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The Medical Article of the Year 2008:
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-78.
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Articles published in BMC Cancer

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    June 2008
  1. SHAO C , Folkard M, Held KD, Prise KM, et al
    Estrogen enhanced cell-cell signalling in breast cancer cells exposed to targeted irradiation.
    BMC Cancer. 2008;8:184.
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  2. XIAO-DONG F , Giretti MS, Goglia L, Flamini MI, et al
    Comparative actions of progesterone, medroxyprogesterone acetate, drospirenone and nestorone on breast cancer cell migration and invasion.
    BMC Cancer. 2008;8:166.
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  3. UEDA S , Tsuda H, Asakawa H, Omata J, et al
    Utility of 18F-fluoro-deoxyglucose emission tomography / computed tomography fusion imaging (18F-FDG PET/CT) in combination with ultrasonography for axillary staging in primary breast cancer.
    BMC Cancer. 2008;8:165.
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  4. LEE K , Liu Y, Mo JQ, Zhang J, et al
    Vav3 oncogene activates estrogen receptor and its overexpression may be involved in human breast cancer.
    BMC Cancer. 2008;8:158.
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  5. ROLLISON DE , Brownson RC, Hathcock HL, Newschaffer CJ, et al
    Case-control study of tobacco smoke exposure and breast cancer risk in Delaware.
    BMC Cancer. 2008;8:157.
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    May 2008
  6. NOETZEL E , Veeck J, Niederacher D, Galm O, et al
    Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer.
    BMC Cancer. 2008;8:154.
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  7. CALLAGY GM , Webber MJ, Pharoah PD, Caldas C, et al
    Meta-analysis confirms BCL2 is an independent prognostic marker in breast Cancer.
    BMC Cancer. 2008;8:153.
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  8. KALLIOMAKI TM , McCallum G, Lunt SJ, Wells PG, et al
    Analysis of the effects of exposure to acute hypoxia on oxidative lesions and tumour progression in a transgenic mouse breast cancer model.
    BMC Cancer. 2008;8:151.
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  9. GONZALEZ LO , Corte MD, Vazquez J, Junquera S, et al
    Androgen receptor expresion in breast cancer: relationship with clinico-pathological characteristics of tumors, prognosis and metalloproteases with their inhibitors expression.
    BMC Cancer. 2008;8:149.
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  10. ZAFRAKAS M , Losen I, Knuechel R, Dahl E, et al
    Enhancer of the rudimentary gene homologue (ERH) expression pattern in sporadic human breast cancer and normal breast tissue.
    BMC Cancer. 2008;8:145.
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  11. LI HZ , Yi TB, Wu ZY
    Suspension culture combined with chemotherapeutic agents for sorting of breast cancer stem cells.
    BMC Cancer. 2008;8:135.
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  12. MALMGREN JA , Atwood MK, Kaplan HG
    Increase in mammography detected breast cancer over time at a community based regional cancer center: a longitudinal cohort study 1990-2005.
    BMC Cancer. 2008;8:131.
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  13. WOOLCOTT CG , Sengupta SK, Hanna WM, Aronson KJ, et al
    Estrogen and progesterone receptor levels in nonneoplastic breast epithelium of breast cancer cases versus benign breast biopsy controls.
    BMC Cancer. 2008;8:130.
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  14. GUILBERT A , Dhennin-Duthille I, El Hiani Y, Haren N, et al
    Expression of TRPC6 channels in human epithelial breast cancer cells.
    BMC Cancer. 2008;8:125.
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  15. SIDDIQA A , Long LM, Li L, Marciniak RA, et al
    Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways.
    BMC Cancer. 2008;8:129.
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  16. LIJOVIC M , Davis SR, Fradkin P, La China M, et al
    Use of a cancer registry is preferable to a direct-to-community approach for recruitment to a cohort study of wellbeing in women newly diagnosed with invasive breast cancer.
    BMC Cancer. 2008;8:126.
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    April 2008
  17. KIM JB , Ko E, Han W, Lee JE, et al
    CD24 cross-linking induces apoptosis in, and inhibits migration of, MCF-7 breast cancer cells.
    BMC Cancer. 2008;8:118.
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  18. GONZALEZ-HORMAZABAL P , Bravo T, Blanco R, Valenzuela CY, et al
    Association of common ATM variants with familial breast cancer in a South American population.
