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  Alzheimer's Disease

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Articles published in Am J Pathol

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    July 2013
  1. YANG Y , Cudaback E, Jorstad NL, Hemingway JF, et al
    APOE3, but Not APOE4, Bone Marrow Transplantation Mitigates Behavioral and Pathological Changes in a Mouse Model of Alzheimer Disease.
    Am J Pathol. 2013 Jul 4. pii: S0002-9440(13)00395.
    PubMed     Text format     Related articles    Abstract available


    June 2013
  2. FROST JL , Le KX, Cynis H, Ekpo E, et al
    Pyroglutamate-3 Amyloid-beta Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease-Like Transgenic Mouse Models.
    Am J Pathol. 2013 Jun 6. pii: S0002-9440(13)00353.
    PubMed     Text format     Related articles    Abstract available


  3. ZOU K , Liu J, Watanabe A, Hiraga S, et al
    Abeta43 is the earliest-depositing Abeta species in APP transgenic mouse brain and is converted to Abeta41 by two active domains of ACE.
    Am J Pathol. 2013;182:2322-31.
    PubMed     Text format     Related articles    Abstract available


    April 2013
  4. SERRANO-POZO A , Gomez-Isla T, Growdon JH, Frosch MP, et al
    A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease.
    Am J Pathol. 2013 Apr 18. pii: S0002-9440(13)00210.
    PubMed     Text format     Related articles    Abstract available


  5. MONTGOMERY SL , Narrow WC, Mastrangelo MA, Olschowka JA, et al
    Chronic Neuron- and Age-Selective Down-Regulation of TNF Receptor Expression in Triple-Transgenic Alzheimer's Disease Mice Leads to Significant Modulation of Amyloid- and Tau-Related Pathologies.
    Am J Pathol. 2013 Apr 5. pii: S0002-9440(13)00209.
    PubMed     Text format     Related articles    Abstract available


    March 2013
  6. MEDEIROS R , Kitazawa M, Passos GF, Baglietto-Vargas D, et al
    Aspirin-Triggered Lipoxin A Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease-Like Pathology in Mice.
    Am J Pathol. 2013 Mar 15. pii: S0002-9440(13)00139.
    PubMed     Text format     Related articles    Abstract available


  7. UCHIDA Y , Gomi F, Murayama S, Takahashi H, et al
    Calsyntenin-3 C-Terminal Fragment Accumulates in Dystrophic Neurites Surrounding Abeta Plaques in Tg2576 Mouse and Alzheimer Disease Brains: Its Neurotoxic Role in Mediating Dystrophic Neurite Formation.
    Am J Pathol. 2013 Mar 12. pii: S0002-9440(13)00098.
    PubMed     Text format     Related articles    Abstract available


    December 2012
  8. WEGENAST-BRAUN BM , Skodras A, Bayraktar G, Mahler J, et al
    Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes.
    Am J Pathol. 2012;181:1953-60.
    PubMed     Text format     Related articles    Abstract available


    August 2012
  9. TAI HC , Serrano-Pozo A, Hashimoto T, Frosch MP, et al
    The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


    June 2012
  10. GETZ GS
    Calpain Inhibition as a Potential Treatment of Alzheimer's Disease.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


  11. MEDEIROS R , Kitazawa M, Chabrier M, Cheng D, et al
    Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease-Like Pathology and Cognitive Decline in Aged 3xTgAD Mice.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


    April 2012
  12. KOCH P , Tamboli IY, Mertens J, Wunderlich P, et al
    Presenilin-1 L166P Mutant Human Pluripotent Stem Cell-Derived Neurons Exhibit Partial Loss of gamma-Secretase Activity in Endogenous Amyloid-beta Generation.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


    March 2012
  13. MARCHESI VT
    Alzheimer's Disease 2012: The Great Amyloid Gamble.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


  14. HOSONO-FUKAO T , Ohtake-Niimi S, Hoshino H, Britschgi M, et al
    Heparan Sulfate Subdomains that are Degraded by Sulf Accumulate in Cerebral Amyloid ss Plaques of Alzheimer's Disease: Evidence from Mouse Models and Patients.
    Am J Pathol. 2012.
    PubMed     Text format     Related articles    Abstract available


    February 2012
  15. KIMURA N , Okabayashi S, Ono F
    Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function.
    Am J Pathol. 2012;180:550-61.
    PubMed     Text format     Related articles    Abstract available


    January 2012
  16. HOLLER CJ , Webb RL, Laux AL, Beckett TL, et al
    BACE2 expression increases in human neurodegenerative disease.
    Am J Pathol. 2012;180:337-50.
    PubMed     Text format     Related articles    Abstract available


