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Alzheimer's Disease

Free Subscription Articles published in J Biol Chem Retrieve available abstracts of 111 articles: HTML format Text format

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January 2012
1. ZHENG X , Gessel MM, Wisniewski ML, Viswanathan K, et al
   Z-Phe-Ala-diazomethylketone (PADK) disrupts and remodels the early oligomer states of the Alzheimer's disease Abeta42 protein.
   J Biol Chem. 2012.
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2. SADLEIR KR , Vassar R
   CDK5 inhibition and Abeta42 increase BACE1 level in primary neurons by a post-transcriptional mechanism: Implications of CDK5 AS A therapeutic target for Alzheimer's disease.
   J Biol Chem. 2012.
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3. MORI T , Rezai-Zadeh K, Koyama N, Arendash GW, et al
   Tannic Acid is a Natural beta-secretase Inhibitor that Prevents Cognitive Impairment and Mitigates Alzheimer-like Pathology in Transgenic Mice.
   J Biol Chem. 2012.
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   December 2011
4. MA SL , Pastorino L, Zhou XZ, Lu KP, et al
   Propyl isomerase Pin1 promotes APP protein turnover by inhibiting GSK3beta kinase activity: A novel mechanism for Pin1 to protect against Alzheimer's disease.
   J Biol Chem. 2011.
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5. PAUWELS K , Williams TL, Morris KL, Jonckheere W, et al
   The structural basis for increased toxicity of pathological Abeta42:Abeta40 ratios in Alzheimer's disease.
   J Biol Chem. 2011.
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6. LEE M , Kang Y, Suk K, Schwab C, et al
   Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein.
   J Biol Chem. 2011;286:41230-45.
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7. CHAN RB , Oliveira TG, Cortes EP, Honig LS, et al
   Comparative lipidomic analysis of mouse and human brain with Alzheimer's disease.
   J Biol Chem. 2011.
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   November 2011
8. NENISKYTE U , Neher JJ, Brown GC
   Neuronal death induced by nanomolar amyloid beta is mediated by primary phagocytosis of neurons by microglia.
   J Biol Chem. 2011;286:39904-13.
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9. AIRAVAARA M , Pletnikova O, Doyle ME, Zhang YE, et al
   Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease.
   J Biol Chem. 2011.
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10. MURAKAMI K , Murata N, Noda Y, Tahara S, et al
    SOD1 deficiency drives amyloid beta oligomerization and memory loss in a mouse model of Alzheimer's disease.
    J Biol Chem. 2011.
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11. SAMAN S , Kim W, Raya M, Visnick Y, et al
    Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid (CSF) in early Alzheimer's Disease.
    J Biol Chem. 2011.
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12. FASSLER M , Li X, Kaether C
    Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and gamma-secretase complex stabilization.
    J Biol Chem. 2011;286:38390-6.
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13. BATE C , Williams A
    Amyloid-beta-induced synapse damage is mediated via cross-linkage of cellular prion proteins.
    J Biol Chem. 2011;286:37955-63.
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    October 2011
14. 
    Taking a load off the brain.
    J Biol Chem. 2011;286:e99971.
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15. KILGER E , Buehler A, Woelfing H, Kumar S, et al
    BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE).
    J Biol Chem. 2011;286:37446-57.
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16. STIEREN ES , El Ayadi A, Xiao Y, Siller E, et al
    Ubiquilin-1 is a molecular chaperone for the amyloid precursor protein.
    J Biol Chem. 2011;286:35689-98.
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17. COSTA R , Speretta E, Crowther DC, Cardoso I, et al
    Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer's disease.
    J Biol Chem. 2011.
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18. XIONG F , Leonov S, Howard AC, Xiong S, et al
    Receptor for advanced glycation end products (RAGE) prevents endothelial cell membrane resealing and regulates F-actin remodeling in a beta-catenin-dependent manner.
    J Biol Chem. 2011;286:35061-70.
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    September 2011
19. CHAI X , Wu S, Murray TK, Kinley R, et al
    Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.
    J Biol Chem. 2011;286:34457-67.
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20. OLAH J , Vincze O, Virok D, Simon D, et al
    Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
    J Biol Chem. 2011;286:34088-100.
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21. JAWHAR S , Wirths O, Bayer TA
    Pyroglutamate Abeta -- a hatchet man in Alzheimer disease.
    J Biol Chem. 2011.
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22. LAMBERTO GR , Torres-Monserrat V, Bertoncini CW, Salvatella X, et al
    Toward the discovery of effective polycyclic inhibitors of alpha-synuclein amyloid assembly.
    J Biol Chem. 2011;286:32036-44.
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23. PAMREN A , Wanngren J, Tjernberg LO, Winblad B, et al
    Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.