    BMC Cancer. 2008;8:117.
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  19. PIROTH MD , Pinkawa M, Gagel B, Stanzel S, et al
    Sequencing chemotherapy and radiotherapy in locoregional advanced breast cancer patients after mastectomy: a retrospective analysis.
    BMC Cancer. 2008;8:114.
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  20. CLETON-JANSEN AM , Van Eijk R, Lombaerts M, Schmidt MK, et al
    ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: Absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism.
    BMC Cancer. 2008;8:105.
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  21. BATISTA LI , Lu KH, Beahm EK, Arun BK, et al
    Coordinated prophylactic surgical management for women with hereditary breast-ovarian cancer syndrome.
    BMC Cancer. 2008;8:101.
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  22. JEANNERET-SOZZI W , Taghian A, Epelbaum R, Poortmans P, et al
    Primary breast lymphoma: patient profile, outcome and prognostic factors. A multicentre Rare Cancer Network study.
    BMC Cancer. 2008;8:86.
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    March 2008
  23. ZHANG B , Cao X, Liu Y, Cao W, et al
    Tumor-derived Matrix Metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer.
    BMC Cancer. 2008;8:83.
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  24. DECOCK J , Hendrickx W, Vanleeuw U, Van Belle V, et al
    Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis.
    BMC Cancer. 2008;8:77.
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  25. PELEKANOU V , Kampa M, Kafousi M, Darivianaki K, et al
    Expression of TNF-superfamily members BAFF and APRIL in breast cancer: Immunohistochemical study in 52 invasive ductal breast carcinomas.
    BMC Cancer. 2008;8:76.
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  26. BALTZELL KA , Moghadassi M, Rice T, Sison J, et al
    Epithelial cells in nipple aspirate fluid and subsequent breast cancer risk: a historic prospective study.
    BMC Cancer. 2008;8:75.
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  27. GARVIN S , Dabrosin C
    In vivo measurement of tumor estradiol and Vascular Endothelial Growth Factor in breast cancer patients.
    BMC Cancer. 2008;8:73.
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  28. KILPIVAARA O , Rantanen M, Tamminen A, Aittomaki K, et al
    Comprehensive analysis of NuMA variation in breast cancer.
    BMC Cancer. 2008;8:71.
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  29. LARSON PS , Schlechter BL, King CL, Yang Q, et al
    CDKN1C/p57kip2 is a candidate tumor suppressor gene in human breast cancer.
    BMC Cancer. 2008;8:68.
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  30. KOHRT HE , Olshen RA, Bermas HR, Goodson WH, et al
    New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients.
    BMC Cancer. 2008;8:66.
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    February 2008
  31. KRAINICK-STROBEL UE , Lichtenegger W, Wallwiener D, Tulusan AH, et al
    Neoadjuvant letrozole in postmenopausal estrogen and/or progesterone receptor positive breast cancer: a phase IIb/III trial to investigate optimal duration of preoperative endocrine therapy.
    BMC Cancer. 2008;8:62.
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  32. GHEBEH H , Barhoush E, Tulbah A, Elkum N, et al
    FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy.
    BMC Cancer. 2008;8:57.
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  33. BERLIERE M , Dalenc F, Malingret N, Vindevoghel A, et al
    Incidence of reversible amenorrhea in women with breast cancer undergoing adjuvant anthracycline-based chemotherapy with or without docetaxel.
    BMC Cancer. 2008;8:56.
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  34. MIKHITARIAN K , Hebert Martin R, Baker Ruppel M, Gillanders WE, et al
    Detection of mammaglobin mRNA in peripheral blood is associated with high grade breast cancer: interim results of a prospective cohort study.
    BMC Cancer. 2008;8:55.
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  35. REINCKE S , Govbakh L, Wilhelm B, Jin H, et al
    Mutation analysis of the MDM4 gene in German breast cancer patients.
    BMC Cancer. 2008;8:52.
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  36. BEKTAS N , Ten Haaf A, Veeck J, Wild PJ, et al
    Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer.
    BMC Cancer. 2008;8:42.
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  37. LEREBOURS F , Vacher S, Andrieu C, Espie M, et al
    NF-kappa B genes have a major role in Inflammatory Breast Cancer.
    BMC Cancer. 2008;8:41.
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    January 2008
  38. PLUMER A , Duan H, Subramaniam S, Lucas FL, et al
    Development of fragment-specific osteopontin antibodies and ELISA for quantification in human metastatic breast cancer.