    December 2011
  17. PEREZ SE , Getova DP, He B, Counts SE, et al
    Rac1b Increases with Progressive Tau Pathology within Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


    November 2011
  18. CAPETILLO-ZARATE E , Gracia L, Yu F, Banfelder JR, et al
    High-resolution 3D reconstruction reveals intra-synaptic amyloid fibrils.
    Am J Pathol. 2011;179:2551-8.
    PubMed     Text format     Related articles    Abstract available


    October 2011
  19. KOPEIKINA KJ , Carlson GA, Pitstick R, Ludvigson AE, et al
    Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.
    Am J Pathol. 2011;179:2071-82.
    PubMed     Text format     Related articles    Abstract available


  20. MIZUNO T , Doi Y, Mizoguchi H, Jin S, et al
    Interleukin-34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-beta neurotoxicity.
    Am J Pathol. 2011;179:2016-27.
    PubMed     Text format     Related articles    Abstract available


    September 2011
  21. VOSS K , Koren J 3rd, Dickey CA
    The Earliest tau Dysfunction in Alzheimer's Disease? tau Phosphorylated at S422 as a Toxic Seed.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles   


  22. VANA L , Kanaan NM, Ugwu IC, Wuu J, et al
    Progression of Tau Pathology in Cholinergic Basal Forebrain Neurons in Mild Cognitive Impairment and Alzheimer's Disease.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


    August 2011
  23. MONTGOMERY SL , Mastrangelo MA, Habib D, Narrow WC, et al
    Ablation of TNF-RI/RII Expression in Alzheimer's Disease Mice Leads to an Unexpected Enhancement of Pathology Implications for Chronic Pan-TNF-alpha Suppressive Therapeutic Strategies in the Brain.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


    July 2011
  24. SERRANO-POZO A , Mielke ML, Gomez-Isla T, Betensky RA, et al
    Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


  25. LIM JE , Kou J, Song M, Pattanayak A, et al
    MyD88 Deficiency Ameliorates beta-Amyloidosis in an Animal Model of Alzheimer's Disease.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


    June 2011
  26. MEDEIROS R , Kitazawa M, Caccamo A, Baglietto-Vargas D, et al
    Loss of Muscarinic M(1) Receptor Exacerbates Alzheimer's Disease-Like Pathology and Cognitive Decline.
    Am J Pathol. 2011.
    PubMed     Text format     Related articles    Abstract available


  27. SY M , Kitazawa M, Medeiros R, Whitman L, et al
    Inflammation induced by infection potentiates tau pathological features in transgenic mice.
    Am J Pathol. 2011;178:2811-22.
    PubMed     Text format     Related articles    Abstract available


    May 2011
  28. LORD A , Philipson O, Klingstedt T, Westermark G, et al
    Observations in APP Bitransgenic Mice Suggest that Diffuse and Compact Plaques Form via Independent Processes in Alzheimer's Disease.
    Am J Pathol. 2011;178:2286-98.
    PubMed     Text format     Related articles   


  29. REYES JF , Fu Y, Vana L, Kanaan NM, et al
    Tyrosine Nitration within the Proline-Rich Region of Tau in Alzheimer's Disease.
    Am J Pathol. 2011;178:2275-85.
    PubMed     Text format     Related articles   


    April 2011
  30. CHU J , Pratico D
    Pharmacologic Blockade of 5-Lipoxygenase Improves the Amyloidotic Phenotype of an Alzheimer's Disease Transgenic Mouse Model Involvement of gamma-Secretase.
    Am J Pathol. 2011;178:1762-9.
    PubMed     Text format     Related articles    Abstract available


  31. WANG Y , Hancock AM, Bradner J, Chung KA, et al
    Complement 3 and factor h in human cerebrospinal fluid in Parkinson's disease, Alzheimer's disease, and multiple-system atrophy.
    Am J Pathol. 2011;178:1509-16.
    PubMed     Text format     Related articles    Abstract available


  32. SOKOLOWSKI JD , Mandell JW
    Phagocytic clearance in neurodegeneration.
    Am J Pathol. 2011;178:1416-28.
    PubMed     Text format     Related articles    Abstract available


    January 2011
  33. HAFEZ D , Huang JY, Huynh AM, Valtierra S, et al
    Neprilysin-2 is an important beta-amyloid degrading enzyme.
    Am J Pathol. 2011;178:306-12.
    PubMed     Text format     Related articles    Abstract available


  34. JHAMANDAS JH , Li Z, Westaway D, Yang J, et al
    Actions of beta-amyloid protein on human neurons are expressed through the amylin receptor.
    Am J Pathol. 2011;178:140-9.
    PubMed     Text format     Related articles    Abstract available


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