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Articles published in Am J Pathol

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    February 2014
  1. MEDEIROS R, Castello NA, Cheng D, Kitazawa M, et al
    alpha7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
    Am J Pathol. 2014;184:520-9.
    PubMed     Text format     Related articles    Abstract available


    January 2014
  2. CHENG X, He P, Lee T, Yao H, et al
    High activities of BACE1 in brains with mild cognitive impairment.
    Am J Pathol. 2014;184:141-7.
    PubMed     Text format     Related articles    Abstract available


    July 2013
  3. YANG Y , Cudaback E, Jorstad NL, Hemingway JF, et al
    APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease.
    Am J Pathol. 2013 Jul 4. pii: S0002-9440(13)00395.
    PubMed     Text format     Related articles    Abstract available


    June 2013
  4. FROST JL , Le KX, Cynis H, Ekpo E, et al
    Pyroglutamate-3 Amyloid-beta Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease-Like Transgenic Mouse Models.
    Am J Pathol. 2013 Jun 6. pii: S0002-9440(13)00353.
    PubMed     Text format     Related articles    Abstract available


  5. ZOU K , Liu J, Watanabe A, Hiraga S, et al
    Abeta43 is the earliest-depositing Abeta species in APP transgenic mouse brain and is converted to Abeta41 by two active domains of ACE.
    Am J Pathol. 2013;182:2322-31.
    PubMed     Text format     Related articles    Abstract available


    April 2013
  6. SERRANO-POZO A , Gomez-Isla T, Growdon JH, Frosch MP, et al
    A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease.
    Am J Pathol. 2013 Apr 18. pii: S0002-9440(13)00210.
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  7. MONTGOMERY SL , Narrow WC, Mastrangelo MA, Olschowka JA, et al
    Chronic Neuron- and Age-Selective Down-Regulation of TNF Receptor Expression in Triple-Transgenic Alzheimer's Disease Mice Leads to Significant Modulation of Amyloid- and Tau-Related Pathologies.
    Am J Pathol. 2013 Apr 5. pii: S0002-9440(13)00209.
    PubMed     Text format     Related articles    Abstract available


    March 2013
  8. MEDEIROS R , Kitazawa M, Passos GF, Baglietto-Vargas D, et al
    Aspirin-Triggered Lipoxin A Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease-Like Pathology in Mice.
    Am J Pathol. 2013 Mar 15. pii: S0002-9440(13)00139.
    PubMed     Text format     Related articles    Abstract available


  9. UCHIDA Y , Gomi F, Murayama S, Takahashi H, et al
    Calsyntenin-3 C-Terminal Fragment Accumulates in Dystrophic Neurites Surrounding Abeta Plaques in Tg2576 Mouse and Alzheimer Disease Brains: Its Neurotoxic Role in Mediating Dystrophic Neurite Formation.
    Am J Pathol. 2013 Mar 12. pii: S0002-9440(13)00098.
    PubMed     Text format     Related articles    Abstract available


    December 2012
  10. WEGENAST-BRAUN BM , Skodras A, Bayraktar G, Mahler J, et al
    Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes.
    Am J Pathol. 2012;181:1953-60.
    PubMed     Text format     Related articles    Abstract available


    August 2012
  11. TAI HC , Serrano-Pozo A, Hashimoto T, Frosch MP, et al
    The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


    June 2012
  12. GETZ GS
    Calpain Inhibition as a Potential Treatment of Alzheimer's Disease.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


  13. MEDEIROS R , Kitazawa M, Chabrier M, Cheng D, et al
    Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease-Like Pathology and Cognitive Decline in Aged 3xTgAD Mice.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


    April 2012
  14. KOCH P , Tamboli IY, Mertens J, Wunderlich P, et al
    Presenilin-1 L166P Mutant Human Pluripotent Stem Cell-Derived Neurons Exhibit Partial Loss of gamma-Secretase Activity in Endogenous Amyloid-beta Generation.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


    March 2012
  15. MARCHESI VT
    Alzheimer's Disease 2012: The Great Amyloid Gamble.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


  16. HOSONO-FUKAO T , Ohtake-Niimi S, Hoshino H, Britschgi M, et al
    Heparan Sulfate Subdomains that are Degraded by Sulf Accumulate in Cerebral Amyloid ss Plaques of Alzheimer's Disease: Evidence from Mouse Models and Patients.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