    BMC Cancer. 2008;8:38.
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  39. COSTA S , Pinto D, Pereira D, Rodrigues H, et al
    Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer.
    BMC Cancer. 2008;8:32.
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  40. BEN HAMIDA A , Labidi IS, Mrad K, Charafe-Jauffret E, et al
    Markers of subtypes in inflammatory breast cancer studied by immunohistochemistry: prominent expression of P-cadherin.
    BMC Cancer. 2008;8:28.
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  41. GLYNN SA , O'Sullivan D, Eustace AJ, Clynes M, et al
    The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells.
    BMC Cancer. 2008;8:9.
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  42. ONAY UV , Aaltonen K, Briollais L, Knight JA, et al
    Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk.
    BMC Cancer. 2008;8:6.
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  43. ZHANG XH , Huang DP, Guo GL, Chen GR, et al
    Coexpression of VEGF-C and COX-2 and its association with lymphangiogenesis in human breast cancer.
    BMC Cancer. 2008;8:4.
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  44. KULKARNI S , Patil DB, Diaz LK, Wiley EL, et al
    COX-2 and PPARgamma expression are potential markers of recurrence risk in mammary duct carcinoma in-situ.
    BMC Cancer. 2008;8:36.
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  45. LYNG MB , Laenkholm AV, Pallisgaard N, Ditzel HJ, et al
    Identification of genes for normalization of real-time RT-PCR data in breast carcinomas.
    BMC Cancer. 2008;8:20.
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  46. TAKANO EA , Mitchell G, Fox SB, Dobrovic A, et al
    Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis.
    BMC Cancer. 2008;8:59.
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  47. SAUTER ER , Qin W, Hewett JE, Ruhlen RL, et al
    Celecoxib concentration predicts decrease in prostaglandin E2 concentrations in nipple aspirate fluid from high risk women.
    BMC Cancer. 2008;8:49.
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  48. SIMOENS C , Lardon F, Pauwels B, De Pooter CM, et al
    Comparative study of the radiosensitizing and cell cycle effects of vinflunine and vinorelbine, in vitro.
    BMC Cancer. 2008;8:65.
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  49. MARINHO VF , Metze K, Sanches FS, Rocha GF, et al
    Lymph vascular invasion in invasive mammary carcinomas identified by the endothelial lymphatic marker D2-40 is associated with other indicators of poor prognosis.
    BMC Cancer. 2008;8:64.
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  50. HAMM A , Veeck J, Bektas N, Wild PJ, et al
    Frequent expression loss of Inter-alpha-trypsin inhibitor heavy chain (ITIH) genes in multiple human solid tumors: a systematic expression analysis.
    BMC Cancer. 2008;8:25.
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  51. KOROURIAN S , Siegel E, Kieber-Emmons T, Monzavi-Karbassi B, et al
    Expression analysis of carbohydrate antigens in ductal carcinoma in situ of the breast by lectin histochemistry.
    BMC Cancer. 2008;8:136.
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  52. HUBBARD K , Catalano J, Puri RK, Gnatt A, et al
    Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.
    BMC Cancer. 2008;8:133.
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  53. KHEDHAIER A , Hassen E, Bouaouina N, Gabbouj S, et al
    Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma.
    BMC Cancer. 2008;8:109.
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  54. VYDRA J , Selicharova I, Smutna K, Sanda M, et al
    Two-dimensional electrophoretic comparison of metastatic and non-metastatic human breast tumors using in vitro cultured epithelial cells derived from the cancer tissues.
    BMC Cancer. 2008;8:107.
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  55. PAVLAKIS K , Messini I, Vrekoussis T, Yiannou P, et al
    The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions.
    BMC Cancer. 2008;8:88.
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  56. JANG JY , Choi Y, Jeon YK, Aung KC, et al
    Over-expression of adenine nucleotide translocase 1 (ANT1) induces apoptosis and tumor regression in vivo.
    BMC Cancer. 2008;8:160.
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    December 2007
  57. ELKUM N , Dermime S, Ajarim D, Al-Zahrani A, et al
    Being 40 or younger is an independent risk factor for relapse in operable breast cancer patients: The Saudi Arabia experience.
    BMC Cancer. 2007;7:222.
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    November 2007
  58. YANG S , Du J, Wang Z, Yuan W, et al
    BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells.
