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The Medical Article of the Year 2008:
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78.
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Articles published in Proc Natl Acad Sci U S A

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    June 2008
  1. BURT TD , Agan BK, Marconi VC, He W, et al
    Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE {varepsilon}4/{varepsilon}4 genotype accelerates HIV disease progression.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  2. BOURGEOIS C , Hao Z, Rajewsky K, Potocnik AJ, et al
    Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  3. MCCULLOUGH J , Fisher RD, Whitby FG, Sundquist WI, et al
    ALIX-CHMP4 interactions in the human ESCRT pathway.
    Proc Natl Acad Sci U S A. 2008;105:7687-91.
    PubMed     Related articles    Abstract available


    May 2008
  4. KEELE BF , Giorgi EE, Salazar-Gonzalez JF, Decker JM, et al
    Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available   Free Full Text


    April 2008
  5. READINGER JA , Schiralli GM, Jiang JK, Thomas CJ, et al
    Selective targeting of ITK blocks multiple steps of HIV replication.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available   Free Full Text


  6. MULDER LC , Harari A, Simon V
    Cytidine deamination induced HIV-1 drug resistance.
    Proc Natl Acad Sci U S A. 2008;105:5501-6.
    PubMed     Related articles    Abstract available


  7. ROSE NF , Publicover J, Chattopadhyay A, Rose JK, et al
    Hybrid alphavirus-rhabdovirus propagating replicon particles are versatile and potent vaccine vectors.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


    March 2008
  8. BOBARDT MD , Cheng G, de Witte L, Selvarajah S, et al
    Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  9. SAHAF B , Atkuri K, Heydari K, Malipatlolla M, et al
    Culturing of human peripheral blood cells reveals unsuspected lymphocyte responses relevant to HIV disease.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  10. SEDAGHAT AR , Dinoso JB, Shen L, Wilke CO, et al
    Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle.
    Proc Natl Acad Sci U S A. 2008;105:4832-7.
    PubMed     Related articles    Abstract available


  11. WOROBEY M , Pitchenik AE, Gilbert MT, Wlasiuk G, et al
    Reply to Pape et al.: The phylogeography of HIV-1 group M subtype B.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles   


  12. PALMER S , Maldarelli F, Wiegand A, Bernstein B, et al
    Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy.
    Proc Natl Acad Sci U S A. 2008;105:3879-84.
    PubMed     Related articles    Abstract available   Free Full Text


  13. PAPE JW , Farmer P, Koenig S, Fitzgerald D, et al
    The epidemiology of AIDS in Haiti refutes the claims of Gilbert et al.
    Proc Natl Acad Sci U S A. 2008;105:E13.
    PubMed     Related articles   


  14. FREY G , Peng H, Rits-Volloch S, Morelli M, et al
    A fusion-intermediate state of HIV-1 gp41 targeted by broadly neutralizing antibodies.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  15. RAMESSAR K , Rademacher T, Sack M, Stadlmann J, et al
    Cost-effective production of a vaginal protein microbicide to prevent HIV transmission.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


    February 2008
  16. FIORENTINI S , Riboldi E, Facchetti F, Avolio M, et al
    HIV-1 matrix protein p17 induces human plasmacytoid dendritic cells to acquire a migratory immature cell phenotype.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  17. WANG SK , Liang PH, Astronomo RD, Hsu TL, et al
    Targeting the carbohydrates on HIV-1: Interaction of oligomannose dendrons with human monoclonal antibody 2G12 and DC-SIGN.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  18. CHENG G , Montero A, Gastaminza P, Whitten-Bauer C, et al
    A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  19. WILSON SJ , Webb BL, Ylinen LM, Verschoor E, et al
    Independent evolution of an antiviral TRIMCyp in rhesus macaques.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  20. VIRGEN CA , Kratovac Z, Bieniasz PD, Hatziioannou T, et al
    Independent genesis of chimeric TRIM5-cyclophilin proteins in two primate species.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  21. BRENNAN G , Kozyrev Y, Hu SL
    TRIMCyp expression in Old World primates Macaca nemestrina and Macaca fascicularis.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  22. CORBETT M , Bogers WM, Heeney JL, Gerber S, et al
    Aerosol immunization with NYVAC and MVA vectored vaccines is safe, simple, and immunogenic.
    Proc Natl Acad Sci U S A. 2008;105:2046-51.
    PubMed     Related articles    Abstract available


  23. TRUMPFHELLER C , Caskey M, Nchinda G, Longhi MP, et al
    The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


    January 2008
  24. VIEILLARD V , Le Grand R, Dausset J, Debre P, et al
    A vaccine strategy against AIDS: An HIV gp41 peptide immunization prevents NKp44L expression and CD4+ T cell depletion in SHIV-infected macaques.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  25. DAS K , Bauman JD, Clark AD Jr, Frenkel YV, et al
    High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available   Free Full Text


  26. GOMEZ-GARDENES J , Latora V, Moreno Y, Profumo E, et al
    Spreading of sexually transmitted diseases in heterosexual populations.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  27. BARBETA BL , Marshall AT, Gillon AD, Craik DJ, et al
    Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  28. RYO A , Tsurutani N, Ohba K, Kimura R, et al
    SOCS1 is an inducible host factor during HIV-1 infection and regulates the intracellular trafficking and stability of HIV-1 Gag.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available   Free Full Text