    J Biol Chem. 2011;286:31153-8.
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    August 2011
24. MA B , Nussinov R
    Polymorphic triple beta-sheet structures contribute to amide H/D exchange protection in Alzheimer's amyloid beta42.
    J Biol Chem. 2011.
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    July 2011
25. PEDERSEN JT , Ostergaard J, Rozlosnik N, Gammelgaard B, et al
    Cu(II) mediates kinetically distinct, non-amyloidogenic aggregation of amyloid-beta peptides.
    J Biol Chem. 2011;286:26952-63.
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26. SCHIEB H , Kratzin H, Jahn O, Moebius W, et al
    {beta}-amyloid peptide variants in brains and cerebrospinal fluid from APP transgenic mice: Comparison with human Alzheimer's amyloid.
    J Biol Chem. 2011.
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27. CHO SH , Sun B, Zhou Y, Kauppinen TM, et al
    CX3CR1 modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer's disease.
    J Biol Chem. 2011.
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    June 2011
28. RENZI F , Zhang X, Rice WJ, Torres-Arancivia C, et al
    Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy.
    J Biol Chem. 2011;286:21440-9.
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29. WEGMANN S , Scholer J, Bippes CA, Mandelkow E, et al
    Competing interactions stabilize pro- and anti-aggregant conformations of human Tau.
    J Biol Chem. 2011;286:20512-24.
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30. LU Y , Li T, Qureshi HY, Han D, et al
    Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain.
    J Biol Chem. 2011;286:20569-81.
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    May 2011
31. FREUDE KK , Penjwini M, Davis JL, Laferla FM, et al
    Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells.
    J Biol Chem. 2011.
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32. NISHITSUJI K , Hosono T, Nakamura T, Bu G, et al
    Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain barrier model.
    J Biol Chem. 2011;286:17536-42.
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33. SHI Q , Xu H, Yu H, Zhang N, et al
    Inactivation and reactivation of the mitochondrial alpha-ketoglutarate dehydrogenase complex.
    J Biol Chem. 2011;286:17640-8.
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34. BRODBECK J , McGuire J, Liu Z, Meyer-Franke A, et al
    Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors.
    J Biol Chem. 2011;286:17217-26.
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35. SHEWMAKER F , McGlinchey RP, Wickner RB
    Structural insights into functional and pathological amyloid.
    J Biol Chem. 2011;286:16533-40.
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36. JINWAL UK , Trotter JH, Abisambra JF, Koren J 3rd, et al
    The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics.
    J Biol Chem. 2011;286:16976-83.
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37. PATTERSON KR , Remmers C, Fu Y, Brooker S, et al
    Characterization of prefibrillar tau oligomers in vitro and in Alzheimers disease.
    J Biol Chem. 2011.
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    April 2011
38. NAG S , Sarkar B, Bandyopadhyay A, Sahoo B, et al
    Nature of the amyloid-beta monomer and the monomer-oligomer equilibrium.
    J Biol Chem. 2011;286:13827-33.
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39. HICKMAN DT , Lopez-Deber MP, Ndao DM, Silva AB, et al
    Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.
    J Biol Chem. 2011;286:13966-76.
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40. KIRIS E , Ventimiglia D, Sargin ME, Gaylord MR, et al
    Combinatorial Tau pseudophosphorylation: markedly different regulatory effects on microtubule assembly and dynamic instability than the sum of the individual parts.
    J Biol Chem. 2011;286:14257-70.
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41. LASAGNA-REEVES CA , Glabe CG, Kayed R
    Amyloid-{beta} annular protofibrils evade fibrillar fate in Alzheimer's disease brain.
    J Biol Chem. 2011.
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42. LIU Y , Lee SY, Neely E, Nandar W, et al
    Mutant HFE H63D protein is associated with prolonged endoplasmic reticulum stress and increased neuronal vulnerability.
    J Biol Chem. 2011;286:13161-70.
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43. FINAN GM , Okada H, Kim TW
    BACE1 retrograde trafficking is uniquely regulated by the cytoplasmic domain of sortilin.
    J Biol Chem. 2011;286:12602-16.
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44. JIMENEZ S , Torres M, Vizuete M, Sanchez-Varo R, et al
    Age-dependent accumulation of soluble Abeta oligomers reverses the neuroprotective effect of sAPPalpha by modulating PI3K/Akt-GSK-3beta pathway in Alzheimer mice model.
    J Biol Chem. 2011.
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45. MATSUMURA S , Shinoda K, Yamada M, Yokojima S, et al
    Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analyses.
    J Biol Chem. 2011;286:11555-62.
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    March 2011
46. CACCAMO A , Maldonado MA, Majumder S, Medina DX, et al
    Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism.
