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Articles published in Lancet Oncol

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Single Articles


    February 2018
  1. WILDIERS H, Tryfonidis K, Dal Lago L, Vuylsteke P, et al
    Pertuzumab and trastuzumab with or without metronomic chemotherapy for older patients with HER2-positive metastatic breast cancer (EORTC 75111-10114): an open-label, randomised, phase 2 trial from the Elderly Task Force/Breast Cancer Group.
    Lancet Oncol. 2018 Feb 9. pii: S1470-2045(18)30083.
    PubMed     Text format     Abstract available


  2. BIANUCCI R, Perciaccante A, Charlier P, Appenzeller O, et al
    Earliest evidence of malignant breast cancer in Renaissance paintings.
    Lancet Oncol. 2018;19:166-167.
    PubMed     Text format    


    January 2018
  3. FASCHING PA
    Breast cancer in young women: do BRCA1 or BRCA2 mutations matter?
    Lancet Oncol. 2018 Jan 11. pii: S1470-2045(18)30008.
    PubMed     Text format    


  4. COPSON ER, Maishman TC, Tapper WJ, Cutress RI, et al
    Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study.
    Lancet Oncol. 2018 Jan 11. pii: S1470-2045(17)30891.
    PubMed     Text format     Abstract available


  5. GIANNI L, Bisagni G, Colleoni M, Del Mastro L, et al
    Neoadjuvant treatment with trastuzumab and pertuzumab plus palbociclib and fulvestrant in HER2-positive, ER-positive breast cancer (NA-PHER2): an exploratory, open-label, phase 2 study.
    Lancet Oncol. 2018 Jan 8. pii: S1470-2045(18)30001.
    PubMed     Text format     Abstract available


  6. PIVOT X, Cox DG
    A new era for treatment development in HER2-positive breast cancer.
    Lancet Oncol. 2018 Jan 8. pii: S1470-2045(18)30002.
    PubMed     Text format    


  7. MALAGA G, Cuba-Fuentes S, Romero-Albino Z
    Implementation of a community-based breast cancer management programme.
    Lancet Oncol. 2018;19:e3.
    PubMed     Text format    


    December 2017
  8. BURKI TK
    Improved progression-free survival in metastatic breast cancer.
    Lancet Oncol. 2017 Dec 21. pii: S1470-2045(17)30952.
    PubMed     Text format    


  9. NELSON R
    San Antonio Breast Cancer Symposium 2017.
    Lancet Oncol. 2017 Dec 14. pii: S1470-2045(17)30930.
    PubMed     Text format    


  10. DERKS MGM, van de Velde CJH
    Neoadjuvant chemotherapy in breast cancer: more than just downsizing.
    Lancet Oncol. 2017 Dec 11. pii: S1470-2045(17)30914.
    PubMed     Text format    



  11. Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials.
    Lancet Oncol. 2017 Dec 11. pii: S1470-2045(17)30777.
    PubMed     Text format     Abstract available


  12. SALGADO R, Loi S
    Tumour infiltrating lymphocytes in breast cancer: increasing clinical relevance.
    Lancet Oncol. 2017 Dec 7. pii: S1470-2045(17)30905.
    PubMed     Text format    


  13. DENKERT C, von Minckwitz G, Darb-Esfahani S, Lederer B, et al
    Tumour-infiltrating lymphocytes and prognosis in different subtypes of breast cancer: a pooled analysis of 3771 patients treated with neoadjuvant therapy.
    Lancet Oncol. 2017 Dec 7. pii: S1470-2045(17)30904.
    PubMed     Text format     Abstract available


  14. DI LEO A, Johnston S, Lee KS, Ciruelos E, et al
    Buparlisib plus fulvestrant in postmenopausal women with hormone-receptor-positive, HER2-negative, advanced breast cancer progressing on or after mTOR inhibition (BELLE-3): a randomised, double-blind, placebo-controlled, phase 3 trial.
    Lancet Oncol. 2017 Dec 6. pii: S1470-2045(17)30688.
    PubMed     Text format     Abstract available


