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Alzheimer's Disease

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January 2012
1. OHTA H , Arai S, Akita K, Ohta T, et al
   Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease.
   PLoS One. 2012;7:e30007.
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2. BUIZZA L , Cenini G, Lanni C, Ferrari-Toninelli G, et al
   Conformational Altered p53 as an Early Marker of Oxidative Stress in Alzheimer's Disease.
   PLoS One. 2012;7:e29789.
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3. BJORKQVIST M , Ohlsson M, Minthon L, Hansson O, et al
   Evaluation of a previously suggested plasma biomarker panel to identify Alzheimer's disease.
   PLoS One. 2012;7:e29868.
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4. LEE HP , Pancholi N, Esposito L, Previll LA, et al
   Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity.
   PLoS One. 2012;7:e28033.
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5. CRUCHAGA C , Chakraverty S, Mayo K, Vallania FL, et al
   Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families.
   PLoS One. 2012;7:e31039.
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6. WESTIN K , Buchhave P, Nielsen H, Minthon L, et al
   CCL2 Is Associated with a Faster Rate of Cognitive Decline during Early Stages of Alzheimer's Disease.
   PLoS One. 2012;7:e30525.
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7. CZECH C , Berndt P, Busch K, Schmitz O, et al
   Metabolite profiling of Alzheimer's disease cerebrospinal fluid.
   PLoS One. 2012;7:e31501.
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8. KOIKKALAINEN J , Polonen H, Mattila J, van Gils M, et al
   Improved Classification of Alzheimer's Disease Data via Removal of Nuisance Variability.
   PLoS One. 2012;7:e31112.
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9. LEWIS V , Whitehouse IJ, Baybutt H, Manson JC, et al
   Cellular prion protein expression is not regulated by the Alzheimer's amyloid precursor protein intracellular domain.
   PLoS One. 2012;7:e31754.
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10. LIU T , Lipnicki DM, Zhu W, Tao D, et al
    Cortical gyrification and sulcal spans in early stage Alzheimer's disease.
    PLoS One. 2012;7:e31083.
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11. TRUSHINA E , Nemutlu E, Zhang S, Christensen T, et al
    Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease.
    PLoS One. 2012;7:e32737.
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12. PI R , Mao X, Chao X, Cheng Z, et al
    Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer, Inhibits Amyloid-beta-Mediated Alzheimer's Disease-Associated Pathogenesis In Vitro and In Vivo.
    PLoS One. 2012;7:e31921.
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13. CHUANG JY , Lee CW, Shih YH, Yang T, et al
    Interactions between Amyloid-beta and Hemoglobin: Implications for Amyloid Plaque Formation in Alzheimer's Disease.
    PLoS One. 2012;7:e33120.
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14. DEVI L , Alldred MJ, Ginsberg SD, Ohno M, et al
    Mechanisms Underlying Insulin Deficiency-Induced Acceleration of beta-Amyloidosis in a Mouse Model of Alzheimer's Disease.
    PLoS One. 2012;7:e32792.
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15. MATHEW A , Fukuda T, Nagaoka Y, Hasumura T, et al
    Curcumin Loaded-PLGA Nanoparticles Conjugated with Tet-1 Peptide for Potential Use in Alzheimer's Disease.
    PLoS One. 2012;7:e32616.
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16. JOZWIK A , Landowski J, Bidzan L, Fulop T, et al
    Beta-Amyloid Peptides Enhance the Proliferative Response of Activated CD4CD28 Lymphocytes from Alzheimer Disease Patients and from Healthy Elderly.
    PLoS One. 2012;7:e33276.
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17. MANOOK A , Yousefi BH, Willuweit A, Platzer S, et al
    Small-Animal PET Imaging of Amyloid-Beta Plaques with [C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer's Disease.
    PLoS One. 2012;7:e31310.
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18. ZHANG Q , Gao T, Luo Y, Chen X, et al
    Transient Focal Cerebral Ischemia/Reperfusion Induces Early and Chronic Axonal Changes in Rats: Its Importance for the Risk of Alzheimer's Disease.