    J Biol Chem. 2011;286:8924-32.
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47. GREENOUGH MA , Volitakis I, Li QX, Laughton K, et al
    Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity.
    J Biol Chem. 2011;286:9776-86.
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48. GENTILELLA A , Khalili K
    BAG3 expression in glioblastoma cells promotes accumulation of ubiquitinated clients in an Hsp70-dependent manner.
    J Biol Chem. 2011;286:9205-15.
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49. SUN X , Wu Y, Chen B, Zhang Z, et al
    Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation.
    J Biol Chem. 2011;286:9049-62.
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50. ZOU WQ , Xiao X, Yuan J, Puoti G, et al
    Amyloid beta interacts mainly with insoluble prion protein in the Alzheimer brain.
    J Biol Chem. 2011.
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51. ZHOU L , Chavez-Gutierrez L, Bockstael K, Sannerud R, et al
    Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.
    J Biol Chem. 2011;286:8677-87.
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52. KIM DY , Gersbacher MT, Inquimbert P, Kovacs DM, et al
    Reduced sodium channel Na(v)1.1 levels in BACE1-null mice.
    J Biol Chem. 2011;286:8106-16.
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53. ACEVEDO KM , Hung YH, Dalziel AH, Li QX, et al
    Copper promotes the trafficking of the amyloid precursor protein.
    J Biol Chem. 2011;286:8252-62.
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54. JAN A , Adolfsson O, Allaman I, Buccarello AL, et al
    Abeta42 neurotoxicity is mediated by ongoing nucleated polymerization process rather than by discrete Abeta42 species.
    J Biol Chem. 2011;286:8585-96.
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55. GUO JL , Lee VM
    Seeding of normal tau by pathological tau conformers drives pathogenesis of Alzheimer-like tangles.
    J Biol Chem. 2011.
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56. SHI J , Qian W, Yin X, Iqbal K, et al
    Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer's disease.
    J Biol Chem. 2011.
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    February 2011
57. NISHITSUJI K , Hosono T, Uchimura K, Michikawa M, et al
    Lipoprotein lipase is a novel amyloid beta (Abeta)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes.
    J Biol Chem. 2011;286:6393-401.
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58. HERSKOWITZ JH , Seyfried NT, Gearing M, Kahn RA, et al
    Rho kinase II phosphorylation of the lipoprotein receptor LR11/SORLA alters amyloid-beta production.
    J Biol Chem. 2011;286:6117-27.
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59. AMTUL Z , Uhrig M, Rozmahel RF, Beyreuther K, et al
    Structural insight into the differential effects of omega-3 and omega-6 fatty acids on the production of Abeta peptides and amyloid plaques.
    J Biol Chem. 2011;286:6100-7.
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60. JAWHAR S , Wirths O, Schilling S, Graubner S, et al
    Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in 5XFAD mice.
    J Biol Chem. 2011;286:4454-60.
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61. LIU B , Moloney A, Meehan S, Morris K, et al
    Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation.
    J Biol Chem. 2011;286:4248-56.
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62. SULTAN A , Nesslany F, Violet M, Begard S, et al
    Nuclear tau, a key player in neuronal DNA protection.
    J Biol Chem. 2011;286:4566-75.
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63. MAEZAWA I , Zimin PI, Wulff H, Jin LW, et al
    Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity.
    J Biol Chem. 2011;286:3693-706.
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    January 2011
64. DAMMER EB , Na CH, Xu P, Seyfried NT, et al
    Polyubiquitin linkage profiles in three models of proteolytic stress suggest etiology of Alzheimer disease.
    J Biol Chem. 2011.
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65. DELARASSE C , Auger R, Gonnord P, Fontaine B, et al
    The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein.
    J Biol Chem. 2011;286:2596-606.
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66. ZHANG C , Tanzi RE
    Response to mancuso et Al.: curcumin and Alzheimer disease: this marriage is not to be performed.
    J Biol Chem. 2011;286:le4.
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67. MANCUSO C , Siciliano R, Barone E
    Curcumin and Alzheimer disease: this marriage is not to be performed.
    J Biol Chem. 2011;286:le3.
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68. TSVETKOV P , Adamovich Y, Elliott E, Shaul Y, et al
    The E3 ligase STUB1/CHIP regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) accumulation in aged brain, a process impaired in certain Alzheimer patients.
    J Biol Chem. 2011.
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    December 2010
69. BELYAEV ND , Kellett KA, Beckett C, Makova NZ, et al
    The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway.
    J Biol Chem. 2010;285:41443-54.
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70. KOMATSU H , Feingold-Link E, Sharp KA, Rastogi T, et al
    Intrinsic linear heterogeneity of amyloid {beta} protein fibrils revealed by higher resolution mass-per-length determinations.