  15. HO AY, Hu ZI, Mehrara BJ, Wilkins EG, et al
    Radiotherapy in the setting of breast reconstruction: types, techniques, and timing.
    Lancet Oncol. 2017;18:e742-e753.
    PubMed     Text format     Abstract available


    November 2017
  16. HURVITZ SA, Martin M, Symmans WF, Jung KH, et al
    Neoadjuvant trastuzumab, pertuzumab, and chemotherapy versus trastuzumab emtansine plus pertuzumab in patients with HER2-positive breast cancer (KRISTINE): a randomised, open-label, multicentre, phase 3 trial.
    Lancet Oncol. 2017 Nov 23. pii: S1470-2045(17)30716.
    PubMed     Text format     Abstract available


  17. COLLEONI M, Luo W, Karlsson P, Chirgwin J, et al
    Extended adjuvant intermittent letrozole versus continuous letrozole in postmenopausal women with breast cancer (SOLE): a multicentre, open-label, randomised, phase 3 trial.
    Lancet Oncol. 2017 Nov 17. pii: S1470-2045(17)30715.
    PubMed     Text format     Abstract available


  18. MARTIN M, Holmes FA, Ejlertsen B, Delaloge S, et al
    Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.
    Lancet Oncol. 2017 Nov 13. pii: S1470-2045(17)30717.
    PubMed     Text format     Abstract available


  19. CHAVEZ-MACGREGOR M, Mittendorf EA
    Extended adjuvant therapy in patients with HER2-positive breast cancer: some answers, even more questions.
    Lancet Oncol. 2017 Nov 13. pii: S1470-2045(17)30844.
    PubMed     Text format    


  20. GOURD E
    Thermography should not be used in breast cancer screening.
    Lancet Oncol. 2017 Nov 2. pii: S1470-2045(17)30833.
    PubMed     Text format    


    October 2017
  21. COSTA L, Ferreira AR
    Adjuvant zoledronic acid to treat breast cancer: not for all.
    Lancet Oncol. 2017 Oct 13. pii: S1470-2045(17)30695.
    PubMed     Text format    


  22. COLEMAN R, Hall A, Albanell J, Hanby A, et al
    Effect of MAF amplification on treatment outcomes with adjuvant zoledronic acid in early breast cancer: a secondary analysis of the international, open-label, randomised, controlled, phase 3 AZURE (BIG 01/04) trial.
    Lancet Oncol. 2017 Oct 13. pii: S1470-2045(17)30603.
    PubMed     Text format     Abstract available


  23. GOURD E
    Insulin analog linked to breast cancer risk.
    Lancet Oncol. 2017 Oct 5. pii: S1470-2045(17)30772.
    PubMed     Text format    


  24. DUGGAN C, Dvaladze AL, Tsu V, Jeronimo J, et al
    Resource-stratified implementation of a community-based breast cancer management programme in Peru.
    Lancet Oncol. 2017;18:e607-e617.
    PubMed     Text format     Abstract available


  25. PINEROS M, Ramos W, Antoni S, Abriata G, et al
    Cancer patterns, trends, and transitions in Peru: a regional perspective.
    Lancet Oncol. 2017;18:e573-e586.
    PubMed     Text format     Abstract available


    September 2017
  26. GOURD E
    Pyrotinib shows activity in metastatic breast cancer.
    Lancet Oncol. 2017 Sep 21. pii: S1470-2045(17)30755.
    PubMed     Text format    


  27. EICHBAUM MHR, Kissel N, Neunhoeffer T, Dollas L, et al
    Hypoglossal paresis caused by a solitary breast cancer metasasis at the basal skull.
    Lancet Oncol. 2017;18:e552.
    PubMed     Text format    


    August 2017
  28. DELALOGE S, DeForceville L
    Targeting PI3K/AKT pathway in triple-negative breast cancer.
    Lancet Oncol. 2017 Aug 8. pii: S1470-2045(17)30514.
    PubMed     Text format    