    PLoS One. 2012;7:e33722.
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19. CRADDOCK TJ , Tuszynski JA, Chopra D, Casey N, et al
    The Zinc Dyshomeostasis Hypothesis of Alzheimer's Disease.
    PLoS One. 2012;7:e33552.
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20. ZHAO X , Liu Y, Wang X, Liu B, et al
    Disrupted Small-World Brain Networks in Moderate Alzheimer's Disease: A Resting-State fMRI Study.
    PLoS One. 2012;7:e33540.
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21. ZHANG C , Liu Y, Gilthorpe J, van der Maarel JR, et al
    MRP14 (S100A9) Protein Interacts with Alzheimer Beta-Amyloid Peptide and Induces Its Fibrillization.
    PLoS One. 2012;7:e32953.
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22. SVEDRUZIC ZM , Popovic K, Smoljan I, Sendula-Jengic V, et al
    Modulation of gamma-Secretase Activity by Multiple Enzyme-Substrate Interactions: Implications in Pathogenesis of Alzheimer's Disease.
    PLoS One. 2012;7:e32293.
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23. GRIMM MO , Zinser EG, Grosgen S, Hundsdorfer B, et al
    Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer's Disease Pathology with Ganglioside Metabolism.
    PLoS One. 2012;7:e34095.
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24. JUNG BK , Pyo KH, Shin KY, Hwang YS, et al
    Toxoplasma gondii Infection in the Brain Inhibits Neuronal Degeneration and Learning and Memory Impairments in a Murine Model of Alzheimer's Disease.
    PLoS One. 2012;7:e33312.
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25. JOHNSTONE D , Milward EA, Berretta R, Moscato P, et al
    Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset.
    PLoS One. 2012;7:e34341.
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26. MIYAZAWA K , Kipkorir T, Tittman S, Manuelidis L, et al
    Continuous production of prions after infectious particles are eliminated: implications for Alzheimer's disease.
    PLoS One. 2012;7:e35471.
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27. LING IF , Bhongsatiern J, Simpson JF, Fardo DW, et al
    Genetics of clusterin isoform expression and Alzheimer's disease risk.
    PLoS One. 2012;7:e33923.
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28. BIASUTTI M , Dufour N, Ferroud C, Dab W, et al
    Cost-effectiveness of magnetic resonance imaging with a new contrast agent for the early diagnosis of Alzheimer's disease.
    PLoS One. 2012;7:e35559.
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29. CACQUEVEL M , Aeschbach L, Houacine J, Fraering PC, et al
    Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified gamma-Secretase Complexes.
    PLoS One. 2012;7:e35133.
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30. ARENDASH GW , Mori T, Dorsey M, Gonzalez R, et al
    Electromagnetic Treatment to Old Alzheimer's Mice Reverses beta-Amyloid Deposition, Modifies Cerebral Blood Flow, and Provides Selected Cognitive Benefit.
    PLoS One. 2012;7:e35751.
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31. KE Y , Dramiga J, Schutz U, Kril JJ, et al
    Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease.
    PLoS One. 2012;7:e35678.
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32. PRETI MG , Baglio F, Lagana MM, Griffanti L, et al
    Assessing Corpus Callosum Changes in Alzheimer's Disease: Comparison between Tract-Based Spatial Statistics and Atlas-Based Tractography.
    PLoS One. 2012;7:e35856.
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33. FOX C , Crugel M, Maidment I, Auestad BH, et al
    Efficacy of memantine for agitation in Alzheimer's dementia: a randomised double-blind placebo controlled trial.
    PLoS One. 2012;7:e35185.
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    January 2011
34. ZHAO Y , Calon F, Julien C, Winkler JW, et al
    Docosahexaenoic Acid-Derived Neuroprotectin D1 Induces Neuronal Survival via Secretase- and PPARgamma-Mediated Mechanisms in Alzheimer's Disease Models.
    PLoS One. 2011;6:e15816.