    J Biol Chem. 2010;285:41843-51.
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71. ANDO K , Uemura K, Kuzuya A, Maesako M, et al
    N-cadherin regulates p38MAPK signaling via association with JLP: Implications for neurodegeneration in Alzheimer's disease.
    J Biol Chem. 2010.
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72. KITAZUME S , Tachida Y, Kato M, Yamaguchi Y, et al
    Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form.
    J Biol Chem. 2010;285:40097-103.
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73. TAKATA K , Kitamura Y, Saeki M, Terada M, et al
    Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors.
    J Biol Chem. 2010;285:40180-91.
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74. HABIB LK , Lee MT, Yang J
    Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity.
    J Biol Chem. 2010;285:38933-43.
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75. NOONAN J , Tanveer R, Klompas A, Gowran A, et al
    Endocannabinoids prevent beta-amyloid-mediated lysosomal destabilization in cultured neurons.
    J Biol Chem. 2010;285:38543-54.
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76. KIMURA T , Fukuda T, Sahara N, Yamashita S, et al
    Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss.
    J Biol Chem. 2010;285:38692-9.
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    November 2010
77. CHEN HK , Ji ZS, Dodson SE, Miranda RD, et al
    Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer's disease.
    J Biol Chem. 2010.
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78. TAMBOLI IY , Barth E, Christian L, Siepmann M, et al
    Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion.
    J Biol Chem. 2010;285:37405-14.
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79. BOLAND B , Smith DA, Mooney D, Jung SS, et al
    Macroautophagy is not directly involved in the metabolism of amyloid precursor protein.
    J Biol Chem. 2010;285:37415-26.
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80. BOT N , Schweizer C, Ben Halima S, Fraering PC, et al
    Processing of the synaptic cell-adhesion molecule neurexin-3{beta} by Alzheimer's disease {alpha}- and {gamma}-secretases.
    J Biol Chem. 2010.
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    October 2010
81. SARELL CJ , Wilkinson SR, Viles JH
    Sub-stoichiometric levels of Copper2+ ions accelerate the kinetics of fibre formation and promote cell toxicity of amyloid-beta from Alzheimer's disease.
    J Biol Chem. 2010.
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82. WIRTHS O , Erck C, Martens H, Harmeier A, et al
    Identification of low molecular weight pyroglutamate abeta oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.
    J Biol Chem. 2010.
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83. LEROY A , Landrieu I, Huvent I, Legrand D, et al
    Spectroscopic studies of GSK3{beta} phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E.
    J Biol Chem. 2010;285:33435-44.
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84. TIAN Y , Crump CJ, Li YM
    Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production.
    J Biol Chem. 2010;285:32549-56.
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85. DIAZ-HERNANDEZ M , Gomez-Ramos A, Rubio A, Gomez-Villafuertes R, et al
    Tissue-nonspecific alkaline phosphatase promotes the neurotoxicity effect of extracellular tau.
    J Biol Chem. 2010;285:32539-48.
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86. CUI JG , Li YY, Zhao Y, Bhattacharjee S, et al
    Differential regulation of interleukin-1-receptor-associated kinase-1 (IRAK-1) and IRAK-2 by micro RNA-146a and NF-{kappa}B in stressed human astroglial cells and in Alzheimer's disease.
    J Biol Chem. 2010.
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87. SIDDIQUA A , Margittai M
    Three- and four-repeat tau coassemble into heterogeneous filaments: an implication for Alzheimer's disease.
    J Biol Chem. 2010.
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88. MINAGAWA H , Watanabe A, Akatsu H, Adachi K, et al
    Homocysteine, another risk factor for Alzheimer's disease, impairs apolipoprotein E3 function.
    J Biol Chem. 2010.
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89. LI H , Wang Z, Wang B, Guo Q, et al
    Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.
    J Biol Chem. 2010;285:30598-605.
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    September 2010
90. MA B , Nussinov R
    Polymorphic C-terminal {beta}-sheet interactions determine the formation of fibril or ADDL-like globulomer for the Alzheimer A{beta}42 dodecamer.
    J Biol Chem. 2010.
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91. LEWIS TL , Cao D, Lu H, Mans RA, et al
    Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer's disease.
    J Biol Chem. 2010.
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    August 2010
92. WEGMANN S , Jung YJ, Chinnathambi S, Mandelkow EM, et al
    Human Tau isoforms assemble into ribbon-like fibrils that display polymorphic structure and stability.
    J Biol Chem. 2010;285:27302-13.
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93. CHEN S , Yadav SP, Surewicz WK
    Interaction between human prion protein and amyloid-beta (Abeta) oligomers: role OF N-terminal residues.
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