  29. KIM SB, Dent R, Im SA, Espie M, et al
    Ipatasertib plus paclitaxel versus placebo plus paclitaxel as first-line therapy for metastatic triple-negative breast cancer (LOTUS): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
    Lancet Oncol. 2017 Aug 8. pii: S1470-2045(17)30450.
    PubMed     Text format     Abstract available


  30. KERR J, Anderson C, Lippman SM
    Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence.
    Lancet Oncol. 2017;18:e457-e471.
    PubMed     Text format     Abstract available


  31. LEVIS BE, Binkley PF, Shapiro CL
    Cardiotoxic effects of anthracycline-based therapy: what is the evidence and what are the potential harms?
    Lancet Oncol. 2017;18:e445-e456.
    PubMed     Text format     Abstract available


    July 2017
  32. DERKS MGM, Blok EJ, Seynaeve C, Nortier JWR, et al
    Adjuvant tamoxifen and exemestane in women with postmenopausal early breast cancer (TEAM): 10-year follow-up of a multicentre, open-label, randomised, phase 3 trial.
    Lancet Oncol. 2017 Jul 18. pii: S1470-2045(17)30419.
    PubMed     Text format     Abstract available


  33. MATHEW A, Brufsky A
    TACT2: improving treatment tolerability in early breast cancer.
    Lancet Oncol. 2017;18:843-845.
    PubMed     Text format    


    June 2017
  34. DAS M
    Adjuvant pertuzumab improves early breast cancer outcomes.
    Lancet Oncol. 2017 Jun 15. pii: S1470-2045(17)30481.
    PubMed     Text format    


  35. DAS M
    Olaparib provides benefit in metastatic breast cancer.
    Lancet Oncol. 2017 Jun 8. pii: S1470-2045(17)30453.
    PubMed     Text format    


  36. BURKI TK
    Adjuvant capecitabine for HER2-negative breast cancer.
    Lancet Oncol. 2017 Jun 8. pii: S1470-2045(17)30451.
    PubMed     Text format    


  37. CAMERON D, Morden JP, Canney P, Velikova G, et al
    Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer in the randomised UK TACT2 trial (CRUK/05/19): a multicentre, phase 3, open-label, randomised, co
    Lancet Oncol. 2017 Jun 6. pii: S1470-2045(17)30404.
    PubMed     Text format     Abstract available


  38. STEBBING J, Baranau Y, Baryash V, Manikhas A, et al
    CT-P6 compared with reference trastuzumab for HER2-positive breast cancer: a randomised, double-blind, active-controlled, phase 3 equivalence trial.
    Lancet Oncol. 2017 Jun 2. pii: S1470-2045(17)30434.
    PubMed     Text format     Abstract available


    May 2017
  39. CHOPRA N, Turner NC
    Targeting PIK3CA-mutant advanced breast cancer in the clinical setting.
    Lancet Oncol. 2017 May 30. pii: S1470-2045(17)30430.
    PubMed     Text format    


  40. BASELGA J, Im SA, Iwata H, Cortes J, et al
    Buparlisib plus fulvestrant versus placebo plus fulvestrant in postmenopausal, hormone receptor-positive, HER2-negative, advanced breast cancer (BELLE-2): a randomised, double-blind, placebo-controlled, phase 3 trial.
    Lancet Oncol. 2017 May 30. pii: S1470-2045(17)30376.
    PubMed     Text format     Abstract available


  41. KROP IE, Kim SB, Martin AG, LoRusso PM, et al
    Trastuzumab emtansine versus treatment of physician's choice in patients with previously treated HER2-positive metastatic breast cancer (TH3RESA): final overall survival results from a randomised open-label phase 3 trial.
    Lancet Oncol. 2017 May 16. pii: S1470-2045(17)30313.
    PubMed     Text format     Abstract available