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35. PERRIN RJ , Craig-Schapiro R, Malone JP, Shah AR, et al
    Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease.
    PLoS One. 2011;6:e16032.
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36. TWINE NA , Janitz K, Wilkins MR, Janitz M, et al
    Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease.
    PLoS One. 2011;6:e16266.
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37. FRYDMAN-MAROM A , Levin A, Farfara D, Benromano T, et al
    Orally Administrated Cinnamon Extract Reduces beta-Amyloid Oligomerization and Corrects Cognitive Impairment in Alzheimer's Disease Animal Models.
    PLoS One. 2011;6:e16564.
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38. SPENCER B , Marr RA, Gindi R, Potkar R, et al
    Peripheral delivery of a CNS targeted, metalo-protease reduces abeta toxicity in a mouse model of Alzheimer's disease.
    PLoS One. 2011;6:e16575.
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39. JONES PB , Adams KW, Rozkalne A, Spires-Jones TL, et al
    Apolipoprotein E: Isoform Specific Differences in Tertiary Structure and Interaction with Amyloid-beta in Human Alzheimer Brain.
    PLoS One. 2011;6:e14586.
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40. KAUWE JS , Cruchaga C, Karch CM, Sadler B, et al
    Fine Mapping of Genetic Variants in BIN1, CLU, CR1 and PICALM for Association with Cerebrospinal Fluid Biomarkers for Alzheimer's Disease.
    PLoS One. 2011;6:e15918.
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41. JONES L , Holmans PA, Hamshere ML, Harold D, et al
    Correction: genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.
    PLoS One. 2011;6.
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42. LUPTON MK , Proitsi P, Danillidou M, Tsolaki M, et al
    Deep sequencing of the nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.
    PLoS One. 2011;6:e17298.
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43. HU X , Pickering E, Liu YC, Hall S, et al
    Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease.
    PLoS One. 2011;6:e16616.
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44. OJHA J , Karmegam RV, Masilamoni JG, Terry AV, et al
    Behavioral defects in chaperone-deficient Alzheimer's disease model mice.
    PLoS One. 2011;6:e16550.
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45. ADLARD PA , Bica L, White AR, Nurjono M, et al
    Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease.
    PLoS One. 2011;6:e17669.
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46. ITKIN A , Dupres V, Dufrene YF, Bechinger B, et al
    Calcium Ions Promote Formation of Amyloid beta-Peptide (1-40) Oligomers Causally Implicated in Neuronal Toxicity of Alzheimer's Disease.
    PLoS One. 2011;6:e18250.
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47. KESSELS RP , van Doormaal A, Janzen G
    Landmark recognition in Alzheimer's dementia: spared implicit memory for objects relevant for navigation.
    PLoS One. 2011;6:e18611.
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48. CATTEPOEL S , Hanenberg M, Kulic L, Nitsch RM, et al
    Chronic Intranasal Treatment with an Anti-Abeta(30-42) scFv Antibody Ameliorates Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease.
    PLoS One. 2011;6:e18296.
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49. ROCHA DE PAULA M , Gomez Ravetti M, Berretta R, Moscato P, et al
    Differences in abundances of cell-signalling proteins in blood reveal novel biomarkers for early detection of clinical Alzheimer's disease.
    PLoS One. 2011;6:e17481.
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50. CRAIG-SCHAPIRO R , Kuhn M, Xiong C, Pickering EH, et al
    Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis.
    PLoS One. 2011;6:e18850.
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51. TRACTENBERG RE , Pietrzak RH
    Intra-individual variability in Alzheimer's disease and cognitive aging: definitions, context, and effect sizes.
    PLoS One. 2011;6:e16973.
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52. HOOGERHOUT P , Kamphuis W, Brugghe HF, Sluijs JA, et al
    A Cyclic Undecamer Peptide Mimics a Turn in Folded Alzheimer Amyloid beta and Elicits Antibodies against Oligomeric and Fibrillar Amyloid and Plaques.