    December 2007
  29. HERCE HD , Garcia AE
    Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


    November 2007
  30. BETZI S , Restouin A, Opi S, Arold ST, et al
    Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  31. FANG C , Bauman JD, Das K, Remorino A, et al
    Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  32. DE WITTE L , Bobardt M, Chatterji U, Degeest G, et al
    Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  33. CHEN HY , Di Mascio M, Perelson AS, Ho DD, et al
    Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  34. HASHIGUCHI T , Kajikawa M, Maita N, Takeda M, et al
    Crystal structure of measles virus hemagglutinin provides insight into effective vaccines.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  35. HOLMES EC
    When HIV spread afar.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles   


  36. BOYER JD , Robinson TM, Kutzler MA, Vansant G, et al
    Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  37. GILBERT MT , Rambaut A, Wlasiuk G, Spira TJ, et al
    The emergence of HIV/AIDS in the Americas and beyond.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


    October 2007
  38. HARDY AW , Graham DR, Shearer GM, Herbeuval JP, et al
    HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulates HIV coreceptors by Toll-like receptor 7-induced IFN-{alpha}
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  39. DEVICO A , Fouts T, Lewis GK, Gallo RC, et al
    Antibodies to CD4-induced sites in HIV gp120 correlate with the control of SHIV challenge in macaques vaccinated with subunit immunogens.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  40. FRASER C , Hollingsworth TD, Chapman R, de Wolf F, et al
    Variation in HIV-1 set-point viral load: Epidemiological analysis and an evolutionary hypothesis.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  41. WELCH BD , Vandemark AP, Heroux A, Hill CP, et al
    Potent D-peptide inhibitors of HIV-1 entry.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  42. BLOOM DE , Canning D
    Mortality traps and the dynamics of health transitions.
    Proc Natl Acad Sci U S A. 2007;104:16044-9.
    PubMed     Related articles    Abstract available


  43. HARARI A , Cellerai C, Bellutti Enders F, Kostler J, et al
    Skewed association of polyfunctional antigen-specific CD8 T cell populations with HLA-B genotype.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


    September 2007
  44. HUITRON-RESENDIZ S , Marcondes MC, Flynn CT, Lanigan CM, et al
    Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


    August 2007
  45. GREGSON S , Nyamukapa C, Lopman B, Mushati P, et al
    Critique of early models of the demographic impact of HIV/AIDS in sub-Saharan Africa based on contemporary empirical data from Zimbabwe.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  46. CLARKE SG
    HIV protease inhibitors and nuclear lamin processing: Getting the right bells and whistles.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles   


  47. MOUSNIER A , Kubat N, Massias-Simon A, Segeral E, et al
    von Hippel Lindau binding protein 1-mediated degradation of integrase affects HIV-1 gene expression at a postintegration step.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  48. BISGROVE DA , Mahmoudi T, Henklein P, Verdin E, et al
    Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  49. AN DS , Donahue RE, Kamata M, Poon B, et al
    Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


    July 2007
  50. COFFINIER C , Hudon SE, Farber EA, Chang SY, et al
    HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  51. DWYER JJ , Wilson KL, Davison DK, Freel SA, et al
    Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  52. HRECKA K , Gierszewska M, Srivastava S, Kozaczkiewicz L, et al
    Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


    June 2007
  53. ZENG Y , Liu HW, Landes CF, Kim YJ, et al
    Probing nucleation, reverse annealing, and chaperone function along the reaction path of HIV-1 single-strand transfer.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


    May 2007
  54. ZHANG PF , Cham F, Dong M, Choudhary A, et al
    Extensively cross-reactive anti-HIV-1 neutralizing antibodies induced by gp140 immunization.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  55. WHITE RG , Cooper BS, Kedhar A, Orroth KK, et al
    Quantifying HIV-1 transmission due to contaminated injections.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  56. BRIDEAU-ANDERSEN AD , Huang X, Sun SC, Chen TT, et al
    Directed evolution of gene-shuffled IFN-{alpha} molecules with activity profiles tailored for treatment of chronic viral diseases.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  57. HAYOUKA Z , Rosenbluh J, Levin A, Loya S, et al
    Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  58. WAHEED AA , Ablan SD, Roser JD, Sowder RC, et al
    HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


    April 2007
  59. SAEZ-CIRION A , Lacabaratz C, Lambotte O, Versmisse P, et al
    HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  60. PIZZATO M , Helander A, Popova E, Calistri A, et al
    Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  61. ASQUITH B , McLean AR
    In vivo CD8+ T cell control of immunodeficiency virus infection in humans and macaques.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


    March 2007
  62. JAMES LC , Keeble AH, Khan Z, Rhodes DA, et al
    Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  63. HANSEN TM , Reihani SN, Oddershede LB, Sorensen MA, et al
    Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  64. KATZOURAKIS A , Tristem M, Pybus OG, Gifford RJ, et al
    Discovery and analysis of the first endogenous lentivirus.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


  65. LIU HW , Zeng Y, Landes CF, Kim YJ, et al
    Insights on the role of nucleic acid/protein interactions in chaperoned nucleic acid rearrangements of HIV-1 reverse transcription.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


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