  42. MONTEMURRO F
    Trastuzumab emtansine in HER2-positive metastatic breast cancer.
    Lancet Oncol. 2017 May 16. pii: S1470-2045(17)30303.
    PubMed     Text format    


  43. DIERAS V, Miles D, Verma S, Pegram M, et al
    Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial.
    Lancet Oncol. 2017 May 16. pii: S1470-2045(17)30312.
    PubMed     Text format     Abstract available


  44. ALLGOOD PC, Maroni R, Hudson S, Offman J, et al
    Effect of second timed appointments for non-attenders of breast cancer screening in England: a randomised controlled trial.
    Lancet Oncol. 2017 May 15. pii: S1470-2045(17)30340.
    PubMed     Text format     Abstract available


  45. GOURD E
    Switch to exemestane effective in early breast cancer.
    Lancet Oncol. 2017 May 11. pii: S1470-2045(17)30341.
    PubMed     Text format    


  46. EARL HM, Hiller L, Howard HC, Dunn JA, et al
    Addition of gemcitabine to paclitaxel, epirubicin, and cyclophosphamide adjuvant chemotherapy for women with early-stage breast cancer (tAnGo): final 10-year follow-up of an open-label, randomised, phase 3 trial.
    Lancet Oncol. 2017 May 4. pii: S1470-2045(17)30319.
    PubMed     Text format     Abstract available


    April 2017
  47. FOUAD TM, Barrera AM, Reuben JM, Lucci A, et al
    Inflammatory breast cancer: a proposed conceptual shift in the UICC-AJCC TNM staging system.
    Lancet Oncol. 2017;18:e228-e232.
    PubMed     Text format     Abstract available


    March 2017
  48. BURKI TK
    Sacituzumab govitecan activity in advanced breast cancer.
    Lancet Oncol. 2017 Mar 23. pii: S1470-2045(17)30232.
    PubMed     Text format    


  49. RUGO HS, Seneviratne L, Beck JT, Glaspy JA, et al
    Prevention of everolimus-related stomatitis in women with hormone receptor-positive, HER2-negative metastatic breast cancer using dexamethasone mouthwash (SWISH): a single-arm, phase 2 trial.
    Lancet Oncol. 2017 Mar 14. pii: S1470-2045(17)30109.
    PubMed     Text format     Abstract available


    February 2017
  50. MAYOR S
    Service review: improving breast cancer care in Tanzania.
    Lancet Oncol. 2017 Feb 23. pii: S1470-2045(17)30160.
    PubMed     Text format    


  51. MATHEW A, Brufsky A
    Less is more? De-intensification of therapy for early-stage HER2-positive breast cancer.
    Lancet Oncol. 2017 Feb 23. pii: S1470-2045(17)30150.
    PubMed     Text format    


  52. BROWER V
    Scalp cooling and hair loss during breast cancer chemotherapy.
    Lancet Oncol. 2017 Feb 23. pii: S1470-2045(17)30158.
    PubMed     Text format    


  53. LLOMBART-CUSSAC A, Cortes J, Pare L, Galvan P, et al
    HER2-enriched subtype as a predictor of pathological complete response following trastuzumab and lapatinib without chemotherapy in early-stage HER2-positive breast cancer (PAMELA): an open-label, single-group, multicentre, phase 2 trial.
    Lancet Oncol. 2017 Feb 23. pii: S1470-2045(17)30021.
    PubMed     Text format     Abstract available


  54. ZHANG P, Sun T, Zhang Q, Yuan Z, et al
    Utidelone plus capecitabine versus capecitabine alone for heavily pretreated metastatic breast cancer refractory to anthracyclines and taxanes: a multicentre, open-label, superiority, phase 3, randomised controlled trial.
    Lancet Oncol. 2017 Feb 10. pii: S1470-2045(17)30088.
    PubMed     Text format     Abstract available


  55. BROWER V
    Letrozole not superior to anastrozole for early breast cancer.
    Lancet Oncol. 2017 Feb 2. pii: S1470-2045(17)30081.
    PubMed     Text format    