    PLoS One. 2011;6:e19110.
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53. KOBAYASHI S , Tateno M, Park TW, Utsumi K, et al
    Apolipoprotein e4 frequencies in a Japanese population with Alzheimer's disease and dementia with lewy bodies.
    PLoS One. 2011;6:e18569.
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54. PHILLIPS M , Boman E, Osterman H, Willhite D, et al
    Olfactory and visuospatial learning and memory performance in two strains of Alzheimer's disease model mice-a longitudinal study.
    PLoS One. 2011;6:e19567.
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55. FROST D , Meechoovet B, Wang T, Gately S, et al
    beta-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites.
    PLoS One. 2011;6:e19264.
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56. BIGALKE B , Schreitmuller B, Sopova K, Paul A, et al
    Adipocytokines and CD34 Progenitor Cells in Alzheimer's Disease.
    PLoS One. 2011;6:e20286.
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57. LIN KP , Chen SY, Lai LC, Huang YL, et al
    Genetic Polymorphisms of a Novel Vascular Susceptibility Gene, Ninjurin2 (NINJ2), Are Associated with a Decreased Risk of Alzheimer's Disease.
    PLoS One. 2011;6:e20573.
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58. CHAKRABORTY R , Vepuri V, Mhatre SD, Paddock BE, et al
    Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects.
    PLoS One. 2011;6:e20799.
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59. BUTLER D , Hwang J, Estick C, Nishiyama A, et al
    Protective effects of positive lysosomal modulation in Alzheimer's disease transgenic mouse models.
    PLoS One. 2011;6:e20501.
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60. YU X , Zheng J
    Polymorphic Structures of Alzheimer's beta-Amyloid Globulomers.
    PLoS One. 2011;6:e20575.
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61. TAKEUCHI H , Mizoguchi H, Doi Y, Jin S, et al
    Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease.
    PLoS One. 2011;6:e21108.
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62. LANDRIEU I , Smet-Nocca C, Amniai L, Louis JV, et al
    Molecular Implication of PP2A and Pin1 in the Alzheimer's Disease Specific Hyperphosphorylation of Tau.
    PLoS One. 2011;6:e21521.
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63. CORONA C , Frazzini V, Silvestri E, Lattanzio R, et al
    Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.
    PLoS One. 2011;6:e17971.
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64. ARIKAWA M , Kakinuma Y, Handa T, Yamasaki F, et al
    Donepezil, Anti-Alzheimer's Disease Drug, Prevents Cardiac Rupture during Acute Phase of Myocardial Infarction in Mice.
    PLoS One. 2011;6:e20629.
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65. YAO J , Chen S, Mao Z, Cadenas E, et al
    2-deoxy-d-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease.
    PLoS One. 2011;6:e21788.
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66. O'DWYER L , Lamberton F, Bokde AL, Ewers M, et al
    Multiple indices of diffusion identifies white matter damage in mild cognitive impairment and Alzheimer's disease.
    PLoS One. 2011;6:e21745.
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67. CHADWICK W , Mitchell N, Caroll J, Zhou Y, et al
    Amitriptyline-mediated cognitive enhancement in aged 3xtg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity.
    PLoS One. 2011;6:e21660.
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68. KATSOURI L , Georgopoulos S
    Lack of LDL Receptor Enhances Amyloid Deposition and Decreases Glial Response in an Alzheimer's Disease Mouse Model.
    PLoS One. 2011;6:e21880.
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69. HAN X , Rozen S, Boyle SH, Hellegers C, et al
    Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics.
    PLoS One. 2011;6:e21643.
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70. PFEIFFER T , Bertram L, Ioannidis JP
    Quantifying selective reporting and the Proteus phenomenon for multiple datasets with similar bias.
    PLoS One. 2011;6:e18362.
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71. CUI Y , Liu B, Luo S, Zhen X, et al
    Identification of Conversion from Mild Cognitive Impairment to Alzheimer's Disease Using Multivariate Predictors.
    PLoS One. 2011;6:e21896.