    BMC Cancer. 2007;7:211.
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  59. KEAM B , Im SA, Kim HJ, Oh DY, et al
    Prognostic impact of clinicopathologic parameters in stage II/III breast cancer treated with neoadjuvant docetaxel and doxorubicin chemotherapy: paradoxical features of the triple negative breast cancer.
    BMC Cancer. 2007;7:203.
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    September 2007
  60. YU JX , Sieuwerts AM, Zhang Y, Martens JW, et al
    Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer.
    BMC Cancer. 2007;7:182.
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  61. MANDAL S , Davie J
    An integrated analysis of genes and pathways exhibiting metabolic differences between estrogen receptor positive breast cancer cells.
    BMC Cancer. 2007;7:181.
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  62. MAHESHKUMAR MJ , Ponvijay KS, Nandhini R, Nagarajan RS, et al
    A mouse model for Luminal epithelial like ER positive subtype of human breast cancer.
    BMC Cancer. 2007;7:180.
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  63. COX DG , Penney K, Guo Q, Hankinson SE, et al
    TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.
    BMC Cancer. 2007;7:175.
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  64. WANG L , Li D, Fu Z, Li H, et al
    Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population.
    BMC Cancer. 2007;7:173.
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  65. PALLI D , Falchetti M, Masala G, Lupi R, et al
    Association between the BRCA2 N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy.
    BMC Cancer. 2007;7:170.
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    August 2007
  66. BEURSKENS CH , van Uden CJ, Strobbe LJ, Oostendorp RA, et al
    The efficacy of physiotherapy upon shoulder function following axillary dissection in breast cancer, a randomized controlled study.
    BMC Cancer. 2007;7:166.
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  67. MARGOLIN S , Eiberg H, Lindblom A, Bisgaard ML, et al
    CHEK2 1100delC is prevalent in Swedish early onset familial breast cancer.
    BMC Cancer. 2007;7:163.
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  68. ECCLES D , Gerty S, Simmonds P, Hammond V, et al
    Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): Study Protocol.
    BMC Cancer. 2007;7:160.
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  69. GARCIA-TUNON I , Ricote M, Ruiz A, Fraile B, et al
    Influence of IFN-gamma and its receptors in human breast cancer.
    BMC Cancer. 2007;7:158.
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  70. MELICHAR B , Hyspler R, Dragounova E, Dvorak J, et al
    Gastrointestinal permeability in ovarian cancer and breast cancer patients treated with paclitaxel and platinum.
    BMC Cancer. 2007;7:155.
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  71. VIANI GA , Afonso SL, Stefano EJ, De Fendi LI, et al
    Adjuvant trastuzumab in the treatment of HER-2-positive early breast cancer: a meta-analyses of published randomized trials.
    BMC Cancer. 2007;7:153.
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  72. FRIEDENSON B
    The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers.
    BMC Cancer. 2007;7:152.
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  73. ZHANG Y , Pu X, Shi M, Chen L, et al
    Critical role of c-Jun overexpression in liver metastasis of human breast cancer xenograft model.
    BMC Cancer. 2007;7:145.
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    July 2007
  74. SJOBAKK TE , Johansen R, Bathen TF, Sonnewald U, et al
    Metabolic profiling of human brain metastases using in vivo proton MR spectroscopy at 3T.
    BMC Cancer. 2007;7:141.
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  75. HAMMAMIEH R , Sumaida D, Zhang X, Das R, et al
    Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism.
    BMC Cancer. 2007;7:138.
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  76. KNOSTMAN KA , McCubrey JA, Morrison CD, Zhang Z, et al
    PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer.
    BMC Cancer. 2007;7:137.
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  77. HAFFNER MC , Petridou B, Peyrat JP, Revillion F, et al
    Favorable Prognostic Value of SOCS2 and IGF-I in Breast Cancer.
    BMC Cancer. 2007;7:136.
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  78. TISCHKOWITZ M , Brunet JS, Begin LR, Huntsman DG, et al
    Use of immunohistochemical markers can refine prognosis in triple negative breast cancer.
    BMC Cancer. 2007;7:134.
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  79. PALOMBA G , Cossu A, Friedman E, Budroni M, et al
    Origin and distribution of the BRCA2-8765delAG mutation in breast cancer.
    BMC Cancer. 2007;7:132.
