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The Medical Article of the Year 2008:
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78.
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Articles published in Proc Natl Acad Sci U S A

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    June 2008
  1. ZENG Q , Langereis MA, van Vliet AL, Huizinga EG, et al
    Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  2. ZHENG BJ , Chan KW, Lin YP, Zhao GY, et al
    Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


    May 2008
  3. BELSER JA , Blixt O, Chen LM, Pappas C, et al
    Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility.
    Proc Natl Acad Sci U S A. 2008;105:7558-63.
    PubMed     Related articles    Abstract available   Free Full Text


    April 2008
  4. KASHYAP AK , Steel J, Oner AF, Dillon MA, et al
    Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


    March 2008
  5. GILBERT M , Xiao X, Pfeiffer DU, Epprecht M, et al
    Mapping H5N1 highly pathogenic avian influenza risk in Southeast Asia.
    Proc Natl Acad Sci U S A. 2008;105:4769-74.
    PubMed     Related articles    Abstract available   Free Full Text


  6. JACKSON D , Hossain MJ, Hickman D, Perez DR, et al
    A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available   Free Full Text


  7. HALLORAN ME , Ferguson NM, Eubank S, Longini IM Jr, et al
    Modeling targeted layered containment of an influenza pandemic in the United States.
    Proc Natl Acad Sci U S A. 2008;.
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    February 2008
  8. JOO HM , He Y, Sangster MY
    Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  9. PAPPAS C , Aguilar PV, Basler CF, Solorzano A, et al
    Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus.
    Proc Natl Acad Sci U S A. 2008;.
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  10. SRINIVASAN A , Viswanathan K, Raman R, Chandrasekaran A, et al
    Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses.
    Proc Natl Acad Sci U S A. 2008;.
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    January 2008
  11. CADY SD , Hong M
    Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  12. DOWELL SF , Bresee JS
    Pandemic lessons from Iceland.
    Proc Natl Acad Sci U S A. 2008;105:1109-10.
    PubMed     Related articles   


  13. SONG JH , Nguyen HH, Cuburu N, Horimoto T, et al
    Sublingual vaccination with influenza virus protects mice against lethal viral infection.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available


  14. GOTTFREDSSON M , Halldorsson BV, Jonsson S, Kristjansson M, et al
    Lessons from the past: Familial aggregation analysis of fatal pandemic influenza (Spanish flu) in Iceland in 1918.
    Proc Natl Acad Sci U S A. 2008;.
    PubMed     Related articles    Abstract available   Free Full Text


    December 2007
  15. MA W , Vincent AL, Gramer MR, Brockwell CB, et al
    Identification of H2N3 influenza A viruses from swine in the United States.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


    November 2007
  16. NAITO T , Kiyasu Y, Sugiyama K, Kimura A, et al
    An influenza virus replicon system in yeast identified Tat-SF1 as a stimulatory host factor for viral RNA synthesis.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


    October 2007
  17. WANG Q , Tian X, Chen X, Ma J, et al
    Structural basis for receptor specificity of influenza B virus hemagglutinin.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


    July 2007
  18. SALOMON R , Hoffmann E, Webster RG
    Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection.
    Proc Natl Acad Sci U S A. 2007;104:12479-81.
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  19. CHUA KB , Crameri G, Hyatt A, Yu M, et al
    A previously unknown reovirus of bat origin is associated with an acute respiratory disease in humans.
    Proc Natl Acad Sci U S A. 2007;104:11424-9.
    PubMed     Related articles    Abstract available   Free Full Text


    June 2007
  20. RANGEL-MORENO J , Moyron-Quiroz JE, Hartson L, Kusser K, et al
    Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


    May 2007
  21. KEDZIERSKA K , Stambas J, Jenkins MR, Keating R, et al
    Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available   Free Full Text