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72. WESTMAN E , Cavallin L, Muehlboeck JS, Zhang Y, et al
    Sensitivity and Specificity of Medial Temporal Lobe Visual Ratings and Multivariate Regional MRI Classification in Alzheimer's Disease.
    PLoS One. 2011;6:e22506.
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73. PIETRZAK M , Rempala G, Nelson PT, Zheng JJ, et al
    Epigenetic Silencing of Nucleolar rRNA Genes in Alzheimer's Disease.
    PLoS One. 2011;6:e22585.
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74. WANG L , Yang H, Zhao S, Sato H, et al
    Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex.
    PLoS One. 2011;6:e22325.
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75. CALERO O , Bullido MJ, Clarimon J, Frank-Garcia A, et al
    Genetic Cross-Interaction between APOE and PRNP in Sporadic Alzheimer's and Creutzfeldt-Jakob Diseases.
    PLoS One. 2011;6:e22090.
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76. ZHU D , Shi J, Zhang Y, Wang B, et al
    Central angiotensin II stimulation promotes beta amyloid production in Sprague Dawley rats.
    PLoS One. 2011;6:e16037.
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77. NIIKURA T , Sidahmed E, Hirata-Fukae C, Aisen PS, et al
    A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice.
    PLoS One. 2011;6:e16259.
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78. PUCCIO S , Chu J, Pratico D
    Involvement of 5-lipoxygenase in the corticosteroid-dependent amyloid beta formation: in vitro and in vivo evidence.
    PLoS One. 2011;6:e15163.
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79. BORGE-HOLTHOEFER J , Moreno Y, Arenas A
    Modeling abnormal priming in Alzheimer's patients with a free association network.
    PLoS One. 2011;6:e22651.
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80. NAGELE E , Han M, Demarshall C, Belinka B, et al
    Diagnosis of Alzheimer's disease based on disease-specific autoantibody profiles in human sera.
    PLoS One. 2011;6:e23112.
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81. ARSENAULT D , Julien C, Tremblay C, Calon F, et al
    DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice.
    PLoS One. 2011;6:e17397.
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82. GILLIS J , Pavlidis P
    The impact of multifunctional genes on "guilt by association" analysis.
    PLoS One. 2011;6:e17258.
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83. CHEN S , Wang JM, Irwin RW, Yao J, et al
    Allopregnanolone Promotes Regeneration and Reduces beta-Amyloid Burden in a Preclinical Model of Alzheimer's Disease.
    PLoS One. 2011;6:e24293.
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84. BIRON KE , Dickstein DL, Gopaul R, Jefferies WA, et al
    Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease.
    PLoS One. 2011;6:e23789.
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85. ISRAELI E , Yakunin E, Zarbiv Y, Hacohen-Solovich A, et al
    alpha-Synuclein expression selectively affects tumorigenesis in mice modeling Parkinson's disease.
    PLoS One. 2011;6:e19622.
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86. BALSTERS JH , O'Connell RG, Martin MP, Galli A, et al
    Donepezil Impairs Memory in Healthy Older Subjects: Behavioural, EEG and Simultaneous EEG/fMRI Biomarkers.
    PLoS One. 2011;6:e24126.
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87. WEIDNER AM , Bradley MA, Beckett TL, Niedowicz DM, et al
    RNA Oxidation Adducts 8-OHG and 8-OHA Change with Abeta(42) Levels in Late-Stage Alzheimer's Disease.
    PLoS One. 2011;6:e24930.
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88. LULL ME , Levesque S, Surace MJ, Block ML, et al
    Chronic apocynin treatment attenuates beta amyloid plaque size and microglial number in hAPP(751)(SL) mice.
    PLoS One. 2011;6:e20153.
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89. REZAEI-GHALEH N , Andreetto E, Yan LM, Kapurniotu A, et al
    Interaction between amyloid beta peptide and an aggregation blocker peptide mimicking islet amyloid polypeptide.
    PLoS One. 2011;6:e20289.
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