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  Alzheimer's Disease

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Articles published in Proc Natl Acad Sci U S A

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    November 2017
  1. YANG J, Zhang X, Yuan P, Yang J, et al
    Oxalate-curcumin-based probe for micro- and macroimaging of reactive oxygen species in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Nov 6. pii: 201706248.
    PubMed     Text format     Abstract available


    October 2017
  2. VOLMAR CH, Salah-Uddin H, Janczura KJ, Halley P, et al
    M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.
    Proc Natl Acad Sci U S A. 2017;114:E9135-E9144.
    PubMed     Text format     Abstract available


  3. ANDREW RJ, Fernandez CG, Stanley M, Jiang H, et al
    Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 23. pii: 201708568.
    PubMed     Text format     Abstract available


  4. MANO T, Nagata K, Nonaka T, Tarutani A, et al
    Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 17. pii: 201707151.
    PubMed     Text format     Abstract available


  5. RUBINSZTEIN DC
    RIPK1 promotes inflammation and beta-amyloid accumulation in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Oct 2. pii: 201715241.
    PubMed     Text format    


    September 2017
  6. OFENGEIM D, Mazzitelli S, Ito Y, DeWitt JP, et al
    RIPK1 mediates a disease-associated microglial response in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Sep 13. pii: 201714175.
    PubMed     Text format     Abstract available


  7. PARASKEVAIDI M, Morais CLM, Lima KMG, Snowden JS, et al
    Differential diagnosis of Alzheimer's disease using spectrochemical analysis of blood.
    Proc Natl Acad Sci U S A. 2017 Sep 5. pii: 201701517.
    PubMed     Text format     Abstract available


    July 2017
  8. KESKIN AD, Kekus M, Adelsberger H, Neumann U, et al
    BACE inhibition-dependent repair of Alzheimer's pathophysiology.
    Proc Natl Acad Sci U S A. 2017 Jul 24. pii: 201708106.
    PubMed     Text format     Abstract available


    June 2017
  9. KUNDRA R, Ciryam P, Morimoto RI, Dobson CM, et al
    Protein homeostasis of a metastable subproteome associated with Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Jun 26. pii: 201618417.
    PubMed     Text format     Abstract available


    May 2017
  10. LI Q, Navakkode S, Rothkegel M, Soong TW, et al
    Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 May 8. pii: 201613700.
    PubMed     Text format     Abstract available


    March 2017
  11. WANG BJ, Her GM, Hu MK, Chen YW, et al
    ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Mar 28. pii: 201618804.
    PubMed     Text format     Abstract available


  12. ZHANG Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, et al
    Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
    Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201615036.
    PubMed     Text format     Abstract available


    January 2017
  13. PERANI D, Farsad M, Ballarini T, Lubian F, et al
    The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer's dementia.
    Proc Natl Acad Sci U S A. 2017 Jan 30. pii: 201610909.
    PubMed     Text format     Abstract available


  14. KELLEHER RJ 3RD, Shen J
    Presenilin-1 mutations and Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2017 Jan 12. pii: 201619574.
    PubMed     Text format    


    December 2016
  15. HABCHI J, Chia S, Limbocker R, Mannini B, et al
    Systematic development of small molecules to inhibit specific microscopic steps of Abeta42 aggregation in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2016 Dec 23. pii: 201615613.
    PubMed     Text format     Abstract available


    November 2016
  16. WOERMAN AL, Aoyagi A, Patel S, Kazmi SA, et al
    Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells.
    Proc Natl Acad Sci U S A. 2016 Nov 28. pii: 201616344.
    PubMed     Text format     Abstract available


    October 2016
  17. KATSOURI L, Lim YM, Blondrath K, Eleftheriadou I, et al
    PPARgamma-coactivator-1alpha gene transfer reduces neuronal loss and amyloid-beta generation by reducing beta-secretase in an Alzheimer's disease model.
    Proc Natl Acad Sci U S A. 2016;113:12292-12297.
    PubMed     Text format     Abstract available


  18. ZHANG X, Mormino EC, Sun N, Sperling RA, et al
    Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2016 Oct 4. pii: 201611073.
    PubMed     Text format     Abstract available


    August 2016
  19. EISENBERG DS, Sawaya MR
    Implications for Alzheimer's disease of an atomic resolution structure of amyloid-beta(1-42) fibrils.
    Proc Natl Acad Sci U S A. 2016 Aug 9. pii: 201610806.
    PubMed     Text format    


    April 2016
  20. BETTAYEB K, Hooli BV, Parrado AR, Randolph L, et al
    Relevance of the COPI complex for Alzheimer's disease progression in vivo.
    Proc Natl Acad Sci U S A. 2016 Apr 25. pii: 201604176.
    PubMed     Text format     Abstract available


