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	The Medical Article of the Year 2008: Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78. Free full-text

Bacterial Infections and Mycoses

Free Subscription Articles published in J Med Chem Retrieve available abstracts of 20 articles: HTML format

Single Articles

June 2008
1. SABATINI S , Kaatz GW, Rossolini GM, Brandini D, et al
   From Phenothiazine to 3-Phenyl-1,4-benzothiazine Derivatives as Inhibitors of the Staphylococcus aureus NorA Multidrug Efflux Pump.
   J Med Chem. 2008;.
   PubMed     Related articles    Abstract available
   
   
   
2. LA REGINA G , D'Auria FD, Tafi A, Piscitelli F, et al
   1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, New Imidazoles with Potent Activity against Candida albicans and Dermatophytes. Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies.
   J Med Chem. 2008;.
   PubMed     Related articles    Abstract available
   
   
   April 2008
3. BRICKNER SJ , Barbachyn MR, Hutchinson DK, Manninen PR, et al
   Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.
   J Med Chem. 2008;51:1981-90.
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4. HIROKAWA Y , Kinoshita H, Tanaka T, Nakata K, et al
   Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens.
   J Med Chem. 2008;51:1991-4.
   PubMed     Related articles    Abstract available
   
   
   
5. GUTIERREZ-LUGO MT , Bewley CA
   Natural Products, Small Molecules, and Genetics in Tuberculosis Drug Development.
   J Med Chem. 2008;.
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   March 2008
6. VELAPARTHI S , Brunsteiner M, Uddin R, Wan B, et al
   5-tert-Butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs.
   J Med Chem. 2008;.
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   February 2008
7. SIMERSKA P , Abdel-Aal AB, Fujita Y, Moyle PM, et al
   Development of a Liposaccharide-Based Delivery System and Its Application to the Design of Group A Streptococcal Vaccines.
   J Med Chem. 2008;.
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   December 2007
8. ABDEL-AAL AB , Batzloff MR, Fujita Y, Barozzi N, et al
   Structure-Activity Relationship of a Series of Synthetic Lipopeptide Self-Adjuvanting Group A Streptococcal Vaccine Candidates.
   J Med Chem. 2007;.
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   November 2007
9. POEL TJ , Thomas RC, Adams WJ, Aristoff PA, et al
   Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.
   J Med Chem. 2007;50:5886-9.
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10. ANTHONY NG , Breen D, Clarke J, Donoghue G, et al
    Antimicrobial lexitropsins containing amide, amidine, and alkene linking groups.
    J Med Chem. 2007;50:6116-25.
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11. METAFERIA BB , Fetterolf BJ, Shazad-Ul-Hussan S, Moravec M, et al
    Synthesis of Natural Product-Inspired Inhibitors of Mycobacterium tuberculosis Mycothiol-Associated Enzymes: The First Inhibitors of GlcNAc-Ins Deacetylase.
    J Med Chem. 2007;.
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12. YAO B , Ji H, Cao Y, Zhou Y, et al
    Synthesis and antifungal activities of novel 2-aminotetralin derivatives.
    J Med Chem. 2007;50:5293-300.
    PubMed     Related articles    Abstract available
    
    
    October 2007
13. RECK F , Zhou F, Eyermann CJ, Kern G, et al
    Novel substituted (pyridin-3-yl)phenyloxazolidinones: antibacterial agents with reduced activity against monoamine oxidase A and increased solubility.
    J Med Chem. 2007;50:4868-81.
    PubMed     Related articles    Abstract available
    
    
    September 2007
14. SHILABIN AG , Kasanah N, Wedge DE, Hamann MT, et al
    Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies.
    J Med Chem. 2007;50:4340-50.
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    August 2007
15. HU X , Prehna G, Stebbins CE
    Targeting plague virulence factors: a combined machine learning method and multiple conformational virtual screening for the discovery of Yersinia protein kinase A inhibitors.
    J Med Chem. 2007;50:3980-3.
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16. RAI D , Johar M, Srivastav NC, Manning T, et al
    Inhibition of Mycobacterium tuberculosis, Mycobacterium bovis, and Mycobacterium avium by Novel Dideoxy Nucleosides.
    J Med Chem. 2007;.
    PubMed     Related articles    Abstract available
    
    
    July 2007
17. MAPLES KR , Wheeler C, Ip E, Plattner JJ, et al
    Novel semisynthetic derivative of antibiotic Eremomycin active against drug-resistant gram-positive pathogens including Bacillus anthracis.
    J Med Chem. 2007;50:3681-5.
    PubMed     Related articles    Abstract available
    
    
    June 2007
18. JOHAR M , Manning T, Tse C, Desroches N, et al
    Growth Inhibition of Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium In Vitro: Effect of 1-beta-d-2'-Arabinofuranosyl and 1-(2'-Deoxy-2'-fluoro-beta-d-2'-ribofuranosyl) Pyrimidine Nucleoside Analogs.
    J Med Chem. 2007;.
    PubMed     Related articles    Abstract available
    
    
    May 2007
19. HANESSIAN S , Szychowski J, Adhikari SS, Vasquez G, et al
    Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.
    J Med Chem. 2007;50:2352-69.
    PubMed     Related articles    Abstract available
    
    
    April 2007
20. DABIDEEN DR , Cheng KF, Aljabari B, Miller EJ, et al
    Phenolic hydrazones are potent inhibitors of macrophage migration inhibitory factor proinflammatory activity and survival improving agents in sepsis.
    J Med Chem. 2007;50:1993-7.
    PubMed     Related articles    Abstract available
    
    

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