  56. POLGAR C, Ott OJ, Hildebrandt G, Kauer-Dorner D, et al
    Late side-effects and cosmetic results of accelerated partial breast irradiation with interstitial brachytherapy versus whole-breast irradiation after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: 5-year r
    Lancet Oncol. 2017;18:259-268.
    PubMed     Text format     Abstract available


  57. DIKMANS RE, Negenborn VL, Bouman MB, Winters HA, et al
    Two-stage implant-based breast reconstruction compared with immediate one-stage implant-based breast reconstruction augmented with an acellular dermal matrix: an open-label, phase 4, multicentre, randomised, controlled trial.
    Lancet Oncol. 2017;18:251-258.
    PubMed     Text format     Abstract available


    January 2017
  58. LUEN SJ, Salgado R, Fox S, Savas P, et al
    Tumour-infiltrating lymphocytes in advanced HER2-positive breast cancer treated with pertuzumab or placebo in addition to trastuzumab and docetaxel: a retrospective analysis of the CLEOPATRA study.
    Lancet Oncol. 2017;18:52-62.
    PubMed     Text format     Abstract available


    December 2016
  59. TANDAY S
    Duloxetine lessens joint pain in early-stage breast cancer.
    Lancet Oncol. 2016 Dec 15. pii: S1470-2045(16)30656.
    PubMed     Text format    


  60. GOURD K
    San Antonio Breast Cancer Symposium 2016.
    Lancet Oncol. 2016 Dec 15. pii: S1470-2045(16)30658.
    PubMed     Text format    


  61. BURKI TK
    Incidence of breast cancer in women with type 2 diabetes.
    Lancet Oncol. 2016;17:e523.
    PubMed     Text format    


    November 2016
  62. BURKI TK
    Palbociclib improves survival in advanced breast cancer.
    Lancet Oncol. 2016 Nov 24. pii: S1470-2045(16)30619.
    PubMed     Text format    


  63. VENKATESAN P
    Trastuzumab emtansine for HER2-positive breast cancer.
    Lancet Oncol. 2016 Nov 17. pii: S1470-2045(16)30589.
    PubMed     Text format    


    October 2016
  64. BURKI TK
    Ribociclib in HR-positive, HER2-negative breast cancer.
    Lancet Oncol. 2016 Oct 13. pii: S1470-2045(16)30502.
    PubMed     Text format    


  65. JATOI I, Benson JR, Toi M
    De-escalation of axillary surgery in early breast cancer.
    Lancet Oncol. 2016;17:e430-e441.
    PubMed     Text format     Abstract available


    September 2016
  66. ASDOURIAN MS, Skolny MN, Brunelle C, Seward CE, et al
    Precautions for breast cancer-related lymphoedema: risk from air travel, ipsilateral arm blood pressure measurements, skin puncture, extreme temperatures, and cellulitis.
    Lancet Oncol. 2016;17:e392-405.
    PubMed     Text format     Abstract available


    August 2016
  67. BALAKRISHNAN VS
    Physical exercise might affect breast cancer outcomes.
    Lancet Oncol. 2016 Aug 11. pii: S1470-2045(16)30389.
    PubMed     Text format    


  68. BRUFSKY A
    Is there room for bevacizumab in metastatic breast cancer?
    Lancet Oncol. 2016 Aug 5. pii: S1470-2045(16)30295.
    PubMed     Text format    


  69. ZIELINSKI C, Lang I, Inbar M, Kahan Z, et al
    Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer (TURANDOT): primary endpoint results of a randomised, open-label, non-inferiority, phase 3 trial.
    Lancet Oncol. 2016 Aug 5. pii: S1470-2045(16)30154.
    PubMed     Text format     Abstract available


    July 2016
  70. TANDAY S
    IVF treatment not linked to breast cancer.
    Lancet Oncol. 2016 Jul 21. pii: S1470-2045(16)30371.
    PubMed     Text format    