    February 2012
  17. KIMURA N , Okabayashi S, Ono F
    Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function.
    Am J Pathol. 2012;180:550-61.
    PubMed     Text format     Related articles    Abstract available


    January 2012
  18. HOLLER CJ , Webb RL, Laux AL, Beckett TL, et al
    BACE2 expression increases in human neurodegenerative disease.
    Am J Pathol. 2012;180:337-50.
    PubMed     Text format     Related articles    Abstract available


    December 2011
  19. PEREZ SE , Getova DP, He B, Counts SE, et al
    Rac1b Increases with Progressive Tau Pathology within Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


    November 2011
  20. CAPETILLO-ZARATE E , Gracia L, Yu F, Banfelder JR, et al
    High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.
    Am J Pathol. 2011;179:2551-8.
    PubMed     Text format     Related articles    Abstract available


    October 2011
  21. KOPEIKINA KJ , Carlson GA, Pitstick R, Ludvigson AE, et al
    Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.
    Am J Pathol. 2011;179:2071-82.
    PubMed     Text format     Related articles    Abstract available


  22. MIZUNO T , Doi Y, Mizoguchi H, Jin S, et al
    Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-beta neurotoxicity.
    Am J Pathol. 2011;179:2016-27.
    PubMed     Text format     Related articles    Abstract available


    September 2011
  23. VOSS K , Koren J 3rd, Dickey CA
    The Earliest tau Dysfunction in Alzheimer's Disease? tau Phosphorylated at S422 as a Toxic Seed.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles   


  24. VANA L , Kanaan NM, Ugwu IC, Wuu J, et al
    Progression of Tau Pathology in Cholinergic Basal Forebrain Neurons in Mild Cognitive Impairment and Alzheimer's Disease.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


    August 2011
  25. MONTGOMERY SL , Mastrangelo MA, Habib D, Narrow WC, et al
    Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology Implications for Chronic Pan-TNF-alpha Suppressive Therapeutic Strategies in the Brain.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


    July 2011
  26. SERRANO-POZO A , Mielke ML, Gomez-Isla T, Betensky RA, et al
    Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


  27. LIM JE , Kou J, Song M, Pattanayak A, et al
    MyD88 Deficiency Ameliorates beta-Amyloidosis in an Animal Model of Alzheimer's Disease.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


    June 2011
  28. MEDEIROS R , Kitazawa M, Caccamo A, Baglietto-Vargas D, et al
    Loss of Muscarinic M(1) Receptor Exacerbates Alzheimer's Disease-Like Pathology and Cognitive Decline.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


  29. SY M , Kitazawa M, Medeiros R, Whitman L, et al
    Inflammation induced by infection potentiates tau pathological features in transgenic mice.
    Am J Pathol. 2011;178:2811-22.
    PubMed     Text format     Related articles    Abstract available


    May 2011
  30. LORD A , Philipson O, Klingstedt T, Westermark G, et al
    Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer's Disease.
    Am J Pathol. 2011;178:2286-98.
    PubMed     Text format     Related articles   


  31. REYES JF , Fu Y, Vana L, Kanaan NM, et al
    Tyrosine Nitration within the Proline-Rich Region of Tau in Alzheimer's Disease.
    Am J Pathol. 2011;178:2275-85.
    PubMed     Text format     Related articles   


    April 2011
  32. CHU J , Pratico D
    Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model Involvement of gamma-Secretase.
    Am J Pathol. 2011;178:1762-9.
    PubMed     Text format     Related articles    Abstract available


  33. WANG Y , Hancock AM, Bradner J, Chung KA, et al
    Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy.
    Am J Pathol. 2011;178:1509-16.
    PubMed     Text format     Related articles    Abstract available


  34. SOKOLOWSKI JD , Mandell JW
    Phagocytic clearance in neurodegeneration.
    Am J Pathol. 2011;178:1416-28.
    PubMed     Text format     Related articles    Abstract available


    January 2011
  35. HAFEZ D , Huang JY, Huynh AM, Valtierra S, et al
    Neprilysin-2 is an important beta-amyloid degrading enzyme.
    Am J Pathol. 2011;178:306-12.
    PubMed     Text format     Related articles    Abstract available


  36. JHAMANDAS JH , Li Z, Westaway D, Yang J, et al
    Actions of beta-amyloid protein on human neurons are expressed through the amylin receptor.
    Am J Pathol. 2011;178:140-9.
    PubMed     Text format     Related articles    Abstract available


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