    April 2007
  22. RECKER M , Pybus OG, Nee S, Gupta S, et al
    The generation of influenza outbreaks by a network of host immune responses against a limited set of antigenic types.
    Proc Natl Acad Sci U S A. 2007;.
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  23. MORSE SS
    Pandemic influenza: Studying the lessons of history.
    Proc Natl Acad Sci U S A. 2007;.
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  24. GRIMM D , Staeheli P, Hufbauer M, Koerner I, et al
    Replication fitness determines high virulence of influenza A virus in mice carrying functional Mx1 resistance gene.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  25. HATCHETT RJ , Mecher CE, Lipsitch M
    Public health interventions and epidemic intensity during the 1918 influenza pandemic.
    Proc Natl Acad Sci U S A. 2007;.
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  26. BOOTSMA MC , Ferguson NM
    The effect of public health measures on the 1918 influenza pandemic in U.S. cities.
    Proc Natl Acad Sci U S A. 2007;.
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    March 2007
  27. SHIH AC , Hsiao TC, Ho MS, Li WH, et al
    Simultaneous amino acid substitutions at antigenic sites drive influenza A hemagglutinin evolution.
    Proc Natl Acad Sci U S A. 2007;.
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  28. GALVANI AP , Reluga TC, Chapman GB
    Long-standing influenza vaccination policy is in accord with individual self-interest but not with the utilitarian optimum.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  29. WALLACE RG , Hodac H, Lathrop RH, Fitch WM, et al
    A statistical phylogeography of influenza A H5N1.
    Proc Natl Acad Sci U S A. 2007;104:4473-8.
    PubMed     Related articles    Abstract available


    February 2007
  30. SATTERLY N , Tsai PL, van Deursen J, Nussenzveig DR, et al
    Influenza virus targets the mRNA export machinery and the nuclear pore complex.
    Proc Natl Acad Sci U S A. 2007;104:1853-8.
    PubMed     Related articles    Abstract available


    January 2007
  31. LENSCHOW DJ , Lai C, Frias-Staheli N, Giannakopoulos NV, et al
    IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.
    Proc Natl Acad Sci U S A. 2007;.
    PubMed     Related articles    Abstract available


  32. BUI HH , Peters B, Assarsson E, Mbawuike I, et al
    Ab and T cell epitopes of influenza A virus, knowledge and opportunities.
    Proc Natl Acad Sci U S A. 2007;104:246-51.
    PubMed     Related articles    Abstract available


    December 2006
  33. KILPATRICK AM , Chmura AA, Gibbons DW, Fleischer RC, et al
    From the Cover: Predicting the global spread of H5N1 avian influenza.
    Proc Natl Acad Sci U S A. 2006;103:19368-73.
    PubMed     Related articles    Abstract available


  34. HARRIS A , Cardone G, Winkler DC, Heymann JB, et al
    Influenza virus pleiomorphy characterized by cryoelectron tomography.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


    November 2006
  35. HALDAR J , An D, Alvarez de Cienfuegos L, Chen J, et al
    Polymeric coatings that inactivate both influenza virus and pathogenic bacteria.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


    October 2006
  36. SMITH GJ , Fan XH, Wang J, Li KS, et al
    Emergence and predominance of an H5N1 influenza variant in China.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


  37. KONG WP , Hood C, Yang ZY, Wei CJ, et al
    Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available   Free Full Text


    September 2006
  38. HALE BG , Jackson D, Chen YH, Lamb RA, et al
    Influenza A virus NS1 protein binds p85{beta} and activates phosphatidylinositol-3-kinase signaling.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


    July 2006
  39. MAINES TR , Chen LM, Matsuoka Y, Chen H, et al
    Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


    June 2006
  40. LOWEN AC , Mubareka S, Tumpey TM, Garcia-Sastre A, et al
    The guinea pig as a transmission model for human influenza viruses.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


  41. KEDZIERSKA K , Venturi V, Field K, Davenport MP, et al
    Early establishment of diverse T cell receptor profiles for influenza-specific CD8+CD62Lhi memory T cells.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


    May 2006
  42. VEITS J , Wiesner D, Fuchs W, Hoffmann B, et al
    Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza.
    Proc Natl Acad Sci U S A. 2006;103:8197-202.
    PubMed     Related articles    Abstract available


  43. PARK MS , Steel J, Garcia-Sastre A, Swayne D, et al
    From the Cover: Engineered viral vaccine constructs with dual specificity: Avian influenza and Newcastle disease.
    Proc Natl Acad Sci U S A. 2006;103:8203-8.
    PubMed     Related articles    Abstract available   Free Full Text


    April 2006
  44. HU J , Fu R, Nishimura K, Zhang L, et al
    Histidines, heart of the hydrogen ion channel from influenza A virus: Toward an understanding of conductance and proton selectivity.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


  45. MIN JY , Krug RM
    The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2'-5' oligo (A) synthetase/RNase L pathway.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


  46. GERMANN TC , Kadau K, Longini IM Jr, Macken CA, et al
    Mitigation strategies for pandemic influenza in the United States.
    Proc Natl Acad Sci U S A. 2006;.
    PubMed     Related articles    Abstract available


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