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  80. VINAYAGAM R , Sibson DR, Holcombe C, Aachi V, et al
    Association of oestrogen receptor beta 2 (ERbeta2/ERbetacx) with outcome of adjuvant endocrine treatment for primary breast cancer - a retrospective study.
    BMC Cancer. 2007;7:131.
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  81. WONG PS , Matsumura F
    Promotion of breast cancer by beta-Hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice.
    BMC Cancer. 2007;7:130.
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  82. DEFOSSEZ G , Mathoulin-Pelissier S, Ingrand I, Gasquet I, et al
    Satisfaction with care among patients with non-metastatic breast cancer: development and first steps of validation of the REPERES-60 questionnaire.
    BMC Cancer. 2007;7:129.
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  83. DE KOK M , Frotscher CN, van der Weijden T, Kessels AG, et al
    Introduction of a breast cancer care programme including ultra short hospital stay in 4 early adopter centres: framework for an implementation study.
    BMC Cancer. 2007;7:117.
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    June 2007
  84. BOOTH CM , Dranitsaris G, Gainford C, Berry S, et al
    External influences and priority-setting for anti-cancer agents: a case study of media coverage in adjuvant trastuzumab for breast cancer.
    BMC Cancer. 2007;7:110.
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  85. BALASUBRAMANIAN SP , Cross SS, Globe J, Cox A, et al
    Endostatin gene variation and protein levels in breast cancer susceptibility and severity.
    BMC Cancer. 2007;7:107.
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  86. AWADALLA AW , Ohaeri JU, Gholoum A, Khalid AO, et al
    Factors associated with quality of life of outpatients with breast cancer and gynecologic cancers and their family caregivers: a controlled study.
    BMC Cancer. 2007;7:102.
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  87. FIGUEIREDO JC , Knight JA, Cho S, Savas S, et al
    Polymorphisms cMyc-N11S and p27-V109G and breast cancer risk and prognosis.
    BMC Cancer. 2007;7:99.
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  88. TURTURRO F , Friday E, Welbourne T
    Hyperglycemia regulates thioredoxin-ROS activity through induction of thioredoxin-interacting protein (TXNIP) in metastatic breast cancer-derived cells MDA-MB-231.
    BMC Cancer. 2007;7:96.
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    May 2007
  89. NAUGHTON MJ , Ellis M
    "I'm pregnant and I have breast cancer"
    BMC Cancer. 2007;7:93.
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  90. EPSTEIN RJ
    Adjuvant breast cancer chemotherapy during late-trimester pregnancy: not quite a standard of care.
    BMC Cancer. 2007;7:92.
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  91. FRANK B , Hemminki K, Meindl A, Wappenschmidt B, et al
    BRIP1 (BACH1) variants and familial breast cancer risk.
    BMC Cancer. 2007;7:83.
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  92. MENENDEZ JA , Vazquez-Martin A, Colomer R, Brunet J, et al
    Olive oil's bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells.
    BMC Cancer. 2007;7:80.
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  93. POLLAN M , Ramis R, Aragones N, Perez-Gomez B, et al
    Municipal distribution of breast cancer mortality among women in Spain.
    BMC Cancer. 2007;7:78.
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  94. LEE TS , Kilbreath SL, Sullivan G, Refshauge KM, et al
    The development of an arm activity survey for breast cancer survivors using the Protection Motivation Theory.
    BMC Cancer. 2007;7:75.
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  95. FABRE-LAFAY S , Monville F, Garrido-Urbani S, Berruyer-Pouyet C, et al
    Nectin-4 is a new histological and serological tumor associated marker for breast cancer.
    BMC Cancer. 2007;7:73.
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  96. JACK RH , Davies EA, Robinson D, Sainsbury R, et al
    Radiotherapy waiting times for women with breast cancer: a population-based cohort study.
    BMC Cancer. 2007;7:71.
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    April 2007
  97. LEE KH , Im SA, Oh DY, Lee SH, et al
    Prognostic significance of bcl-2 expression in stage III breast cancer patients who had received doxorubicin and cyclophosphamide followed by paclitaxel as an adjuvant chemotherapy.
    BMC Cancer. 2007;7:63.
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  98. KORKOLA JE , Blaveri E, Devries S, Moore DH 2nd, et al
    Identification of a robust gene signature that predicts breast cancer outcome in independent data sets.
    BMC Cancer. 2007;7:61.
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