  71. BAKER H
    Adaptive treatments show promise in breast cancer.
    Lancet Oncol. 2016 Jul 14. pii: S1470-2045(16)30315.
    PubMed     Text format    


  72. GHISLAIN I, Zikos E, Coens C, Quinten C, et al
    Health-related quality of life in locally advanced and metastatic breast cancer: methodological and clinical issues in randomised controlled trials.
    Lancet Oncol. 2016;17:e294-304.
    PubMed     Text format     Abstract available


    June 2016
  73. BERNARDI D, Macaskill P, Pellegrini M, Valentini M, et al
    Breast cancer screening with tomosynthesis (3D mammography) with acquired or synthetic 2D mammography compared with 2D mammography alone (STORM-2): a population-based prospective study.
    Lancet Oncol. 2016 Jun 23. pii: S1470-2045(16)30101.
    PubMed     Text format     Abstract available


  74. VAN MAAREN MC, de Munck L, de Bock GH, Jobsen JJ, et al
    10 year survival after breast-conserving surgery plus radiotherapy compared with mastectomy in early breast cancer in the Netherlands: a population-based study.
    Lancet Oncol. 2016 Jun 22. pii: S1470-2045(16)30067.
    PubMed     Text format     Abstract available


  75. BERTUCCI F, Viens P, Birnbaum D
    SPAG5: the ultimate marker of proliferation in early breast cancer?
    Lancet Oncol. 2016 Jun 13. pii: S1470-2045(16)30092.
    PubMed     Text format    


  76. ABDEL-FATAH TM, Agarwal D, Liu DX, Russell R, et al
    SPAG5 as a prognostic biomarker and chemotherapy sensitivity predictor in breast cancer: a retrospective, integrated genomic, transcriptomic, and protein analysis.
    Lancet Oncol. 2016 Jun 13. pii: S1470-2045(16)00174.
    PubMed     Text format     Abstract available


    May 2016
  77. GIANNI L, Pienkowski T, Im YH, Tseng LM, et al
    5-year analysis of neoadjuvant pertuzumab and trastuzumab in patients with locally advanced, inflammatory, or early-stage HER2-positive breast cancer (NeoSphere): a multicentre, open-label, phase 2 randomised trial.
    Lancet Oncol. 2016 May 11. pii: S1470-2045(16)00163.
    PubMed     Text format     Abstract available


  78. BACHELOT T, Campone M, Tredan O
    PI3K targeting in breast cancer: the end of the beginning?
    Lancet Oncol. 2016 May 4. pii: S1470-2045(16)00148.
    PubMed     Text format    


  79. KROP IE, Mayer IA, Ganju V, Dickler M, et al
    Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial.
    Lancet Oncol. 2016 May 4. pii: S1470-2045(16)00106.
    PubMed     Text format     Abstract available


  80. CHAN A, Buyse M, Yao B
    Neratinib after trastuzumab in patients with HER2-positive breast cancer - Author's reply.
    Lancet Oncol. 2016;17:e176-7.
    PubMed     Text format    


  81. HASEGAWA T, Uno H, Wei LJ
    Neratinib after trastuzumab in patients with HER2-positive breast cancer.
    Lancet Oncol. 2016;17:e176.
    PubMed     Text format    


    February 2016
  82. BURKI TK
    Happygram.
    Lancet Oncol. 2016;17:152.
    PubMed     Text format    


  83. BAKER H
    Familial risk in patients with carcinoma of unknown primary.
    Lancet Oncol. 2016;17:e48.
    PubMed     Text format    


    January 2016
  84. EVANS A
    Detection of DCIS and reduced invasive interval cancers.
    Lancet Oncol. 2016;17:14-5.
    PubMed     Text format    


  85. BALAKRISHNAN VS
    Patient risk factors versus physician guidelines for anti-emetics.
    Lancet Oncol. 2016;17:e7.
    PubMed     Text format    


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