S, et al
    Searching for new leads for Tuberculosis: Design, synthesis and biological evaluation of novel 2-quinolin-4-yloxyacetamides.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


  24. BARANOWSKI C, Rubin EJ
    Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park?
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


  25. STEC J, Onajole OK, Lun S, Guo H, et al
    Indole-2-carboxamide-Based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


    May 2016
  26. YU M, Nagalingam G, Ellis S, Martinez E, et al
    Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis.
    J Med Chem. 2016.
    PubMed     Text format     Abstract available


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