  21. FU AK, Hung KW, Yuen MY, Zhou X, et al
    IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline.
    Proc Natl Acad Sci U S A. 2016 Apr 18. pii: 201604032.
    PubMed     Text format     Abstract available


  22. CIRYAM P, Kundra R, Freer R, Morimoto RI, et al
    A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation.
    Proc Natl Acad Sci U S A. 2016 Apr 11. pii: 201516604.
    PubMed     Text format     Abstract available


  23. PINOTSI D, Michel CH, Buell AK, Laine RF, et al
    Nanoscopic insights into seeding mechanisms and toxicity of alpha-synuclein species in neurons.
    Proc Natl Acad Sci U S A. 2016;113:3815-9.
    PubMed     Text format     Abstract available


    March 2016
  24. SENEVIRATNE U, Nott A, Bhat VB, Ravindra KC, et al
    S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration.
    Proc Natl Acad Sci U S A. 2016 Mar 24. pii: 201521318.
    PubMed     Text format     Abstract available


  25. SPRINGER SA, Schwarz F, Altheide TK, Varki NM, et al
    Reply to Liu and Jiang: Maintenance of postreproductive cognitive capacity by inclusive fitness.
    Proc Natl Acad Sci U S A. 2016;113:E1591-2.
    PubMed     Text format    


  26. LIU G, Jiang Q
    Alzheimer's disease CD33 rs3865444 variant does not contribute to cognitive performance.
    Proc Natl Acad Sci U S A. 2016 Mar 1. pii: 201600852.
    PubMed     Text format    


    February 2016
  27. MARSH SE, Abud EM, Lakatos A, Karimzadeh A, et al
    The adaptive immune system restrains Alzheimer's disease pathogenesis by modulating microglial function.
    Proc Natl Acad Sci U S A. 2016 Feb 16. pii: 201525466.
    PubMed     Text format     Abstract available


    January 2016
  28. URBAN S
    Nicastrin guards Alzheimer's gate.
    Proc Natl Acad Sci U S A. 2016 Jan 25. pii: 201524151.
    PubMed     Text format    


  29. HAWKES K
    Genomic evidence for the evolution of human postmenopausal longevity.
    Proc Natl Acad Sci U S A. 2016;113:17-8.
    PubMed     Text format    


  30. SCHWARZ F, Springer SA, Altheide TK, Varki NM, et al
    Human-specific derived alleles of CD33 and other genes protect against postreproductive cognitive decline.
    Proc Natl Acad Sci U S A. 2016;113:74-9.
    PubMed     Text format     Abstract available


    September 2015
  31. ZHU L, Zhong M, Elder GA, Sano M, et al
    Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2015 Sep 8. pii: 201510011.
    PubMed     Text format     Abstract available


    July 2015
  32. OHNISHI T, Yanazawa M, Sasahara T, Kitamura Y, et al
    Na, K-ATPase alpha3 is a death target of Alzheimer patient amyloid-beta assembly.
    Proc Natl Acad Sci U S A. 2015 Jul 29. pii: 201421182.
    PubMed     Text format     Abstract available


  33. ZHANG X, Tian Y, Zhang C, Tian X, et al
    Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2015 Jul 21. pii: 201505420.
    PubMed     Text format     Abstract available


  34. CORBETT GT, Gonzalez FJ, Pahan K
    Activation of peroxisome proliferator-activated receptor alpha stimulates ADAM10-mediated proteolysis of APP.
    Proc Natl Acad Sci U S A. 2015;112:8445-50.
    PubMed     Text format     Abstract available


    June 2015
  35. GOWRISHANKAR S, Yuan P, Wu Y, Schrag M, et al
    Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaques.
    Proc Natl Acad Sci U S A. 2015 Jun 29. pii: 201510329.
    PubMed     Text format     Abstract available


    May 2015
  36. SUN L, Zhao L, Yang G, Yan C, et al
    Structural basis of human gamma-secretase assembly.
    Proc Natl Acad Sci U S A. 2015;112:6003-8.
    PubMed     Text format     Abstract available


    April 2015
  37. ABELEIN A, Graslund A, Danielsson J
    Zinc as chaperone-mimicking agent for retardation of amyloid beta peptide fibril formation.
    Proc Natl Acad Sci U S A. 2015;112:5407-12.
    PubMed     Text format     Abstract available


  38. BARRIO JR, Small GW, Wong KP, Huang SC, et al
    In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging.
    Proc Natl Acad Sci U S A. 2015 Apr 6. pii: 201409952.
    PubMed     Text format     Abstract available


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